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G2T1L3

- G2T1L3_ROSHA

UniProt

G2T1L3 - G2T1L3_ROSHA

Protein

Isocitrate dehydrogenase [NADP]

Gene

RHOM_07865

Organism
Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganese
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganese
    Binding sitei325 – 3251NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi307 – 3126NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciRHOM585394:GHYQ-1599-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:RHOM_07865Imported
    OrganismiRoseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)Imported
    Taxonomic identifieri585394 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeRoseburia
    ProteomesiUP000008178: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2T1L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIKMTTPL VEMDGDEMTR ILWKMIKDEL LYPFIDLKTE YYDLGLEHRN    50
    ETDDQVTVDS ANATKKYGVA VKCATITPNA ARMTEYHLKE MWKSPNGTIR 100
    AMLDGTVFRA PIIVKGIEPC VKNWKKPITI ARHAYGDVYK ASEMKIPGPG 150
    KCELVYTAED GTETRELIHN FTGAGVVQGQ HNLCNSIESF ARSCFNYALD 200
    TKQDLWFATK DTISKKYDHT FKDIFQEIYD SEYAQKFKDA GITYFYTLID 250
    DAVARVMKSE GGYIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVTPDGKY 300
    EYEAAHGTVQ RHYYKHLKGE ETSTNSVATI FAWTGALRKR GELDGSHELE 350
    EFADKLEKAC VKTIEDGKMT KDLALITTIS NPVVLNSEDF IKAIRSTLEG 400
    MLLL 404
    Length:404
    Mass (Da):45,627
    Last modified:November 16, 2011 - v1
    Checksum:i8533DA2B9E600923
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003040 Genomic DNA. Translation: AEN96686.1.
    RefSeqiWP_014079725.1. NC_015977.1.
    YP_004838618.1. NC_015977.1.

    Genome annotation databases

    EnsemblBacteriaiAEN96686; AEN96686; RHOM_07865.
    GeneIDi11146774.
    KEGGirho:RHOM_07865.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003040 Genomic DNA. Translation: AEN96686.1 .
    RefSeqi WP_014079725.1. NC_015977.1.
    YP_004838618.1. NC_015977.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN96686 ; AEN96686 ; RHOM_07865 .
    GeneIDi 11146774.
    KEGGi rho:RHOM_07865.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci RHOM585394:GHYQ-1599-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bi-directional cross-talk between a Clostridium symbiont, Roseburia hominis, the gut immune system and appetite regulation."
      Mulder I.E., Aminov R.I., Travis A.J., Lan A., Gaboriau-Routhiau V., Garden K., Logan E., Delday M., Coutts A.G.P., Grant G., Patterson A.M., Cerf-Bensussan N., Kelly D.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16839 / NCIMB 14029 / A2-183Imported.

    Entry informationi

    Entry nameiG2T1L3_ROSHA
    AccessioniPrimary (citable) accession number: G2T1L3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3