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G2TIL8 (G2TIL8_BACCO) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase RuleBase RU004247 HAMAP-Rule MF_01201

EC=5.1.1.1 RuleBase RU004247 HAMAP-Rule MF_01201
Gene names
ORF Names:Bcoa_1503 EMBL AEP00709.1
OrganismBacillus coagulans 36D1 [Complete proteome] EMBL AEP00709.1
Taxonomic identifier345219 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. RuleBase RU004247 HAMAP-Rule MF_01201 SAAS SAAS009006

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site381Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2631Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1341Substrate By similarity HAMAP-Rule MF_01201
Binding site3101Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue381N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
G2TIL8 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 7AFDE10989530FFB

FASTA38341,931
        10         20         30         40         50         60 
MAFYRDTWVE VDLDAISENV GNMRQLLPEH TQIIAVVKAN AYGHGAEYVA KTALASGASA 

        70         80         90        100        110        120 
LAVAFLDEAL ALRKKGITAP ILVLGAARPE DAGVAAEENI SLTVFQKDWL EEAGRYLTGR 

       130        140        150        160        170        180 
KLSVHLKCDT GMGRIGVRTL QELKEVEKIV NQQSCFYFEG IFTHFATADE IDTTLYEKQY 

       190        200        210        220        230        240 
SQFQDMVLNL EHRPPYVHCA NSAAALRFDQ SPFNAVRFGI AMYGLSPSPA IKPVLPFPLK 

       250        260        270        280        290        300 
EAFSLHTKVT HVKQIHAGDT VSYGATYQAS GDEWIATLPI GYADGWIRRL SGQEVIIDGE 

       310        320        330        340        350        360 
RAPIVGRICM DQCMVKLARP VAVGTKATLI GKQGDLSIPV DEIAEKLETI NYEVTCSISS 

       370        380 
RVPRIFLKNG NDVADVSNPV LEG 

« Hide

References

[1]US DOE Joint Genome Institute (JGI-PGF)
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Chertkov O., Brettin T., Han C., Detter C., Pitluck S., Shanmugam K.T.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 36D1 EMBL AEP00709.1.
[2]"Complete Genome Sequence of a thermotolerant sporogenic lactic acid bacterium, Bacillus coagulans strain 36D1."
Rhee M.S., Moritz B.E., Xie G., Glavina Del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Chertkov O., Brettin T., Han C., Detter C., Pitluck S., Land M.L., Patel M., Ou M., Harbrucker R., Ingram L.O., Shanmugam K.T.
Stand. Genomic Sci. 5:331-340(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 36D1 EMBL AEP00709.1.
[3]Shanmugan K.T.
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 36D1 EMBL AEP00709.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003056 Genomic DNA. Translation: AEP00709.1.
RefSeqYP_004859489.1. NC_016023.1.

3D structure databases

ProteinModelPortalG2TIL8.
SMRG2TIL8. Positions 3-380.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEP00709; AEP00709; Bcoa_1503.
GeneID11171796.
KEGGbag:Bcoa_1503.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycBCOA345219:GH5A-1488-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG2TIL8_BACCO
AccessionPrimary (citable) accession number: G2TIL8
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)