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G2S5R4

- G2S5R4_ENTAL

UniProt

G2S5R4 - G2S5R4_ENTAL

Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Enterobacter asburiae (strain LF7a)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotationSAAS annotation

    Catalytic activityi

    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei18 – 181S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei20 – 201S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei45 – 451S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei66 – 661S-adenosyl-L-methionineUniRule annotation
    Binding sitei91 – 911S-adenosyl-L-methionineUniRule annotation
    Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW
    3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    rRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    RNA-bindingUniRule annotationSAAS annotation, S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciEASB640513:GKDM-671-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
    16S rRNA dimethyladenosine transferaseUniRule annotation
    16S rRNA dimethylaseUniRule annotation
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
    Gene namesi
    Name:rsmAUniRule annotation
    Synonyms:ksgAUniRule annotation
    Ordered Locus Names:Entas_0653Imported
    OrganismiEnterobacter asburiae (strain LF7a)Imported
    Taxonomic identifieri640513 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
    ProteomesiUP000008527: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

    Phylogenomic databases

    KOiK02528.
    OMAiDHVMVEI.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2S5R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNRVHQGHL ARKRFGQNFL NDQFVIESIV SAINPQKGQA MVEIGPGLAA    50
    LTEPVGERLD ELTVIELDRD LAARLQTHPF LGPKLTIYQQ DAMTMNFGEL 100
    SEKMGQPLRV FGNLPYNIST PLMFHLFSYT DAIADMHFML QKEVVNRMVA 150
    GPNSKAYGRL SVMAQYFCNV IPVLEVPPSA FTPPPKVDSA VVRLVPHKVK 200
    PYPVKELRVL SRITTEAFNQ RRKTIRNSLS NSFSVEVLAE LGIDPAMRAE 250
    NISVEQYCKL ANYISENAPP KES 273
    Length:273
    Mass (Da):30,598
    Last modified:November 16, 2011 - v1
    Checksum:i8EAA07C1D86679B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003026 Genomic DNA. Translation: AEN63404.1.
    RefSeqiWP_014068864.1. NC_015968.1.
    YP_004827189.1. NC_015968.1.

    Genome annotation databases

    EnsemblBacteriaiAEN63404; AEN63404; Entas_0653.
    GeneIDi11108982.
    KEGGieas:Entas_0653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003026 Genomic DNA. Translation: AEN63404.1 .
    RefSeqi WP_014068864.1. NC_015968.1.
    YP_004827189.1. NC_015968.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN63404 ; AEN63404 ; Entas_0653 .
    GeneIDi 11108982.
    KEGGi eas:Entas_0653.

    Phylogenomic databases

    KOi K02528.
    OMAi DHVMVEI.

    Enzyme and pathway databases

    BioCyci EASB640513:GKDM-671-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Enterobacter asburiae LF7a."
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., van der Lelie D., Woyke T.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LF7aImported.

    Entry informationi

    Entry nameiG2S5R4_ENTAL
    AccessioniPrimary (citable) accession number: G2S5R4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3