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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

THITE_2119121

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei365 – 3651S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K79 specific) Source: InterPro

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA damage checkpoint Source: InterPro
  3. DNA repair Source: InterPro
  4. regulation of cell cycle Source: InterPro
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:THITE_2119121Imported
OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
Taxonomic identifieri578455 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
ProteomesiUP000008181 Componenti: Chromosome 4

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni316 – 3194S-adenosyl-L-methionine bindingUniRule annotation
Regioni339 – 34810S-adenosyl-L-methionine bindingUniRule annotation
Regioni401 – 4022S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2RBD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFSKRSKF RVPTEVRRIK QVVEPVAQPK TARAAILGST AAPAAASHSV
60 70 80 90 100
SRSSHGTPRA SPKPASSSRT QALQSAMSSP ELRRSSTTTS RKRRAAYTNS
110 120 130 140 150
PLNDSDPESD DEDWRETLDP SKRRKRAHTE DPARQLRHPR LWAGQNEEED
160 170 180 190 200
ELGIVHAVEV ASLADKCRPV MGLEEDEVGV RLRYPGANYL ERYELVWGRD
210 220 230 240 250
KIDGARDIME VVNLVGSIYL TDAQAKPFLD QDHGIYRRLE KSKNTKDGKG
260 270 280 290 300
FKAALQEYNE QLLALQKKGA IAQNIDAMRG VPRELVETIL RQVYDRTVAP
310 320 330 340 350
KVELLAKYQN GTDNVYGELL HPFVSDIFDR TKLTSEMVFV DLGSGVGNVT
360 370 380 390 400
LQAALERGCE SWGCEMMENA CNLAEAQQKE FAARCQLWGI APGKVHLERG
410 420 430 440 450
DFCKNERTLA ALKRADVVLV NNQAFTSELN GTLVNMFLDL KVGCKIVSLK
460 470 480 490
TFVHDNKTAA NDVAASILDV EHFSYPGGYV SWTAAPGTFC ISTRK
Length:495
Mass (Da):54,951
Last modified:November 16, 2011 - v1
Checksum:i38AAE565CFBDD62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003012 Genomic DNA. Translation: AEO69101.1.
RefSeqiXP_003655437.1. XM_003655389.1.

Genome annotation databases

GeneIDi11520350.
KEGGittt:THITE_2119121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003012 Genomic DNA. Translation: AEO69101.1.
RefSeqiXP_003655437.1. XM_003655389.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11520350.
KEGGittt:THITE_2119121.

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 38088 / NRRL 8126Imported.

Entry informationi

Entry nameiG2RBD0_THITE
AccessioniPrimary (citable) accession number: G2RBD0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 1, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.