G2TMC6 (G2TMC6_BACCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
EC=1.2.4.2 HAMAP-Rule MF_01169

Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169

Gene names

Name:	odhA HAMAP-Rule MF_01169
ORF Names:	Bcoa_3252 EMBL AEP02424.1

Organism

Bacillus coagulans 36D1 EMBL AEP02424.1

Taxonomic identifier

345219 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus coagulans

Protein attributes

Sequence length	944 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169 SAAS SAAS001017
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169 SAAS SAAS001017
Cofactor	Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01169 SAAS SAAS001017
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS001017 HAMAP-Rule MF_01169
Ligand	Thiamine pyrophosphate HAMAP-Rule MF_01169 SAAS SAAS023784
Molecular function	Oxidoreductase HAMAP-Rule MF_01169 SAAS SAAS023784
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamine pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G2TMC6 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: 90B02AFEB134490C	FASTA	944	105,898
	10 20 30 40 50 60 MNATTPKGFW ESFSGPNLGY VMDLYEQYLE DPESIDEEAR KVFDQWGAPA VSEGGSPTQG 70 80 90 100 110 120 QADISFQLPA NPTIFSKMVA AVKLADNIRT FGHLAADINP LQKPVGDVRR IELGEFDLTE 130 140 150 160 170 180 EDLKKVPASF ICPDAPKRVK NGLDAINYLK EVYTQKVAFE FDHIHDMEEK HWLQRTVESG 190 200 210 220 230 240 SFFRELSRKQ KIGILKRLSD VEGFEKFIHR TFVGQKRFSI EGLDALVPLM EQMIIEAVKT 250 260 270 280 290 300 GVKTVNIGMA HRGRLNVLAH ILEKPYELIF AEFKHASNKD LIPSEGSIGI TYGWTGDVKY 310 320 330 340 350 360 HLGADRKGQN GGPIGARIVL ANNPSHLEVA DPVVEGYTRA AQDNRNKTGY PDRDPDRAFA 370 380 390 400 410 420 ILVHGDAAFA GQGIVAETLN MSKLNGYGTG GTIHIIANNN IGFTTETYDS RSTKYASDPA 430 440 450 460 470 480 KGYEVPILHV NADDPEACVQ AALFAYAYRE KFHKDFVIDL VGYRRYGHNE MDEPMVTNPV 490 500 510 520 530 540 MYHAVHNHPT VRAIYGEQLA KEGVLTAEEV KTIDEAVQKK LQAAYEKVPD GEAEPDTAME 550 560 570 580 590 600 PPENVKKGYL SMETGVPEQE LRAWNAELLA WPENFHVFKK LARILKRREH VFDGKGKIDW 610 620 630 640 650 660 AHAEALAFAA ILKDGVPIRF TGQDTQRGTF AQRNLVLHDE QTGEEYIPHH HLSGVQTSFA 670 680 690 700 710 720 IYNSPLTEAG VVGFEYGYNV FSPDTLVIWE AQFGDFANMA QVMFDQFISS GRAKWGQKSG 730 740 750 760 770 780 LVMMLPHGYE GQGPEHSSGR VERFLQLAAE NNWTVANVST AGQYFHILRR QAKWLAKEEI 790 800 810 820 830 840 RPLVLMTPKS LLRHPLASVE PSVLTDGKFH TVLEGPGTKN TDAVERILLC SGKVAVDLEE 850 860 870 880 890 900 KLNSAENTSW LHTVRVEQIY PFPEQELKEI FARFKNAKEI VWMQEEPKNM GSWSFVEPYL 910 920 930 940 RKLAPQGAEI RYIGRPRRSS PSEGDPVVHK KEQNRILTEA ITRP

References

[1]	US DOE Joint Genome Institute (JGI-PGF) Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Chertkov O., Brettin T., Han C., Detter C., Pitluck S., Shanmugam K.T. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 36D1 EMBL AEP02424.1.
[2]	"Complete Genome Sequence of a thermotolerant sporogenic lactic acid bacterium, Bacillus coagulans strain 36D1." Rhee M.S., Moritz B.E., Xie G., Glavina Del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Chertkov O., Brettin T., Han C., Detter C., Pitluck S., Land M.L., Patel M., Ou M., Harbrucker R., Ingram L.O., Shanmugam K.T. Stand. Genomic Sci. 5:331-340(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 36D1 EMBL AEP02424.1.
[3]	Shanmugan K.T. Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 36D1 EMBL AEP02424.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003056 Genomic DNA. Translation: AEP02424.1.
RefSeq	YP_004861204.1. NC_016023.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEP02424; AEP02424; Bcoa_3252.
GeneID	11174178.
KEGG	bag:Bcoa_3252.
Phylogenomic databases
KO	K00164.
Enzyme and pathway databases
BioCyc	BCOA345219:GH5A-3214-MONOMER.
Family and domain databases
HAMAP	MF_01169. SucA_OdhA.
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR023784. 2oxoglutarate_DH_E1_bac. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G2TMC6_BACCO

Accession

Primary (citable) accession number: G2TMC6

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	May 29, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)