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G2T1L3

- G2T1L3_ROSHA

UniProt

G2T1L3 - G2T1L3_ROSHA

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Protein

Isocitrate dehydrogenase [NADP]

Gene
RHOM_07865
Organism
Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarity
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei325 – 3251NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi307 – 3126NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRHOM585394:GHYQ-1599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:RHOM_07865Imported
OrganismiRoseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)Imported
Taxonomic identifieri585394 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeRoseburia
ProteomesiUP000008178: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2T1L3-1 [UniParc]FASTAAdd to Basket

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MEKIKMTTPL VEMDGDEMTR ILWKMIKDEL LYPFIDLKTE YYDLGLEHRN    50
ETDDQVTVDS ANATKKYGVA VKCATITPNA ARMTEYHLKE MWKSPNGTIR 100
AMLDGTVFRA PIIVKGIEPC VKNWKKPITI ARHAYGDVYK ASEMKIPGPG 150
KCELVYTAED GTETRELIHN FTGAGVVQGQ HNLCNSIESF ARSCFNYALD 200
TKQDLWFATK DTISKKYDHT FKDIFQEIYD SEYAQKFKDA GITYFYTLID 250
DAVARVMKSE GGYIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVTPDGKY 300
EYEAAHGTVQ RHYYKHLKGE ETSTNSVATI FAWTGALRKR GELDGSHELE 350
EFADKLEKAC VKTIEDGKMT KDLALITTIS NPVVLNSEDF IKAIRSTLEG 400
MLLL 404
Length:404
Mass (Da):45,627
Last modified:November 16, 2011 - v1
Checksum:i8533DA2B9E600923
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003040 Genomic DNA. Translation: AEN96686.1.
RefSeqiWP_014079725.1. NC_015977.1.
YP_004838618.1. NC_015977.1.

Genome annotation databases

EnsemblBacteriaiAEN96686; AEN96686; RHOM_07865.
GeneIDi11146774.
KEGGirho:RHOM_07865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003040 Genomic DNA. Translation: AEN96686.1 .
RefSeqi WP_014079725.1. NC_015977.1.
YP_004838618.1. NC_015977.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN96686 ; AEN96686 ; RHOM_07865 .
GeneIDi 11146774.
KEGGi rho:RHOM_07865.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci RHOM585394:GHYQ-1599-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bi-directional cross-talk between a Clostridium symbiont, Roseburia hominis, the gut immune system and appetite regulation."
    Mulder I.E., Aminov R.I., Travis A.J., Lan A., Gaboriau-Routhiau V., Garden K., Logan E., Delday M., Coutts A.G.P., Grant G., Patterson A.M., Cerf-Bensussan N., Kelly D.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16839 / NCIMB 14029 / A2-183.

Entry informationi

Entry nameiG2T1L3_ROSHA
AccessioniPrimary (citable) accession number: G2T1L3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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