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Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Enterobacter asburiae (strain LF7a)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1518)/N6-dimethyladenine(1519) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei20S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei45S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei66S-adenosyl-L-methionineUniRule annotation1
Binding sitei91S-adenosyl-L-methionineUniRule annotation1
Binding sitei113S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, RNA-bindingUniRule annotationSAAS annotation, Transferase
Biological processrRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:Entas_0653Imported
OrganismiEnterobacter asburiae (strain LF7a)Imported
Taxonomic identifieri640513 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
Proteomesi
  • UP000008527 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi640513.Entas_0653

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 198rADcInterPro annotationAdd BLAST174

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105D1X Bacteria
COG0030 LUCA
KOiK02528
OMAiKRFGQHW
OrthoDBiPOG091H02E3

Family and domain databases

Gene3Di1.10.8.100, 1 hit
HAMAPiMF_00607 16SrRNA_methyltr_A, 1 hit
InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR023165 rRNA_Ade_diMease-like
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR011530 rRNA_adenine_dimethylase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00755 ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

G2S5R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRVHQGHL ARKRFGQNFL NDQFVIESIV SAINPQKGQA MVEIGPGLAA
60 70 80 90 100
LTEPVGERLD ELTVIELDRD LAARLQTHPF LGPKLTIYQQ DAMTMNFGEL
110 120 130 140 150
SEKMGQPLRV FGNLPYNIST PLMFHLFSYT DAIADMHFML QKEVVNRMVA
160 170 180 190 200
GPNSKAYGRL SVMAQYFCNV IPVLEVPPSA FTPPPKVDSA VVRLVPHKVK
210 220 230 240 250
PYPVKELRVL SRITTEAFNQ RRKTIRNSLS NSFSVEVLAE LGIDPAMRAE
260 270
NISVEQYCKL ANYISENAPP KES
Length:273
Mass (Da):30,598
Last modified:November 16, 2011 - v1
Checksum:i8EAA07C1D86679B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003026 Genomic DNA Translation: AEN63404.1
RefSeqiWP_014068864.1, NC_015968.1

Genome annotation databases

EnsemblBacteriaiAEN63404; AEN63404; Entas_0653
KEGGieas:Entas_0653

Similar proteinsi

Entry informationi

Entry nameiG2S5R4_ENTAL
AccessioniPrimary (citable) accession number: G2S5R4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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