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G2RBD0

- G2RBD0_THITE

UniProt

G2RBD0 - G2RBD0_THITE

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

THITE_2119121

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei365 – 3651S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:THITE_2119121Imported
    OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
    Taxonomic identifieri578455 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
    ProteomesiUP000008181: Chromosome 4

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni316 – 3194S-adenosyl-L-methionine bindingUniRule annotation
    Regioni339 – 34810S-adenosyl-L-methionine bindingUniRule annotation
    Regioni401 – 4022S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2RBD0-1 [UniParc]FASTAAdd to Basket

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    MSIFSKRSKF RVPTEVRRIK QVVEPVAQPK TARAAILGST AAPAAASHSV    50
    SRSSHGTPRA SPKPASSSRT QALQSAMSSP ELRRSSTTTS RKRRAAYTNS 100
    PLNDSDPESD DEDWRETLDP SKRRKRAHTE DPARQLRHPR LWAGQNEEED 150
    ELGIVHAVEV ASLADKCRPV MGLEEDEVGV RLRYPGANYL ERYELVWGRD 200
    KIDGARDIME VVNLVGSIYL TDAQAKPFLD QDHGIYRRLE KSKNTKDGKG 250
    FKAALQEYNE QLLALQKKGA IAQNIDAMRG VPRELVETIL RQVYDRTVAP 300
    KVELLAKYQN GTDNVYGELL HPFVSDIFDR TKLTSEMVFV DLGSGVGNVT 350
    LQAALERGCE SWGCEMMENA CNLAEAQQKE FAARCQLWGI APGKVHLERG 400
    DFCKNERTLA ALKRADVVLV NNQAFTSELN GTLVNMFLDL KVGCKIVSLK 450
    TFVHDNKTAA NDVAASILDV EHFSYPGGYV SWTAAPGTFC ISTRK 495
    Length:495
    Mass (Da):54,951
    Last modified:November 16, 2011 - v1
    Checksum:i38AAE565CFBDD62D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003012 Genomic DNA. Translation: AEO69101.1.
    RefSeqiXP_003655437.1. XM_003655389.1.

    Genome annotation databases

    GeneIDi11520350.
    KEGGittt:THITE_2119121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003012 Genomic DNA. Translation: AEO69101.1 .
    RefSeqi XP_003655437.1. XM_003655389.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11520350.
    KEGGi ttt:THITE_2119121.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 38088 / NRRL 8126Imported.

    Entry informationi

    Entry nameiG2RBD0_THITE
    AccessioniPrimary (citable) accession number: G2RBD0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3