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Protein

Eukaryotic translation initiation factor 6

Gene

TIF6

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotation
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:TIF6UniRule annotation
ORF Names:THITE_2079729Imported
OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
Taxonomic identifieri578455 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
Proteomesi
  • UP000008181 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174Phosphoserine; by CK1UniRule annotation1
Modified residuei175Phosphoserine; by CK1UniRule annotation1

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi578455.XP_003655198.1

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
KOiK03264
OrthoDBiEOG092C4BDP

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

G2RAD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRAQFENS NEVGVFATLT NSYALVAIGA SENFYSVFEA ELQDVIPICR
60 70 80 90 100
TTIAGTRIIG RLTAGNRKGL LVPTSTTDQE LQHLRNSLPD EIRIQRIEER
110 120 130 140 150
LSALGNVIVT NDHTALIHPD LERETEEIVA DVLGVEVFRQ TVADHVLVGS
160 170 180 190 200
YMALSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVIGGGMVVN
210 220 230 240
DWMAVTGLDT TAPELSVIES VFRLGEGAAP GNINTSMKDT IVESFY
Length:246
Mass (Da):26,533
Last modified:November 16, 2011 - v1
Checksum:i83D5F795D791FDA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003012 Genomic DNA Translation: AEO68862.1
RefSeqiXP_003655198.1, XM_003655150.1

Genome annotation databases

EnsemblFungiiAEO68862; AEO68862; THITE_2079729
GeneIDi11524388
KEGGittt:THITE_2079729

Similar proteinsi

Entry informationi

Entry nameiG2RAD0_THITE
AccessioniPrimary (citable) accession number: G2RAD0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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