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G2TMC6

- G2TMC6_BACCO

UniProt

G2TMC6 - G2TMC6_BACCO

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, Bcoa_3252
Organism
Bacillus coagulans 36D1
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotations

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotations

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBCOA345219:GH5A-3214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhAUniRule annotation
ORF Names:Bcoa_3252Imported
OrganismiBacillus coagulans 36D1Imported
Taxonomic identifieri345219 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000009283: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliG2TMC6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

G2TMC6-1 [UniParc]FASTAAdd to Basket

« Hide

MNATTPKGFW ESFSGPNLGY VMDLYEQYLE DPESIDEEAR KVFDQWGAPA    50
VSEGGSPTQG QADISFQLPA NPTIFSKMVA AVKLADNIRT FGHLAADINP 100
LQKPVGDVRR IELGEFDLTE EDLKKVPASF ICPDAPKRVK NGLDAINYLK 150
EVYTQKVAFE FDHIHDMEEK HWLQRTVESG SFFRELSRKQ KIGILKRLSD 200
VEGFEKFIHR TFVGQKRFSI EGLDALVPLM EQMIIEAVKT GVKTVNIGMA 250
HRGRLNVLAH ILEKPYELIF AEFKHASNKD LIPSEGSIGI TYGWTGDVKY 300
HLGADRKGQN GGPIGARIVL ANNPSHLEVA DPVVEGYTRA AQDNRNKTGY 350
PDRDPDRAFA ILVHGDAAFA GQGIVAETLN MSKLNGYGTG GTIHIIANNN 400
IGFTTETYDS RSTKYASDPA KGYEVPILHV NADDPEACVQ AALFAYAYRE 450
KFHKDFVIDL VGYRRYGHNE MDEPMVTNPV MYHAVHNHPT VRAIYGEQLA 500
KEGVLTAEEV KTIDEAVQKK LQAAYEKVPD GEAEPDTAME PPENVKKGYL 550
SMETGVPEQE LRAWNAELLA WPENFHVFKK LARILKRREH VFDGKGKIDW 600
AHAEALAFAA ILKDGVPIRF TGQDTQRGTF AQRNLVLHDE QTGEEYIPHH 650
HLSGVQTSFA IYNSPLTEAG VVGFEYGYNV FSPDTLVIWE AQFGDFANMA 700
QVMFDQFISS GRAKWGQKSG LVMMLPHGYE GQGPEHSSGR VERFLQLAAE 750
NNWTVANVST AGQYFHILRR QAKWLAKEEI RPLVLMTPKS LLRHPLASVE 800
PSVLTDGKFH TVLEGPGTKN TDAVERILLC SGKVAVDLEE KLNSAENTSW 850
LHTVRVEQIY PFPEQELKEI FARFKNAKEI VWMQEEPKNM GSWSFVEPYL 900
RKLAPQGAEI RYIGRPRRSS PSEGDPVVHK KEQNRILTEA ITRP 944
Length:944
Mass (Da):105,898
Last modified:November 16, 2011 - v1
Checksum:i90B02AFEB134490C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003056 Genomic DNA. Translation: AEP02424.1.
RefSeqiYP_004861204.1. NC_016023.1.

Genome annotation databases

EnsemblBacteriaiAEP02424; AEP02424; Bcoa_3252.
GeneIDi11174178.
KEGGibag:Bcoa_3252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003056 Genomic DNA. Translation: AEP02424.1 .
RefSeqi YP_004861204.1. NC_016023.1.

3D structure databases

ProteinModelPortali G2TMC6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEP02424 ; AEP02424 ; Bcoa_3252 .
GeneIDi 11174178.
KEGGi bag:Bcoa_3252.

Phylogenomic databases

KOi K00164.

Enzyme and pathway databases

BioCyci BCOA345219:GH5A-3214-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 36D1Imported.

Entry informationi

Entry nameiG2TMC6_BACCO
AccessioniPrimary (citable) accession number: G2TMC6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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