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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

THITE_61645

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (THITE_2122016), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (THITE_61645)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:THITE_61645Imported
OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
Taxonomic identifieri578455 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
Proteomesi
  • UP000008181 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi578455.XP_003656612.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 458FAD_binding_2InterPro annotationAdd BLAST396
Domaini513 – 648Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
KOiK00234
OrthoDBiEOG092C17LB

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

G2REZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSMAWRRL AAAPALSRAF RNPTRAFSTT RPVARVIANG PLRAKEASPF
60 70 80 90 100
VSNKYPVIDH EYDAIVVGAG GAGLRAAFGL AEAGFNTACI SKLFPTRSHT
110 120 130 140 150
VAAQGGINAA LGNMHEDDWR WHMYDTVKGS DWLGDQDAIH YMTREAPASI
160 170 180 190 200
IELEHYGCPF SRTEDGKIYQ RAFGGQSQKY GKGGQAYRCC AAADRTGHAL
210 220 230 240 250
LHTLYGQSLR HNTNYFIEYF AIDLIMQDGE CRGVLAYNQE DGTLHRFFAN
260 270 280 290 300
NTVLATGGYG RAYFSCTSAH TCTGDGMAMV ARAGLPNQDL EFVQFHPTGI
310 320 330 340 350
YGAGCLITEG ARGEGGYLLN SEGERFMERY APTAKDLASR DVVSRSMTLE
360 370 380 390 400
IREGRGVGPE KDHIYLQLSH LPAEILAERL PGISETAGIF AGVDVRKQPI
410 420 430 440 450
PVLPTVHYNM GGIPTRYTGE VLTVDEQGND KVVPGLFACG EAACVSVHGA
460 470 480 490 500
NRLGANSLLD LVVFGRAVSH TIRDKFTPGA PLKPVEADAG AQSIETLDKI
510 520 530 540 550
RTSNGPKSTA EIRLAMQKTM QREVSVFRTQ ESLDEGVRQI TEVDKMFSQV
560 570 580 590 600
GIKDRSMIWN SDLVETLELR NLLTCATQTA VSAANRKESR GAHAREDYPE
610 620 630 640
RDDENWMKHT LSWQKTPHGP VELKYRRVIS TTLDENECKP VPPFKRVY
Length:648
Mass (Da):71,178
Last modified:November 16, 2011 - v1
Checksum:i4EC1CC0CBF5F9DEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003013 Genomic DNA Translation: AEO70276.1
RefSeqiXP_003656612.1, XM_003656564.1

Genome annotation databases

EnsemblFungiiAEO70276; AEO70276; THITE_61645
GeneIDi11522581
KEGGittt:THITE_61645

Entry informationi

Entry nameiG2REZ3_THITE
AccessioniPrimary (citable) accession number: G2REZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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