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G2SS12

- G2SS12_LACRR

UniProt

G2SS12 - G2SS12_LACRR

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Protein

Acetylornithine aminotransferase

Gene
argD, LRC_17180
Organism
Lactobacillus ruminis (strain ATCC 27782 / RF3)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351Pyridoxal phosphate; via carbonyl oxygen By similarityUniRule annotation
Binding sitei138 – 1381N2-acetyl-L-ornithine By similarityUniRule annotation
Binding sitei299 – 2991Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLRUM1069534:GJVX-1792-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:LRC_17180Imported
OrganismiLactobacillus ruminis (strain ATCC 27782 / RF3)Imported
Taxonomic identifieri1069534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001279: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni241 – 2444Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00823.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2SS12-1 [UniParc]FASTAAdd to Basket

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MESLYERSLK VFPPVAGRAT KIGAVSGQGS WLIDESGKKY LDFASGVAVV    50
NCGHNHPKVV EAVEKQLHEL VHGGHNVVYY PKYVELAEKL VARVGKPGEY 100
KVYFSNSGAE ANEGAVKLAL KATGRPGIIA FNGSFHGRTL LCASMTASSA 150
LYRENYEPEL PQVYHADFPD VWNTDLTEQE EIERCLNSVH KIFTNLILPE 200
RVACMVIEPV QGEGGYLPAP KRFIAELRKI CDEHGILLIF DEVQSGYGRT 250
GYLFAKDYYG VQPDIFTSAK AIANGIPLSA VIGKTEYMDK WLAGSHGGTF 300
GGNPLACAAG CAVLDVIDED FLEDVRKKGA FIRERLEDLK VTHSNVISSI 350
RGIGMMNGVE FRKDGKPLPK IVSKVQEIAL SKGLILLNCG TFHNVIRLIP 400
PLTATKEEIE QAIGIIDECL KEIEG 425
Length:425
Mass (Da):46,524
Last modified:November 16, 2011 - v1
Checksum:iA801693CFBC42698
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003032 Genomic DNA. Translation: AEN78960.1.
RefSeqiYP_004832896.1. NC_015975.1.

Genome annotation databases

EnsemblBacteriaiAEN78960; AEN78960; LRC_17180.
GeneIDi11140621.
KEGGilrm:LRC_17180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003032 Genomic DNA. Translation: AEN78960.1 .
RefSeqi YP_004832896.1. NC_015975.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN78960 ; AEN78960 ; LRC_17180 .
GeneIDi 11140621.
KEGGi lrm:LRC_17180.

Phylogenomic databases

KOi K00823.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .
BioCyci LRUM1069534:GJVX-1792-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts."
    Forde B.M., Neville B.A., O'Donnell M.M., Riboulet-Bisson E., Claesson M.J., Coghlan A., Ross R.P., O'Toole P.W.
    Microb. Cell Fact. 10:S13-S13(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27782 / RF3.

Entry informationi

Entry nameiG2SS12_LACRR
AccessioniPrimary (citable) accession number: G2SS12
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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