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G2RAD0

- G2RAD0_THITE

UniProt

G2RAD0 - G2RAD0_THITE

Protein

Eukaryotic translation initiation factor 6

Gene

TIF6

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

    GO - Molecular functioni

    1. ribosomal large subunit binding Source: UniProtKB-HAMAP
    2. ribosome binding Source: InterPro
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mature ribosome assembly Source: UniProtKB-HAMAP
    2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
    3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factorUniRule annotation

    Keywords - Biological processi

    Protein biosynthesis, Ribosome biogenesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 6UniRule annotation
    Short name:
    eIF-6UniRule annotation
    Gene namesi
    Name:TIF6UniRule annotation
    ORF Names:THITE_2079729Imported
    OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
    Taxonomic identifieri578455 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
    ProteomesiUP000008181: Chromosome 4

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleusnucleolus UniRule annotation
    Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotation
    Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotation

    Post-translational modificationi

    Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Interactioni

    Subunit structurei

    Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-6 family.UniRule annotation

    Phylogenomic databases

    KOiK03264.
    OrthoDBiEOG7TTQKB.

    Family and domain databases

    HAMAPiMF_00032. eIF_6.
    InterProiIPR002769. eIF6.
    [Graphical view]
    PANTHERiPTHR10784. PTHR10784. 1 hit.
    PfamiPF01912. eIF-6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006413. IF-6. 1 hit.
    SMARTiSM00654. eIF6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00323. eIF-6. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G2RAD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRAQFENS NEVGVFATLT NSYALVAIGA SENFYSVFEA ELQDVIPICR    50
    TTIAGTRIIG RLTAGNRKGL LVPTSTTDQE LQHLRNSLPD EIRIQRIEER 100
    LSALGNVIVT NDHTALIHPD LERETEEIVA DVLGVEVFRQ TVADHVLVGS 150
    YMALSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVIGGGMVVN 200
    DWMAVTGLDT TAPELSVIES VFRLGEGAAP GNINTSMKDT IVESFY 246
    Length:246
    Mass (Da):26,533
    Last modified:November 16, 2011 - v1
    Checksum:i83D5F795D791FDA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003012 Genomic DNA. Translation: AEO68862.1.
    RefSeqiXP_003655198.1. XM_003655150.1.

    Genome annotation databases

    GeneIDi11524388.
    KEGGittt:THITE_2079729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003012 Genomic DNA. Translation: AEO68862.1 .
    RefSeqi XP_003655198.1. XM_003655150.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11524388.
    KEGGi ttt:THITE_2079729.

    Phylogenomic databases

    KOi K03264.
    OrthoDBi EOG7TTQKB.

    Family and domain databases

    HAMAPi MF_00032. eIF_6.
    InterProi IPR002769. eIF6.
    [Graphical view ]
    PANTHERi PTHR10784. PTHR10784. 1 hit.
    Pfami PF01912. eIF-6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006413. IF-6. 1 hit.
    SMARTi SM00654. eIF6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00323. eIF-6. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 38088 / NRRL 8126Imported.

    Entry informationi

    Entry nameiG2RAD0_THITE
    AccessioniPrimary (citable) accession number: G2RAD0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3