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Protein

Ribonuclease 3

Gene

rnc

Organism
Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45MagnesiumBy similarity1
Active sitei49Sequence analysis1
Metal bindingi141MagnesiumBy similarity1
Active sitei144By similarity1
Metal bindingi144MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:RHOM_15125
OrganismiRoseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Taxonomic identifieri585394 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeRoseburia
Proteomesi
  • UP000008178 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004166131 – 357Ribonuclease 3Add BLAST357

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi585394.RHOM_15125

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155RNase IIIAdd BLAST150
Domaini198 – 267DRBM 1Add BLAST70
Domaini285 – 355DRBM 2Add BLAST71

Sequence similaritiesi

Belongs to the ribonuclease III family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410646M Bacteria
COG0571 LUCA
KOiK03685
OMAiLRECILE
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

G2SYN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKEIKFIQ DQIGYTFKNQ ELLVQAFTRR SYSMENGGQD NEVLEFIGDK
60 70 80 90 100
ALDFVVVKQL SEEFGHYSKK YQNWEKWGKT EETGTFISDL DEGELTEIKK
110 120 130 140 150
QLVQKNTLAD AIDNLGIAYY LIMGKGDVEK NIQDSLSVKE DLFEAILGAI
160 170 180 190 200
ALDSNWDIEA LQDSMNVMLN PGELMFDEDV NYVAEIQAWS SANSGNIPLH
210 220 230 240 250
CFYPTSMQGT WYMPRHHMCI YGKAEQDTHF ACEVLIPGID YHFVGYGRSK
260 270 280 290 300
NLARMDASRL AYEYLKDEDM LFSIRDEIDD PNYNDSIGQL EILARRGYFS
310 320 330 340 350
IPQYDFKETH DEDGNPVWNC KCSIKEKDTV TNGRSSSKKD AKKQAAYDML

TFVLEEE
Length:357
Mass (Da):41,045
Last modified:November 16, 2011 - v1
Checksum:i9D9FE4E68BD9B326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003040 Genomic DNA Translation: AEN98131.1

Genome annotation databases

EnsemblBacteriaiAEN98131; AEN98131; RHOM_15125
KEGGirho:RHOM_15125

Similar proteinsi

Entry informationi

Entry nameiRNC_ROSHA
AccessioniPrimary (citable) accession number: G2SYN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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