G2RAD0 (G2RAD0_THITE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 6 HAMAP-Rule MF_03132
Short name=eIF-6 HAMAP-Rule MF_03132

Gene names

Name:	TIF6 HAMAP-Rule MF_03132
ORF Names:	THITE_2079729 EMBL AEO68862.1

Organism

Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense) [Complete proteome]

Taxonomic identifier

578455 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Thielavia › Thielavia terrestris

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity. HAMAP-Rule MF_03132
Subunit structure	Monomer. Associates with the 60S ribosomal subunit By similarity. HAMAP-Rule MF_03132
Subcellular location	Cytoplasm. Nucleus › nucleolus. Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity. HAMAP-Rule MF_03132
Post-translational modification	Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity. HAMAP-Rule MF_03132
Sequence similarities	Belongs to the eIF-6 family. HAMAP-Rule MF_03132

Ontologies

Keywords
Biological process	Protein biosynthesis Ribosome biogenesis HAMAP-Rule MF_03132
Cellular component	Cytoplasm HAMAP-Rule MF_03132 Nucleus HAMAP-Rule MF_03132
Molecular function	Initiation factor HAMAP-Rule MF_03132
PTM	Phosphoprotein HAMAP-Rule MF_03132
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mature ribosome assembly Inferred from electronic annotation. Source: HAMAP ribosomal large subunit biogenesis Inferred from electronic annotation. Source: HAMAP ribosomal subunit export from nucleus Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribosomal large subunit binding Inferred from electronic annotation. Source: HAMAP ribosome binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	174	1	Phosphoserine; by CK1 By similarity HAMAP-Rule MF_03132
	Modified residue	175	1	Phosphoserine; by CK1 By similarity HAMAP-Rule MF_03132

Sequences

	Sequence		Length	Mass (Da)
	G2RAD0 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: 83D5F795D791FDA6	FASTA	246	26,533
	10 20 30 40 50 60 MAVRAQFENS NEVGVFATLT NSYALVAIGA SENFYSVFEA ELQDVIPICR TTIAGTRIIG 70 80 90 100 110 120 RLTAGNRKGL LVPTSTTDQE LQHLRNSLPD EIRIQRIEER LSALGNVIVT NDHTALIHPD 130 140 150 160 170 180 LERETEEIVA DVLGVEVFRQ TVADHVLVGS YMALSNQGGL VHPKTSIQDQ DELSSLLQVP 190 200 210 220 230 240 LVAGSVNRGS NVIGGGMVVN DWMAVTGLDT TAPELSVIES VFRLGEGAAP GNINTSMKDT IVESFY

References

[1]

"Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris." Berka R.M., Grigoriev I.V., Otillar R., Salamov A., Grimwood J., Reid I., Ishmael N., John T., Darmond C., Moisan M.C., Henrissat B., Coutinho P.M., Lombard V., Natvig D.O., Lindquist E., Schmutz J., Lucas S., Harris P. , Powlowski J., Bellemare A., Taylor D., Butler G., de Vries R.P., Allijn I.E., van den Brink J., Ushinsky S., Storms R., Powell A.J., Paulsen I.T., Elbourne L.D., Baker S.E., Magnuson J., Laboissiere S., Clutterbuck A.J., Martinez D., Wogulis M., de Leon A.L., Rey M.W., Tsang A. Nat. Biotechnol. 29:922-927(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38088 / NRRL 8126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003012 Genomic DNA. Translation: AEO68862.1.
RefSeq	XP_003655198.1. XM_003655150.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	11524388.
KEGG	ttt:THITE_2079729.
Phylogenomic databases
KO	K03264.
Family and domain databases
HAMAP	MF_00032. eIF_6.
InterPro	IPR002769. eIF6. [Graphical view]
PANTHER	PTHR10784. PTHR10784. 1 hit.
Pfam	PF01912. eIF-6. 1 hit. [Graphical view]
PIRSF	PIRSF006413. IF-6. 1 hit.
SMART	SM00654. eIF6. 1 hit. [Graphical view]
TIGRFAMs	TIGR00323. eIF-6. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G2RAD0_THITE

Accession

Primary (citable) accession number: G2RAD0

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	January 9, 2013
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)