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Protein

Alanine racemase

Gene

RHOM_15980

Organism
Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (RHOM_15980)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Active sitei272Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei320Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRHOM585394:GHYQ-3240-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:RHOM_15980Imported
OrganismiRoseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)Imported
Taxonomic identifieri585394 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeRoseburia
Proteomesi
  • UP000008178 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi585394.RHOM_15980.

Structurei

3D structure databases

ProteinModelPortaliG2T5Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 375Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiISHFACA.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

G2T5Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTLRRTWA EIDLDALAHN YHKLRERIGA DVKFLGVVKA DAYGHGSVQV
60 70 80 90 100
SHLLQELGAD YLAVSSIDEA VELRLNDVTM PILILGHTPK EQVSRLIKYH
110 120 130 140 150
ITQAVSCEAK ALEYSEEAVK CGGILKIHIK VDTGMSRLGY LCDGDHFETG
160 170 180 190 200
VAGICHGCSL PGLDAEGIFT HFAVSDEPGE DCKKYTEHQF DLFMRVIEEV
210 220 230 240 250
EKRLGRKFAL RHCANTGAVA RYPETFLDMV RPGLLLYGYG EFADELGLLP
260 270 280 290 300
VMTLKTTVST IKIYPAGTAI SYGGIFKTEH TTRIGVVPYG YADGFFRCLS
310 320 330 340 350
NRCALMTKEG PAPQRGKICM DMCMIDLTGK MGVDVGSEVE VFGKQNSIND
360 370 380
LAALAGTIPY ELTCAVSKRV PRIYIRNGKV VEKELLLRG
Length:389
Mass (Da):42,862
Last modified:November 16, 2011 - v1
Checksum:i98F8125DF2D51C07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003040 Genomic DNA. Translation: AEN98302.1.
RefSeqiWP_014081223.1. NC_015977.1.

Genome annotation databases

EnsemblBacteriaiAEN98302; AEN98302; RHOM_15980.
KEGGirho:RHOM_15980.

Similar proteinsi

Entry informationi

Entry nameiG2T5Z4_ROSHA
AccessioniPrimary (citable) accession number: G2T5Z4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 27, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported