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Protein

Histone deacetylase

Gene

THITE_46814

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateUniRule annotation1
Active sitei200Proton acceptorUniRule annotation1
Binding sitei208Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi235Divalent metal cationUniRule annotation1
Metal bindingi237Divalent metal cationUniRule annotation1
Metal bindingi329Divalent metal cationUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:THITE_46814Imported
OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
Taxonomic identifieri578455 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
Proteomesi
  • UP000008181 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi578455.XP_003656726.1.

Structurei

3D structure databases

ProteinModelPortaliG2RFA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 383Hist_deacetylInterPro annotationAdd BLAST301

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
KOiK11483.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

G2RFA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSAYRYRP PKPNYLPHDI EVDDPIVEEY TIPLGKADDR ENAIFFNKMK
60 70 80 90 100
LAAQEYGIVR PKGYTVSYHA TPEMEKHHFG QTHPMKPWRL TLTKSLVTAY
110 120 130 140 150
GMPFAMDNYL TREATYEELN SFHSNDYLDY LITAAPEDQP RDIDNPDKEV
160 170 180 190 200
KFNLGGSDCP LFHGLYNYCS MSAGSSLDAA RKICSNQSDI AIAWGGGLHH
210 220 230 240 250
AKRSEASGFC YINDIVLAIL QLLRIYPRVL YIDIDVHHGD GVEEAFFSTD
260 270 280 290 300
RVMTVSFHKY QPDQFFPGTG ALEDNGPKNE HNPGAHHAIN VPLNDGITDE
310 320 330 340 350
QYEALFKNII GPINERYRPS AIALQCGADS LAGDRLGRFN LRVQGHGACV
360 370 380 390 400
RYCKSLGLPM ILFGGGGYTP RNVARAWAYE TSIAIGADTR IPETIPEHTP
410 420 430 440 450
WRAHFIHDTL FPSLEQSMHE PRHNRNSEKR LREIVAHVHE QLRFVEHAPS
460 470 480 490
VQSQIIPPDL EGIRDEVEAR LKEESEEKDD GLRKIREEGV GQAMEF
Length:496
Mass (Da):56,105
Last modified:November 16, 2011 - v1
Checksum:i2ABFAA87E4EE8842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003013 Genomic DNA. Translation: AEO70390.1.
RefSeqiXP_003656726.1. XM_003656678.1.

Genome annotation databases

EnsemblFungiiAEO70390; AEO70390; THITE_46814.
GeneIDi11522540.
KEGGittt:THITE_46814.

Similar proteinsi

Entry informationi

Entry nameiG2RFA7_THITE
AccessioniPrimary (citable) accession number: G2RFA7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 30, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported