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Protein

Site-specific DNA-methyltransferase (adenine-specific)

Gene

Calla_1008

Organism
Caldicellulosiruptor lactoaceticus 6A
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181S-adenosyl-L-methionineUniRule annotation
Binding sitei22 – 221S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei67 – 671S-adenosyl-L-methionineUniRule annotation
Binding sitei202 – 2021S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

BioCyciCLAC632516:GHP3-1031-MONOMER.

Protein family/group databases

REBASEi39731. M.Cla6AORF1008P.

Names & Taxonomyi

Protein namesi
Recommended name:
Site-specific DNA-methyltransferase (adenine-specific)UniRule annotation (EC:2.1.1.72UniRule annotation)
Gene namesi
ORF Names:Calla_1008Imported
OrganismiCaldicellulosiruptor lactoaceticus 6AImported
Taxonomic identifieri632516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000009257: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.UniRule annotation

Phylogenomic databases

KOiK06223.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2PVD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTQITFFRQ KVVPIVKWAG GKRQIIKSLL EKLPSNFSTY YEPFLGGGAL
60 70 80 90 100
LIELYNRGIL KNAVVSDINL ELINLYTAIR NCPDEVVYYI KNLDFKNTED
110 120 130 140 150
DYYKARELYN SIKIKSLNTI ERENLLKAVL LLYLNRHCYN GLYRVNSKGE
160 170 180 190 200
FNVPFGRYKN PKLPSREEIF AFSEMLQSVE ILHADFEEAV KKASEFDFVY
210 220 230 240 250
FDPPYMPVSK TANFTDYTVA GFTKEEQVRL KNVCDNLSKK GCFVMISNSD
260 270 280 290
SEFIRELYKS YNLEVIETKR LINSSAGKRT GHKEVIITNY
Length:290
Mass (Da):33,707
Last modified:November 16, 2011 - v1
Checksum:i6B0F57423D1A0D42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003001 Genomic DNA. Translation: AEM73644.1.
RefSeqiWP_014042416.1. NC_015949.1.
YP_004798621.1. NC_015949.1.

Genome annotation databases

EnsemblBacteriaiAEM73644; AEM73644; Calla_1008.
GeneIDi11105039.
KEGGiclc:Calla_1008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003001 Genomic DNA. Translation: AEM73644.1.
RefSeqiWP_014042416.1. NC_015949.1.
YP_004798621.1. NC_015949.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi39731. M.Cla6AORF1008P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEM73644; AEM73644; Calla_1008.
GeneIDi11105039.
KEGGiclc:Calla_1008.

Phylogenomic databases

KOiK06223.

Enzyme and pathway databases

BioCyciCLAC632516:GHP3-1031-MONOMER.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Caldicellulosiruptor lactoaceticus 6A."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Blumer-Schuette S.E., Kelly R.M., Woyke T.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 6AImported.

Entry informationi

Entry nameiG2PVD2_9FIRM
AccessioniPrimary (citable) accession number: G2PVD2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.