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G2SS12

- G2SS12_LACRR

UniProt

G2SS12 - G2SS12_LACRR

Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Lactobacillus ruminis (strain ATCC 27782 / RF3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
    Binding sitei138 – 1381N2-acetyl-L-ornithineUniRule annotation
    Binding sitei299 – 2991Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLRUM1069534:GJVX-1792-MONOMER.
    UniPathwayiUPA00068; UER00109.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
    Short name:
    ACOATUniRule annotation
    Gene namesi
    Name:argDUniRule annotation
    Ordered Locus Names:LRC_17180Imported
    OrganismiLactobacillus ruminis (strain ATCC 27782 / RF3)Imported
    Taxonomic identifieri1069534 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001279: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni241 – 2444Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00823.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_01107. ArgD_aminotrans_3.
    InterProiIPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2SS12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLYERSLK VFPPVAGRAT KIGAVSGQGS WLIDESGKKY LDFASGVAVV    50
    NCGHNHPKVV EAVEKQLHEL VHGGHNVVYY PKYVELAEKL VARVGKPGEY 100
    KVYFSNSGAE ANEGAVKLAL KATGRPGIIA FNGSFHGRTL LCASMTASSA 150
    LYRENYEPEL PQVYHADFPD VWNTDLTEQE EIERCLNSVH KIFTNLILPE 200
    RVACMVIEPV QGEGGYLPAP KRFIAELRKI CDEHGILLIF DEVQSGYGRT 250
    GYLFAKDYYG VQPDIFTSAK AIANGIPLSA VIGKTEYMDK WLAGSHGGTF 300
    GGNPLACAAG CAVLDVIDED FLEDVRKKGA FIRERLEDLK VTHSNVISSI 350
    RGIGMMNGVE FRKDGKPLPK IVSKVQEIAL SKGLILLNCG TFHNVIRLIP 400
    PLTATKEEIE QAIGIIDECL KEIEG 425
    Length:425
    Mass (Da):46,524
    Last modified:November 16, 2011 - v1
    Checksum:iA801693CFBC42698
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003032 Genomic DNA. Translation: AEN78960.1.
    RefSeqiYP_004832896.1. NC_015975.1.

    Genome annotation databases

    EnsemblBacteriaiAEN78960; AEN78960; LRC_17180.
    GeneIDi11140621.
    KEGGilrm:LRC_17180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003032 Genomic DNA. Translation: AEN78960.1 .
    RefSeqi YP_004832896.1. NC_015975.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN78960 ; AEN78960 ; LRC_17180 .
    GeneIDi 11140621.
    KEGGi lrm:LRC_17180.

    Phylogenomic databases

    KOi K00823.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00109 .
    BioCyci LRUM1069534:GJVX-1792-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_01107. ArgD_aminotrans_3.
    InterProi IPR004636. AcOrn/SuccOrn_fam.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts."
      Forde B.M., Neville B.A., O'Donnell M.M., Riboulet-Bisson E., Claesson M.J., Coghlan A., Ross R.P., O'Toole P.W.
      Microb. Cell Fact. 10:S13-S13(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27782 / RF3Imported.

    Entry informationi

    Entry nameiG2SS12_LACRR
    AccessioniPrimary (citable) accession number: G2SS12
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3