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Protein

L-lactate dehydrogenase

Gene

MYCTH_110317

Organism
Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (MYCTH_110317)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei182Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
ORF Names:MYCTH_110317Imported
OrganismiMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)Imported
Taxonomic identifieri573729 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThermothelomyces
Proteomesi
  • UP000007322 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 31HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi573729.XP_003658959.1.

Structurei

3D structure databases

ProteinModelPortaliG2Q4X7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 149Ldh_1_NInterPro annotationAdd BLAST138
Domaini152 – 313Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
InParanoidiG2Q4X7.
KOiK00016.
OrthoDBiEOG092C3G32.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

G2Q4X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQPNAADVK SIKIVIVGAG SVGVTTAYAL LLDRLAADIV LIDIDKNRAM
60 70 80 90 100
GEVMDLSHAA HFAQARVRVG DYEDCAHAAA VIITAGVNQK PGQTRLDLVK
110 120 130 140 150
TNYALFRDVV PRIARHAPDT ILVVATNPVD VLTHAAHHLS GFPLERVIGS
160 170 180 190 200
GTAMDTTRFR HELGKHFGVN PRNVHAMIVG EHGDSQLPVW SLATICGMRL
210 220 230 240 250
HDYCRAARME HDEAALEACA KRTREAAYEI IRRKGKTNYG VASVLVSILQ
260 270 280 290 300
PIVTDSDAIM TVSRVGTYAG IQDVALSMPC KLNRHGAYQD VPLLLSELEE
310
AELRESAQSI KEVLMSLEK
Length:319
Mass (Da):34,694
Last modified:November 16, 2011 - v1
Checksum:i92AFAD238AD90C88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003002 Genomic DNA. Translation: AEO53714.1.
RefSeqiXP_003658959.1. XM_003658911.1.

Genome annotation databases

EnsemblFungiiAEO53714; AEO53714; MYCTH_110317.
GeneIDi11508231.
KEGGimtm:MYCTH_110317.

Similar proteinsi

Entry informationi

Entry nameiG2Q4X7_MYCTT
AccessioniPrimary (citable) accession number: G2Q4X7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 25, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported