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G2PV15 (G2PV15_9FIRM) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length809 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
G2PV15 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: FC84C7806ECDB157

FASTA80991,657
        10         20         30         40         50         60 
MEELDFRIIP VEIQEEMKRS YIDYAMSVIV SRALPDVRDG LKPVHRRILY AMNEIGLTPD 

        70         80         90        100        110        120 
KPYRKSATVV GHVLAKYHPH GDAAVYESLV RMAQDFSMRH PLVDGHGNFG SVDGDPPAAM 

       130        140        150        160        170        180 
RYTEARMSRI ALEMLRDIEK ETVDFMPNFD ESAKEPKVLP SRFPNLLVNG SQGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLAEV IDAIVYLLDN ENATLDDIMK IIKGPDFPTG GYIIGKKGIK DAYATGKGKI 

       250        260        270        280        290        300 
IVRAKTTIEQ TSKGRQRIIV TELPYMVNKA RLIEKIAELV HEKKIDGISD IRDESDKEGL 

       310        320        330        340        350        360 
RIVIEIKKDA DANVVLKQLY KNTQLQDSFG IIMLALVDNQ PKVLTLMDML NLYIEHQKEV 

       370        380        390        400        410        420 
IVRRTRYDLR KAEERAHILE GLKKALDHID EIISIIRSSK TVNEAKERLI SRFQFTEAQA 

       430        440        450        460        470        480 
QAILDMRLQR LTGLERQKIE EELAELIRMI EYYKNVLASD AMVKEIIKKE ILEIKEKYKD 

       490        500        510        520        530        540 
ERRTKIIQDE HEDFEEEELI QEQETVITLT HFGYIKRLPL DTYKSQKRGG RGITGISTRE 

       550        560        570        580        590        600 
EDFVEDVFVT TTHHYILFFT DKGRVFRLRA YEVPEGSRQA KGTAIVNLIQ IGKDEKITAT 

       610        620        630        640        650        660 
MAVKDFKEGY LMMCTKNGTI KKVLLSEFEN TTKAGKKAIT LADDDSLVDV KLTSGNDEIV 

       670        680        690        700        710        720 
LVSSSGYCVV FNENDVRVMG RSAQGVKGMT LESGDFIVGM EKANDGKYLL CVTENGFGKR 

       730        740        750        760        770        780 
SEIEEYRKTK RGAKGVLTYK VTDKTGKIVD IKMVNDDDEI MICSTEGIFI RLEVSQVPVQ 

       790        800 
GRNTQGVKLM RIDGDSIKVS SIARIKAEE

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References

[1]"Complete sequence of Caldicellulosiruptor lactoaceticus 6A."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Blumer-Schuette S.E., Kelly R.M., Woyke T.
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 6A EMBL AEM72706.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003001 Genomic DNA. Translation: AEM72706.1.
RefSeqYP_004797683.1. NC_015949.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEM72706; AEM72706; Calla_0007.
GeneID11106560.
KEGGclc:Calla_0007.

Phylogenomic databases

KOK02469.

Enzyme and pathway databases

BioCycCLAC632516:GHP3-7-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG2PV15_9FIRM
AccessionPrimary (citable) accession number: G2PV15
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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