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G2TMC6 (G2TMC6_BACCO) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169

EC=1.2.4.2 HAMAP-Rule MF_01169
Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169
Gene names
Name:odhA HAMAP-Rule MF_01169
ORF Names:Bcoa_3252 EMBL AEP02424.1
OrganismBacillus coagulans 36D1 [Complete proteome] EMBL AEP02424.1
Taxonomic identifier345219 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169 SAAS SAAS023784

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Subunit structure

Homodimer By similarity. SAAS SAAS023784 HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Sequences

Sequence LengthMass (Da)Tools
G2TMC6 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 90B02AFEB134490C

FASTA944105,898
        10         20         30         40         50         60 
MNATTPKGFW ESFSGPNLGY VMDLYEQYLE DPESIDEEAR KVFDQWGAPA VSEGGSPTQG 

        70         80         90        100        110        120 
QADISFQLPA NPTIFSKMVA AVKLADNIRT FGHLAADINP LQKPVGDVRR IELGEFDLTE 

       130        140        150        160        170        180 
EDLKKVPASF ICPDAPKRVK NGLDAINYLK EVYTQKVAFE FDHIHDMEEK HWLQRTVESG 

       190        200        210        220        230        240 
SFFRELSRKQ KIGILKRLSD VEGFEKFIHR TFVGQKRFSI EGLDALVPLM EQMIIEAVKT 

       250        260        270        280        290        300 
GVKTVNIGMA HRGRLNVLAH ILEKPYELIF AEFKHASNKD LIPSEGSIGI TYGWTGDVKY 

       310        320        330        340        350        360 
HLGADRKGQN GGPIGARIVL ANNPSHLEVA DPVVEGYTRA AQDNRNKTGY PDRDPDRAFA 

       370        380        390        400        410        420 
ILVHGDAAFA GQGIVAETLN MSKLNGYGTG GTIHIIANNN IGFTTETYDS RSTKYASDPA 

       430        440        450        460        470        480 
KGYEVPILHV NADDPEACVQ AALFAYAYRE KFHKDFVIDL VGYRRYGHNE MDEPMVTNPV 

       490        500        510        520        530        540 
MYHAVHNHPT VRAIYGEQLA KEGVLTAEEV KTIDEAVQKK LQAAYEKVPD GEAEPDTAME 

       550        560        570        580        590        600 
PPENVKKGYL SMETGVPEQE LRAWNAELLA WPENFHVFKK LARILKRREH VFDGKGKIDW 

       610        620        630        640        650        660 
AHAEALAFAA ILKDGVPIRF TGQDTQRGTF AQRNLVLHDE QTGEEYIPHH HLSGVQTSFA 

       670        680        690        700        710        720 
IYNSPLTEAG VVGFEYGYNV FSPDTLVIWE AQFGDFANMA QVMFDQFISS GRAKWGQKSG 

       730        740        750        760        770        780 
LVMMLPHGYE GQGPEHSSGR VERFLQLAAE NNWTVANVST AGQYFHILRR QAKWLAKEEI 

       790        800        810        820        830        840 
RPLVLMTPKS LLRHPLASVE PSVLTDGKFH TVLEGPGTKN TDAVERILLC SGKVAVDLEE 

       850        860        870        880        890        900 
KLNSAENTSW LHTVRVEQIY PFPEQELKEI FARFKNAKEI VWMQEEPKNM GSWSFVEPYL 

       910        920        930        940 
RKLAPQGAEI RYIGRPRRSS PSEGDPVVHK KEQNRILTEA ITRP 

« Hide

References

[1]US DOE Joint Genome Institute (JGI-PGF)
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Chertkov O., Brettin T., Han C., Detter C., Pitluck S., Shanmugam K.T.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 36D1 EMBL AEP02424.1.
[2]"Complete Genome Sequence of a thermotolerant sporogenic lactic acid bacterium, Bacillus coagulans strain 36D1."
Rhee M.S., Moritz B.E., Xie G., Glavina Del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Chertkov O., Brettin T., Han C., Detter C., Pitluck S., Land M.L., Patel M., Ou M., Harbrucker R., Ingram L.O., Shanmugam K.T.
Stand. Genomic Sci. 5:331-340(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 36D1 EMBL AEP02424.1.
[3]Shanmugan K.T.
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 36D1 EMBL AEP02424.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003056 Genomic DNA. Translation: AEP02424.1.
RefSeqYP_004861204.1. NC_016023.1.

3D structure databases

ProteinModelPortalG2TMC6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEP02424; AEP02424; Bcoa_3252.
GeneID11174178.
KEGGbag:Bcoa_3252.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00164.

Enzyme and pathway databases

BioCycBCOA345219:GH5A-3214-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG2TMC6_BACCO
AccessionPrimary (citable) accession number: G2TMC6
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)