ID   G2QET1_THET4            Unreviewed;       409 AA.
AC   G2QET1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Glycoside hydrolase family 33 protein {ECO:0000313|EMBL:AEO58960.1};
GN   ORFNames=MYCTH_2306764 {ECO:0000313|EMBL:AEO58960.1};
OS   Thermothelomyces thermophilus (strain ATCC 42464 / BCRC 31852 / DSM 1799)
OS   (Sporotrichum thermophile).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermothelomyces.
OX   NCBI_TaxID=573729 {ECO:0000313|EMBL:AEO58960.1, ECO:0000313|Proteomes:UP000007322};
RN   [1] {ECO:0000313|EMBL:AEO58960.1, ECO:0000313|Proteomes:UP000007322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42464 / BCRC 31852 / DSM 1799
RC   {ECO:0000313|Proteomes:UP000007322};
RX   PubMed=21964414; DOI=10.1038/nbt.1976;
RA   Berka R.M., Grigoriev I.V., Otillar R., Salamov A., Grimwood J., Reid I.,
RA   Ishmael N., John T., Darmond C., Moisan M.-C., Henrissat B., Coutinho P.M.,
RA   Lombard V., Natvig D.O., Lindquist E., Schmutz J., Lucas S., Harris P.,
RA   Powlowski J., Bellemare A., Taylor D., Butler G., de Vries R.P.,
RA   Allijn I.E., van den Brink J., Ushinsky S., Storms R., Powell A.J.,
RA   Paulsen I.T., Elbourne L.D.H., Baker S.E., Magnuson J., LaBoissiere S.,
RA   Clutterbuck A.J., Martinez D., Wogulis M., de Leon A.L., Rey M.W.,
RA   Tsang A.;
RT   "Comparative genomic analysis of the thermophilic biomass-degrading fungi
RT   Myceliophthora thermophila and Thielavia terrestris.";
RL   Nat. Biotechnol. 29:922-927(2011).
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DR   EMBL; CP003005; AEO58960.1; -; Genomic_DNA.
DR   RefSeq; XP_003664205.1; XM_003664157.1.
DR   AlphaFoldDB; G2QET1; -.
DR   STRING; 573729.G2QET1; -.
DR   GeneID; 11513914; -.
DR   KEGG; mtm:MYCTH_2306764; -.
DR   VEuPathDB; FungiDB:MYCTH_2306764; -.
DR   eggNOG; ENOG502QSIT; Eukaryota.
DR   HOGENOM; CLU_024620_1_0_1; -.
DR   InParanoid; G2QET1; -.
DR   OMA; RTIFMNS; -.
DR   OrthoDB; 5482010at2759; -.
DR   Proteomes; UP000007322; Chromosome 4.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AEO58960.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007322};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..409
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003436235"
FT   DOMAIN          70..369
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          243..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  44513 MW;  16C5EF6CC8DEF473 CRC64;
     MRWLQGIALW AALAPLSHAN VPDPAKDATP YHEEFVLFRS ANMASPDKLS SGVGFHSFRI
     PAVVRTNTGR ILAFAEGRRH NNRDYGDINL VYKRTKTTTS HGASFSDWEP LKEVVGAGAG
     TWGNPTPVVD GDTIYLFMSW NGAQYSQNGG DTLPDGSKTK KIDSTWEGRR HLYLSKSTDD
     GATWSEPEDL TETLTPAGRA WDAVGPGIGI RLTTGELVVP AQQRNIIGRG PPGNRTWSVQ
     SLPGAGSEGT IAQTPDGQLY RNDRPGSNSD YRRVARGNLT SFGAFADDTG LPDPGCEGSV
     LLYNLADDKG PARVVFMNSA SKDSRRAMRV RISYDSDAAK FNFGRELGDA PVSGAGYEGG
     YSSMTKTADY KIGALVESDF YNDKGGEKSY RAIIWRRFNL SWILNGPRN
//