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G2TMC6

- G2TMC6_BACCO

UniProt

G2TMC6 - G2TMC6_BACCO

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus coagulans 36D1
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBCOA345219:GH5A-3214-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:odhAUniRule annotation
    ORF Names:Bcoa_3252Imported
    OrganismiBacillus coagulans 36D1Imported
    Taxonomic identifieri345219 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000009283: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG2TMC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    KOiK00164.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G2TMC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNATTPKGFW ESFSGPNLGY VMDLYEQYLE DPESIDEEAR KVFDQWGAPA    50
    VSEGGSPTQG QADISFQLPA NPTIFSKMVA AVKLADNIRT FGHLAADINP 100
    LQKPVGDVRR IELGEFDLTE EDLKKVPASF ICPDAPKRVK NGLDAINYLK 150
    EVYTQKVAFE FDHIHDMEEK HWLQRTVESG SFFRELSRKQ KIGILKRLSD 200
    VEGFEKFIHR TFVGQKRFSI EGLDALVPLM EQMIIEAVKT GVKTVNIGMA 250
    HRGRLNVLAH ILEKPYELIF AEFKHASNKD LIPSEGSIGI TYGWTGDVKY 300
    HLGADRKGQN GGPIGARIVL ANNPSHLEVA DPVVEGYTRA AQDNRNKTGY 350
    PDRDPDRAFA ILVHGDAAFA GQGIVAETLN MSKLNGYGTG GTIHIIANNN 400
    IGFTTETYDS RSTKYASDPA KGYEVPILHV NADDPEACVQ AALFAYAYRE 450
    KFHKDFVIDL VGYRRYGHNE MDEPMVTNPV MYHAVHNHPT VRAIYGEQLA 500
    KEGVLTAEEV KTIDEAVQKK LQAAYEKVPD GEAEPDTAME PPENVKKGYL 550
    SMETGVPEQE LRAWNAELLA WPENFHVFKK LARILKRREH VFDGKGKIDW 600
    AHAEALAFAA ILKDGVPIRF TGQDTQRGTF AQRNLVLHDE QTGEEYIPHH 650
    HLSGVQTSFA IYNSPLTEAG VVGFEYGYNV FSPDTLVIWE AQFGDFANMA 700
    QVMFDQFISS GRAKWGQKSG LVMMLPHGYE GQGPEHSSGR VERFLQLAAE 750
    NNWTVANVST AGQYFHILRR QAKWLAKEEI RPLVLMTPKS LLRHPLASVE 800
    PSVLTDGKFH TVLEGPGTKN TDAVERILLC SGKVAVDLEE KLNSAENTSW 850
    LHTVRVEQIY PFPEQELKEI FARFKNAKEI VWMQEEPKNM GSWSFVEPYL 900
    RKLAPQGAEI RYIGRPRRSS PSEGDPVVHK KEQNRILTEA ITRP 944
    Length:944
    Mass (Da):105,898
    Last modified:November 16, 2011 - v1
    Checksum:i90B02AFEB134490C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003056 Genomic DNA. Translation: AEP02424.1.
    RefSeqiYP_004861204.1. NC_016023.1.

    Genome annotation databases

    EnsemblBacteriaiAEP02424; AEP02424; Bcoa_3252.
    GeneIDi11174178.
    KEGGibag:Bcoa_3252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003056 Genomic DNA. Translation: AEP02424.1 .
    RefSeqi YP_004861204.1. NC_016023.1.

    3D structure databases

    ProteinModelPortali G2TMC6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEP02424 ; AEP02424 ; Bcoa_3252 .
    GeneIDi 11174178.
    KEGGi bag:Bcoa_3252.

    Phylogenomic databases

    KOi K00164.

    Enzyme and pathway databases

    BioCyci BCOA345219:GH5A-3214-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 36D1Imported.

    Entry informationi

    Entry nameiG2TMC6_BACCO
    AccessioniPrimary (citable) accession number: G2TMC6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3