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G2SQ61

- G2SQ61_LACRR

UniProt

G2SQ61 - G2SQ61_LACRR

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Protein
D-alanine--D-alanine ligase
Gene
ddl, LRC_13340
Organism
Lactobacillus ruminis (strain ATCC 27782 / RF3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi301 – 3011Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi314 – 3141Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi314 – 3141Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi316 – 3161Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi171 – 22656ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotations

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciLRUM1069534:GJVX-1385-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:LRC_13340Imported
OrganismiLactobacillus ruminis (strain ATCC 27782 / RF3)Imported
Taxonomic identifieri1069534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001279: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 347207ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2SQ61-1 [UniParc]FASTAAdd to Basket

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MSEKKLHIAL LFGGNSSEHD VSKRSAHTVF DALDKDKYEV SVFMFTKQGF    50
LLGNKDSMRI FDGEPEDAVV AEAIKDVDFS NPLANIQSLS EVKDIDLFIP 100
VIHGNMGEDG TVQSLFRLLN KPYIGSGIAS SAVSFDKDLT KQLLTYHGIR 150
NTKYVVVTPE NQSEYTYEKC AAELGETLFV KPARQGSSVG IYKVSNKEEF 200
DKAIQDGFHY DFKVLVEETI ANPREVECSV LGNRDIKASK LGAIRIPAED 250
AFYDYNNKFV DASGVVFEIP VELPEKLTKE IQQMSLDAFR VLGNRGLARM 300
DFLVDENDVP YFGEVNTLPG FTNISLYPQL WAVSGISYKD LLDRLIQLAF 350
DEFEDNAKLH YDFVELGSEK LGKGLLTDED KK 382
Length:382
Mass (Da):42,810
Last modified:November 16, 2011 - v1
Checksum:i23DF8AAB13716E13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003032 Genomic DNA. Translation: AEN78587.1.
RefSeqiWP_014073754.1. NC_015975.1.
YP_004832523.1. NC_015975.1.

Genome annotation databases

EnsemblBacteriaiAEN78587; AEN78587; LRC_13340.
GeneIDi11141183.
KEGGilrm:LRC_13340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003032 Genomic DNA. Translation: AEN78587.1 .
RefSeqi WP_014073754.1. NC_015975.1.
YP_004832523.1. NC_015975.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN78587 ; AEN78587 ; LRC_13340 .
GeneIDi 11141183.
KEGGi lrm:LRC_13340.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LRUM1069534:GJVX-1385-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts."
    Forde B.M., Neville B.A., O'Donnell M.M., Riboulet-Bisson E., Claesson M.J., Coghlan A., Ross R.P., O'Toole P.W.
    Microb. Cell Fact. 10:S13-S13(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27782 / RF3.

Entry informationi

Entry nameiG2SQ61_LACRR
AccessioniPrimary (citable) accession number: G2SQ61
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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