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Protein

Histone deacetylase

Gene

MYCTH_62332

Organism
Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateUniRule annotation1
Active sitei200Proton acceptorUniRule annotation1
Binding sitei208Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi235Divalent metal cationUniRule annotation1
Metal bindingi237Divalent metal cationUniRule annotation1
Metal bindingi329Divalent metal cationUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:MYCTH_62332Imported
OrganismiMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)Imported
Taxonomic identifieri573729 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeThermothelomyces
Proteomesi
  • UP000007322 Componenti: Chromosome 1

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi573729.XP_003658763.1.

Structurei

3D structure databases

ProteinModelPortaliG2Q355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 383Hist_deacetylInterPro annotationAdd BLAST301

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiG2Q355.
KOiK11483.
OrthoDBiEOG092C1END.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

G2Q355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSAYQYRP PKPNYLPHNI EADDPIVEEY AVPLGKADDR ENAIFFNKMK
60 70 80 90 100
FAAQEYGIVR PKGYRVSYHA TPEMEKHHFG QTHPMKPWRL TLTKSLVTSY
110 120 130 140 150
GMPFAMDNYV TREATYEELN AFHSSDYLDY LSTATPEDQP QDIDNSDKEV
160 170 180 190 200
KYNLGGSDCP LFHGLYNYCS MSAGCSLDAA RKITNNQSDI AIAWGGGLHH
210 220 230 240 250
AKKYEASGFC YINDIVLAIL QLLRIYPRVL YIDIDVHHGD GVEEAFYSTD
260 270 280 290 300
RVMTVSFHKY HPETFFPGTG ALEDNGPKSE HNPGAHHAIN VPLQDGITDE
310 320 330 340 350
QYENLFQSII GPINERYRPS AIALQCGADS LAGDRLGRFN LRVQGHGACV
360 370 380 390 400
RYCKSLGLPM IMFGGGGYTP RNVARAWAYE TSIAIGADTR IPETIPEHAP
410 420 430 440 450
WREHFIHDTL FPTLEQSMNE PRHNRNSDKR LREIVAHVHE QLRFVSHAPS
460 470 480 490
VQSTIIPPDL GPIRDDVEAR LKEESEEKDG GLRKIQEEGL GQEGEF
Length:496
Mass (Da):55,958
Last modified:November 16, 2011 - v1
Checksum:i2F0C1E2F03AF0E69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003002 Genomic DNA. Translation: AEO53518.1.
RefSeqiXP_003658763.1. XM_003658715.1.

Genome annotation databases

EnsemblFungiiAEO53518; AEO53518; MYCTH_62332.
GeneIDi11506047.
KEGGimtm:MYCTH_62332.

Similar proteinsi

Entry informationi

Entry nameiG2Q355_MYCTT
AccessioniPrimary (citable) accession number: G2Q355
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 30, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported