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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus coagulans 36D1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

Cofactori

thiamine diphosphateUniRule annotationSAAS annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-HAMAP
  2. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBCOA345219:GH5A-3214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotationSAAS annotation (EC:1.2.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
ORF Names:Bcoa_3252Imported
OrganismiBacillus coagulans 36D1Imported
Taxonomic identifieri345219 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000009283 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliG2TMC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

G2TMC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATTPKGFW ESFSGPNLGY VMDLYEQYLE DPESIDEEAR KVFDQWGAPA
60 70 80 90 100
VSEGGSPTQG QADISFQLPA NPTIFSKMVA AVKLADNIRT FGHLAADINP
110 120 130 140 150
LQKPVGDVRR IELGEFDLTE EDLKKVPASF ICPDAPKRVK NGLDAINYLK
160 170 180 190 200
EVYTQKVAFE FDHIHDMEEK HWLQRTVESG SFFRELSRKQ KIGILKRLSD
210 220 230 240 250
VEGFEKFIHR TFVGQKRFSI EGLDALVPLM EQMIIEAVKT GVKTVNIGMA
260 270 280 290 300
HRGRLNVLAH ILEKPYELIF AEFKHASNKD LIPSEGSIGI TYGWTGDVKY
310 320 330 340 350
HLGADRKGQN GGPIGARIVL ANNPSHLEVA DPVVEGYTRA AQDNRNKTGY
360 370 380 390 400
PDRDPDRAFA ILVHGDAAFA GQGIVAETLN MSKLNGYGTG GTIHIIANNN
410 420 430 440 450
IGFTTETYDS RSTKYASDPA KGYEVPILHV NADDPEACVQ AALFAYAYRE
460 470 480 490 500
KFHKDFVIDL VGYRRYGHNE MDEPMVTNPV MYHAVHNHPT VRAIYGEQLA
510 520 530 540 550
KEGVLTAEEV KTIDEAVQKK LQAAYEKVPD GEAEPDTAME PPENVKKGYL
560 570 580 590 600
SMETGVPEQE LRAWNAELLA WPENFHVFKK LARILKRREH VFDGKGKIDW
610 620 630 640 650
AHAEALAFAA ILKDGVPIRF TGQDTQRGTF AQRNLVLHDE QTGEEYIPHH
660 670 680 690 700
HLSGVQTSFA IYNSPLTEAG VVGFEYGYNV FSPDTLVIWE AQFGDFANMA
710 720 730 740 750
QVMFDQFISS GRAKWGQKSG LVMMLPHGYE GQGPEHSSGR VERFLQLAAE
760 770 780 790 800
NNWTVANVST AGQYFHILRR QAKWLAKEEI RPLVLMTPKS LLRHPLASVE
810 820 830 840 850
PSVLTDGKFH TVLEGPGTKN TDAVERILLC SGKVAVDLEE KLNSAENTSW
860 870 880 890 900
LHTVRVEQIY PFPEQELKEI FARFKNAKEI VWMQEEPKNM GSWSFVEPYL
910 920 930 940
RKLAPQGAEI RYIGRPRRSS PSEGDPVVHK KEQNRILTEA ITRP
Length:944
Mass (Da):105,898
Last modified:November 16, 2011 - v1
Checksum:i90B02AFEB134490C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003056 Genomic DNA. Translation: AEP02424.1.
RefSeqiYP_004861204.1. NC_016023.1.

Genome annotation databases

EnsemblBacteriaiAEP02424; AEP02424; Bcoa_3252.
KEGGibag:Bcoa_3252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003056 Genomic DNA. Translation: AEP02424.1.
RefSeqiYP_004861204.1. NC_016023.1.

3D structure databases

ProteinModelPortaliG2TMC6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEP02424; AEP02424; Bcoa_3252.
KEGGibag:Bcoa_3252.

Phylogenomic databases

KOiK00164.

Enzyme and pathway databases

BioCyciBCOA345219:GH5A-3214-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 36D1Imported.

Entry informationi

Entry nameiG2TMC6_BACCO
AccessioniPrimary (citable) accession number: G2TMC6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 1, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.