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Protein

Histone deacetylase

Gene

MYCTH_62332

Organism
Thielavia heterothallica (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Myceliophthora thermophila)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:MYCTH_62332Imported
OrganismiThielavia heterothallica (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Myceliophthora thermophila)Imported
Taxonomic identifieri573729 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeMyceliophthora
ProteomesiUP000007322 Componenti: Chromosome 1

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG2Q355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiG2Q355.
KOiK11483.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

G2Q355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSAYQYRP PKPNYLPHNI EADDPIVEEY AVPLGKADDR ENAIFFNKMK
60 70 80 90 100
FAAQEYGIVR PKGYRVSYHA TPEMEKHHFG QTHPMKPWRL TLTKSLVTSY
110 120 130 140 150
GMPFAMDNYV TREATYEELN AFHSSDYLDY LSTATPEDQP QDIDNSDKEV
160 170 180 190 200
KYNLGGSDCP LFHGLYNYCS MSAGCSLDAA RKITNNQSDI AIAWGGGLHH
210 220 230 240 250
AKKYEASGFC YINDIVLAIL QLLRIYPRVL YIDIDVHHGD GVEEAFYSTD
260 270 280 290 300
RVMTVSFHKY HPETFFPGTG ALEDNGPKSE HNPGAHHAIN VPLQDGITDE
310 320 330 340 350
QYENLFQSII GPINERYRPS AIALQCGADS LAGDRLGRFN LRVQGHGACV
360 370 380 390 400
RYCKSLGLPM IMFGGGGYTP RNVARAWAYE TSIAIGADTR IPETIPEHAP
410 420 430 440 450
WREHFIHDTL FPTLEQSMNE PRHNRNSDKR LREIVAHVHE QLRFVSHAPS
460 470 480 490
VQSTIIPPDL GPIRDDVEAR LKEESEEKDG GLRKIQEEGL GQEGEF
Length:496
Mass (Da):55,958
Last modified:November 15, 2011 - v1
Checksum:i2F0C1E2F03AF0E69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003002 Genomic DNA. Translation: AEO53518.1.
RefSeqiXP_003658763.1. XM_003658715.1.

Genome annotation databases

GeneIDi11506047.
KEGGimtm:MYCTH_62332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003002 Genomic DNA. Translation: AEO53518.1.
RefSeqiXP_003658763.1. XM_003658715.1.

3D structure databases

ProteinModelPortaliG2Q355.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11506047.
KEGGimtm:MYCTH_62332.

Phylogenomic databases

InParanoidiG2Q355.
KOiK11483.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42464 / BCRC 31852 / DSM 1799Imported.

Entry informationi

Entry nameiG2Q355_THIHA
AccessioniPrimary (citable) accession number: G2Q355
Entry historyi
Integrated into UniProtKB/TrEMBL: November 15, 2011
Last sequence update: November 15, 2011
Last modified: March 3, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.