SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G2RAD0

- G2RAD0_THITE

UniProt

G2RAD0 - G2RAD0_THITE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eukaryotic translation initiation factor 6

Gene
TIF6, THITE_2079729
Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity.UniRule annotation

GO - Molecular functioni

  1. ribosomal large subunit binding Source: UniProtKB-HAMAP
  2. ribosome binding Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mature ribosome assembly Source: UniProtKB-HAMAP
  2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
  3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:TIF6UniRule annotation
ORF Names:THITE_2079729Imported
OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Taxonomic identifieri578455 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
ProteomesiUP000008181: Chromosome 4

Subcellular locationi

Cytoplasm. Nucleusnucleolus
Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphoserine; by CK1 By similarityUniRule annotation
Modified residuei175 – 1751Phosphoserine; by CK1 By similarityUniRule annotation

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

KOiK03264.
OrthoDBiEOG7TTQKB.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

G2RAD0-1 [UniParc]FASTAAdd to Basket

« Hide

MAVRAQFENS NEVGVFATLT NSYALVAIGA SENFYSVFEA ELQDVIPICR    50
TTIAGTRIIG RLTAGNRKGL LVPTSTTDQE LQHLRNSLPD EIRIQRIEER 100
LSALGNVIVT NDHTALIHPD LERETEEIVA DVLGVEVFRQ TVADHVLVGS 150
YMALSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVIGGGMVVN 200
DWMAVTGLDT TAPELSVIES VFRLGEGAAP GNINTSMKDT IVESFY 246
Length:246
Mass (Da):26,533
Last modified:November 16, 2011 - v1
Checksum:i83D5F795D791FDA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003012 Genomic DNA. Translation: AEO68862.1.
RefSeqiXP_003655198.1. XM_003655150.1.

Genome annotation databases

GeneIDi11524388.
KEGGittt:THITE_2079729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003012 Genomic DNA. Translation: AEO68862.1 .
RefSeqi XP_003655198.1. XM_003655150.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11524388.
KEGGi ttt:THITE_2079729.

Phylogenomic databases

KOi K03264.
OrthoDBi EOG7TTQKB.

Family and domain databases

HAMAPi MF_00032. eIF_6.
InterProi IPR002769. eIF6.
[Graphical view ]
PANTHERi PTHR10784. PTHR10784. 1 hit.
Pfami PF01912. eIF-6. 1 hit.
[Graphical view ]
PIRSFi PIRSF006413. IF-6. 1 hit.
SMARTi SM00654. eIF6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00323. eIF-6. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 38088 / NRRL 8126.

Entry informationi

Entry nameiG2RAD0_THITE
AccessioniPrimary (citable) accession number: G2RAD0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 9, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi