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G2RBD0 (G2RBD0_THITE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
ORF Names:THITE_2119121 EMBL AEO69101.1
OrganismThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense) [Complete proteome]
Taxonomic identifier578455 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region316 – 3194S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region339 – 34810S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region401 – 4022S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site3651S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
G2RBD0 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 38AAE565CFBDD62D

FASTA49554,951
        10         20         30         40         50         60 
MSIFSKRSKF RVPTEVRRIK QVVEPVAQPK TARAAILGST AAPAAASHSV SRSSHGTPRA 

        70         80         90        100        110        120 
SPKPASSSRT QALQSAMSSP ELRRSSTTTS RKRRAAYTNS PLNDSDPESD DEDWRETLDP 

       130        140        150        160        170        180 
SKRRKRAHTE DPARQLRHPR LWAGQNEEED ELGIVHAVEV ASLADKCRPV MGLEEDEVGV 

       190        200        210        220        230        240 
RLRYPGANYL ERYELVWGRD KIDGARDIME VVNLVGSIYL TDAQAKPFLD QDHGIYRRLE 

       250        260        270        280        290        300 
KSKNTKDGKG FKAALQEYNE QLLALQKKGA IAQNIDAMRG VPRELVETIL RQVYDRTVAP 

       310        320        330        340        350        360 
KVELLAKYQN GTDNVYGELL HPFVSDIFDR TKLTSEMVFV DLGSGVGNVT LQAALERGCE 

       370        380        390        400        410        420 
SWGCEMMENA CNLAEAQQKE FAARCQLWGI APGKVHLERG DFCKNERTLA ALKRADVVLV 

       430        440        450        460        470        480 
NNQAFTSELN GTLVNMFLDL KVGCKIVSLK TFVHDNKTAA NDVAASILDV EHFSYPGGYV 

       490 
SWTAAPGTFC ISTRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003012 Genomic DNA. Translation: AEO69101.1.
RefSeqXP_003655437.1. XM_003655389.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11520350.
KEGGttt:THITE_2119121.

Phylogenomic databases

KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG2RBD0_THITE
AccessionPrimary (citable) accession number: G2RBD0
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)