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G2S5R4

- G2S5R4_ENTAL

UniProt

G2S5R4 - G2S5R4_ENTAL

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Protein

Ribosomal RNA small subunit methyltransferase A

Gene
rsmA, ksgA, Entas_0653
Organism
Enterobacter asburiae (strain LF7a)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits By similarity.UniRule annotationSAAS annotations

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei20 – 201S-adenosyl-L-methionine; via amide nitrogen By similarityUniRule annotation
Binding sitei45 – 451S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei66 – 661S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei91 – 911S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei113 – 1131S-adenosyl-L-methionine By similarityUniRule annotation

GO - Molecular functioni

  1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW
  3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

rRNA processingUniRule annotationSAAS annotations

Keywords - Ligandi

RNA-bindingUniRule annotationSAAS annotations, S-adenosyl-L-methionineUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciEASB640513:GKDM-671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
16S rRNA dimethyladenosine transferase
16S rRNA dimethylase
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:Entas_0653Imported
OrganismiEnterobacter asburiae (strain LF7a)Imported
Taxonomic identifieri640513 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000008527: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK02528.
OMAiDHVMVEI.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A.
InterProiIPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR001737. rRNA_Ade_methylase_transferase.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2S5R4-1 [UniParc]FASTAAdd to Basket

« Hide

MTNRVHQGHL ARKRFGQNFL NDQFVIESIV SAINPQKGQA MVEIGPGLAA    50
LTEPVGERLD ELTVIELDRD LAARLQTHPF LGPKLTIYQQ DAMTMNFGEL 100
SEKMGQPLRV FGNLPYNIST PLMFHLFSYT DAIADMHFML QKEVVNRMVA 150
GPNSKAYGRL SVMAQYFCNV IPVLEVPPSA FTPPPKVDSA VVRLVPHKVK 200
PYPVKELRVL SRITTEAFNQ RRKTIRNSLS NSFSVEVLAE LGIDPAMRAE 250
NISVEQYCKL ANYISENAPP KES 273
Length:273
Mass (Da):30,598
Last modified:November 16, 2011 - v1
Checksum:i8EAA07C1D86679B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003026 Genomic DNA. Translation: AEN63404.1.
RefSeqiWP_014068864.1. NC_015968.1.
YP_004827189.1. NC_015968.1.

Genome annotation databases

EnsemblBacteriaiAEN63404; AEN63404; Entas_0653.
GeneIDi11108982.
KEGGieas:Entas_0653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003026 Genomic DNA. Translation: AEN63404.1 .
RefSeqi WP_014068864.1. NC_015968.1.
YP_004827189.1. NC_015968.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN63404 ; AEN63404 ; Entas_0653 .
GeneIDi 11108982.
KEGGi eas:Entas_0653.

Phylogenomic databases

KOi K02528.
OMAi DHVMVEI.

Enzyme and pathway databases

BioCyci EASB640513:GKDM-671-MONOMER.

Family and domain databases

Gene3Di 1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPi MF_00607. 16SrRNA_methyltr_A.
InterProi IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR001737. rRNA_Ade_methylase_transferase.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11727. PTHR11727. 1 hit.
Pfami PF00398. RrnaAD. 1 hit.
[Graphical view ]
SMARTi SM00650. rADc. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00755. ksgA. 1 hit.
PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Enterobacter asburiae LF7a."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., van der Lelie D., Woyke T.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LF7a.

Entry informationi

Entry nameiG2S5R4_ENTAL
AccessioniPrimary (citable) accession number: G2S5R4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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