Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G2SYN4

- RNC_ROSHA

UniProt

G2SYN4 - RNC_ROSHA

Protein

Ribonuclease 3

Gene

rnc

Organism
Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.

    Cofactori

    Mg2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451MagnesiumBy similarity
    Active sitei49 – 491Sequence Analysis
    Metal bindingi141 – 1411MagnesiumBy similarity
    Active sitei144 – 1441By similarity
    Metal bindingi144 – 1441MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciRHOM585394:GHYQ-3069-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3 (EC:3.1.26.3)
    Alternative name(s):
    Ribonuclease III
    Short name:
    RNase III
    Gene namesi
    Name:rnc
    Ordered Locus Names:RHOM_15125
    OrganismiRoseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
    Taxonomic identifieri585394 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeRoseburia
    ProteomesiUP000008178: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Ribonuclease 3PRO_0000416613Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 155150RNase IIIAdd
    BLAST
    Domaini198 – 26770DRBM 1Add
    BLAST
    Domaini285 – 35571DRBM 2Add
    BLAST

    Sequence similaritiesi

    Contains 1 RNase III domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    KOiK03685.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 2 hits.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 2 hits.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    PROSITEiPS50137. DS_RBD. 2 hits.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2SYN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEKEIKFIQ DQIGYTFKNQ ELLVQAFTRR SYSMENGGQD NEVLEFIGDK    50
    ALDFVVVKQL SEEFGHYSKK YQNWEKWGKT EETGTFISDL DEGELTEIKK 100
    QLVQKNTLAD AIDNLGIAYY LIMGKGDVEK NIQDSLSVKE DLFEAILGAI 150
    ALDSNWDIEA LQDSMNVMLN PGELMFDEDV NYVAEIQAWS SANSGNIPLH 200
    CFYPTSMQGT WYMPRHHMCI YGKAEQDTHF ACEVLIPGID YHFVGYGRSK 250
    NLARMDASRL AYEYLKDEDM LFSIRDEIDD PNYNDSIGQL EILARRGYFS 300
    IPQYDFKETH DEDGNPVWNC KCSIKEKDTV TNGRSSSKKD AKKQAAYDML 350
    TFVLEEE 357
    Length:357
    Mass (Da):41,045
    Last modified:November 16, 2011 - v1
    Checksum:i9D9FE4E68BD9B326
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003040 Genomic DNA. Translation: AEN98131.1.
    RefSeqiWP_014081094.1. NC_015977.1.
    YP_004840063.1. NC_015977.1.

    Genome annotation databases

    EnsemblBacteriaiAEN98131; AEN98131; RHOM_15125.
    GeneIDi11148543.
    KEGGirho:RHOM_15125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003040 Genomic DNA. Translation: AEN98131.1 .
    RefSeqi WP_014081094.1. NC_015977.1.
    YP_004840063.1. NC_015977.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN98131 ; AEN98131 ; RHOM_15125 .
    GeneIDi 11148543.
    KEGGi rho:RHOM_15125.

    Phylogenomic databases

    KOi K03685.

    Enzyme and pathway databases

    BioCyci RHOM585394:GHYQ-3069-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 2 hits.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 2 hits.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    PROSITEi PS50137. DS_RBD. 2 hits.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bi-directional cross-talk between a Clostridium symbiont, Roseburia hominis, the gut immune system and appetite regulation."
      Mulder I.E., Aminov R.I., Travis A.J., Lan A., Gaboriau-Routhiau V., Garden K., Logan E., Delday M., Coutts A.G.P., Grant G., Patterson A.M., Cerf-Bensussan N., Kelly D.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16839 / NCIMB 14029 / A2-183.

    Entry informationi

    Entry nameiRNC_ROSHA
    AccessioniPrimary (citable) accession number: G2SYN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3