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Protein

DNA ligase

Gene

THITE_43396

Organism
Thielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:THITE_43396Imported
OrganismiThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)Imported
Taxonomic identifieri578455 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThielavia
ProteomesiUP000008181 Componenti: Chromosome 4

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 2 hits.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2R901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAPEPEAP KARAAPSKPQ SSRNKEPEPV PAVKTEAEED TPESASEVEE
60 70 80 90 100
EELQDEEEKP EVAAKARQTV QASLNSDVKH PYPDWKAGEP VPYAALCKTF
110 120 130 140 150
SLIELTTKRL EILAHCSLFL RQVMRLTPDD LLPTVLLMVN KLAPDYAGIE
160 170 180 190 200
LGIGESLIMK AIGETTGRSL AVIKQDQKEI GDLGLVAVKS RSTQPTMFKP
210 220 230 240 250
KPLTVRGVHK GLMAIATVTG NGAQGRKVDG IKKLLSAADA NSTGKVDITK
260 270 280 290 300
DKGGPSEAKY IIRFLEGKLR LGLAEKTVIV ALAQAVVAHE AARKGKVPST
310 320 330 340 350
SDIEKGESIL KAVYSELPSY DVIIPAMVEH GILNLKEHCK LRPGVPLKPM
360 370 380 390 400
LAKPTKAITE VLDRFEGQTF TCEYKYDGER AQIHYVAKDT DEELSQSASG
410 420 430 440 450
ASKEVGRGVA AIFSRNSEDL SKKYPDVLAK LPTWVKEDTK SFVLDCESVA
460 470 480 490 500
WDVKEKKVLP FQQLMTRKKK DVKVEDVKVK VCVFAFDLLY LNGKPVVEKP
510 520 530 540 550
LRERRELLHQ AFQPVEGEFA FATFMNGQEL DEIQSFLDES VKASCEGLMV
560 570 580 590 600
KMLDGEESGY EPSKRSRNWL KIKKDYLSGV GDSLDLVVLG AYYGKGKRTS
610 620 630 640 650
VYGAFLLACY NPGTDTYETV CNIGTGFSEA VLEELHDSLS QIVIDRPKPF
660 670 680 690 700
YSHSSVGQHQ PDVWFEPRYV WEVRTADLTL SPRYKAGMKE GVDPSGEKGI
710 720 730 740
SLRFPRFIKV RDDKKPDEAT TSRQVAEMYR KQESVTKSKG PAVDDDFEY
Length:749
Mass (Da):82,983
Last modified:November 15, 2011 - v1
Checksum:iE1D5F1CA2C0866C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003012 Genomic DNA. Translation: AEO69451.1.
RefSeqiXP_003655787.1. XM_003655739.1.

Genome annotation databases

GeneIDi11520168.
KEGGittt:THITE_43396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003012 Genomic DNA. Translation: AEO69451.1.
RefSeqiXP_003655787.1. XM_003655739.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11520168.
KEGGittt:THITE_43396.

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 2 hits.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 38088 / NRRL 8126Imported.

Entry informationi

Entry nameiG2R901_THITE
AccessioniPrimary (citable) accession number: G2R901
Entry historyi
Integrated into UniProtKB/TrEMBL: November 15, 2011
Last sequence update: November 15, 2011
Last modified: January 6, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.