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G2SYN4

- RNC_ROSHA

UniProt

G2SYN4 - RNC_ROSHA

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Protein
Ribonuclease 3
Gene
rnc, RHOM_15125
Organism
Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+ By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Magnesium By similarity
Active sitei49 – 491 Reviewed prediction
Metal bindingi141 – 1411Magnesium By similarity
Active sitei144 – 1441 By similarity
Metal bindingi144 – 1441Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. rRNA binding Source: UniProtKB-KW
  3. ribonuclease III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciRHOM585394:GHYQ-3069-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:RHOM_15125
OrganismiRoseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183)
Taxonomic identifieri585394 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeRoseburia
ProteomesiUP000008178: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Ribonuclease 3UniRule annotation
PRO_0000416613Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150RNase III
Add
BLAST
Domaini198 – 26770DRBM 1
Add
BLAST
Domaini285 – 35571DRBM 2
Add
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK03685.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 2 hits.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50137. DS_RBD. 2 hits.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2SYN4-1 [UniParc]FASTAAdd to Basket

« Hide

MDEKEIKFIQ DQIGYTFKNQ ELLVQAFTRR SYSMENGGQD NEVLEFIGDK    50
ALDFVVVKQL SEEFGHYSKK YQNWEKWGKT EETGTFISDL DEGELTEIKK 100
QLVQKNTLAD AIDNLGIAYY LIMGKGDVEK NIQDSLSVKE DLFEAILGAI 150
ALDSNWDIEA LQDSMNVMLN PGELMFDEDV NYVAEIQAWS SANSGNIPLH 200
CFYPTSMQGT WYMPRHHMCI YGKAEQDTHF ACEVLIPGID YHFVGYGRSK 250
NLARMDASRL AYEYLKDEDM LFSIRDEIDD PNYNDSIGQL EILARRGYFS 300
IPQYDFKETH DEDGNPVWNC KCSIKEKDTV TNGRSSSKKD AKKQAAYDML 350
TFVLEEE 357
Length:357
Mass (Da):41,045
Last modified:November 16, 2011 - v1
Checksum:i9D9FE4E68BD9B326
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003040 Genomic DNA. Translation: AEN98131.1.
RefSeqiWP_014081094.1. NC_015977.1.
YP_004840063.1. NC_015977.1.

Genome annotation databases

EnsemblBacteriaiAEN98131; AEN98131; RHOM_15125.
GeneIDi11148543.
KEGGirho:RHOM_15125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003040 Genomic DNA. Translation: AEN98131.1 .
RefSeqi WP_014081094.1. NC_015977.1.
YP_004840063.1. NC_015977.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN98131 ; AEN98131 ; RHOM_15125 .
GeneIDi 11148543.
KEGGi rho:RHOM_15125.

Phylogenomic databases

KOi K03685.

Enzyme and pathway databases

BioCyci RHOM585394:GHYQ-3069-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 2 hits.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 2 hits.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
PROSITEi PS50137. DS_RBD. 2 hits.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bi-directional cross-talk between a Clostridium symbiont, Roseburia hominis, the gut immune system and appetite regulation."
    Mulder I.E., Aminov R.I., Travis A.J., Lan A., Gaboriau-Routhiau V., Garden K., Logan E., Delday M., Coutts A.G.P., Grant G., Patterson A.M., Cerf-Bensussan N., Kelly D.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16839 / NCIMB 14029 / A2-183.

Entry informationi

Entry nameiRNC_ROSHA
AccessioniPrimary (citable) accession number: G2SYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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