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G2T5Z4 (G2T5Z4_ROSHA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. RuleBase RU004247 HAMAP-Rule MF_01201 SAAS SAAS009006

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site391Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2721Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1371Substrate By similarity HAMAP-Rule MF_01201
Binding site3201Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue391N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
G2T5Z4 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 98F8125DF2D51C07

FASTA38942,862
        10         20         30         40         50         60 
MESTLRRTWA EIDLDALAHN YHKLRERIGA DVKFLGVVKA DAYGHGSVQV SHLLQELGAD 

        70         80         90        100        110        120 
YLAVSSIDEA VELRLNDVTM PILILGHTPK EQVSRLIKYH ITQAVSCEAK ALEYSEEAVK 

       130        140        150        160        170        180 
CGGILKIHIK VDTGMSRLGY LCDGDHFETG VAGICHGCSL PGLDAEGIFT HFAVSDEPGE 

       190        200        210        220        230        240 
DCKKYTEHQF DLFMRVIEEV EKRLGRKFAL RHCANTGAVA RYPETFLDMV RPGLLLYGYG 

       250        260        270        280        290        300 
EFADELGLLP VMTLKTTVST IKIYPAGTAI SYGGIFKTEH TTRIGVVPYG YADGFFRCLS 

       310        320        330        340        350        360 
NRCALMTKEG PAPQRGKICM DMCMIDLTGK MGVDVGSEVE VFGKQNSIND LAALAGTIPY 

       370        380 
ELTCAVSKRV PRIYIRNGKV VEKELLLRG 

« Hide

References

[1]"Bi-directional cross-talk between a Clostridium symbiont, Roseburia hominis, the gut immune system and appetite regulation."
Mulder I.E., Aminov R.I., Travis A.J., Lan A., Gaboriau-Routhiau V., Garden K., Logan E., Delday M., Coutts A.G.P., Grant G., Patterson A.M., Cerf-Bensussan N., Kelly D.
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 16839 / NCIMB 14029 / A2-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003040 Genomic DNA. Translation: AEN98302.1.
RefSeqYP_004840234.1. NC_015977.1.

3D structure databases

ProteinModelPortalG2T5Z4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEN98302; AEN98302; RHOM_15980.
GeneID11148714.
KEGGrho:RHOM_15980.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycRHOM585394:GHYQ-3240-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG2T5Z4_ROSHA
AccessionPrimary (citable) accession number: G2T5Z4
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)