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G2SS12

- G2SS12_LACRR

UniProt

G2SS12 - G2SS12_LACRR

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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Lactobacillus ruminis (strain ATCC 27782 / RF3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Note: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei138 – 1381N2-acetyl-L-ornithineUniRule annotation
Binding sitei299 – 2991Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLRUM1069534:GJVX-1792-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:LRC_17180Imported
OrganismiLactobacillus ruminis (strain ATCC 27782 / RF3)Imported
Taxonomic identifieri1069534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001279: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni241 – 2444Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

KOiK00823.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2SS12-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MESLYERSLK VFPPVAGRAT KIGAVSGQGS WLIDESGKKY LDFASGVAVV
60 70 80 90 100
NCGHNHPKVV EAVEKQLHEL VHGGHNVVYY PKYVELAEKL VARVGKPGEY
110 120 130 140 150
KVYFSNSGAE ANEGAVKLAL KATGRPGIIA FNGSFHGRTL LCASMTASSA
160 170 180 190 200
LYRENYEPEL PQVYHADFPD VWNTDLTEQE EIERCLNSVH KIFTNLILPE
210 220 230 240 250
RVACMVIEPV QGEGGYLPAP KRFIAELRKI CDEHGILLIF DEVQSGYGRT
260 270 280 290 300
GYLFAKDYYG VQPDIFTSAK AIANGIPLSA VIGKTEYMDK WLAGSHGGTF
310 320 330 340 350
GGNPLACAAG CAVLDVIDED FLEDVRKKGA FIRERLEDLK VTHSNVISSI
360 370 380 390 400
RGIGMMNGVE FRKDGKPLPK IVSKVQEIAL SKGLILLNCG TFHNVIRLIP
410 420
PLTATKEEIE QAIGIIDECL KEIEG
Length:425
Mass (Da):46,524
Last modified:November 16, 2011 - v1
Checksum:iA801693CFBC42698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003032 Genomic DNA. Translation: AEN78960.1.
RefSeqiYP_004832896.1. NC_015975.1.

Genome annotation databases

EnsemblBacteriaiAEN78960; AEN78960; LRC_17180.
GeneIDi11140621.
KEGGilrm:LRC_17180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003032 Genomic DNA. Translation: AEN78960.1 .
RefSeqi YP_004832896.1. NC_015975.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN78960 ; AEN78960 ; LRC_17180 .
GeneIDi 11140621.
KEGGi lrm:LRC_17180.

Phylogenomic databases

KOi K00823.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .
BioCyci LRUM1069534:GJVX-1792-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts."
    Forde B.M., Neville B.A., O'Donnell M.M., Riboulet-Bisson E., Claesson M.J., Coghlan A., Ross R.P., O'Toole P.W.
    Microb. Cell Fact. 10:S13-S13(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27782 / RF3Imported.

Entry informationi

Entry nameiG2SS12_LACRR
AccessioniPrimary (citable) accession number: G2SS12
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3