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Protein

Thymidine kinase

Gene

tdk

Organism
Muricauda ruestringensis (strain DSM 13258 / LMG 19739 / B1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMRUE886377:GI6V-1263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Murru_1248Imported
OrganismiMuricauda ruestringensis (strain DSM 13258 / LMG 19739 / B1)Imported
Taxonomic identifieri886377 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeMuricauda
ProteomesiUP000008908 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi886377.Murru_1248.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiVTKVHAI.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

G2PNV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLENTVNPK EQFGWIEVIC GSMFSGKTEE LIRRLKRAQF AKQKVEIFKP
60 70 80 90 100
IVDRRYHEEM VVSHDSNEIR STPVPAAANI RLLADDCEVV GIDEAQFFDD
110 120 130 140 150
EIVTVCNDLA NRGVRVVVAG LDMDFKGNPF GPMPALMATA EYVTKVHAVC
160 170 180 190 200
TRTGNLANYS FRKSLNDNLV LLGETEEYEP LSRAAFYKAM LREKIKEMDV
210
ESEEVGTKKK KSNE
Length:214
Mass (Da):24,232
Last modified:November 16, 2011 - v1
Checksum:i49116301C59F0B59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002999 Genomic DNA. Translation: AEM70291.1.
RefSeqiWP_014032572.1. NC_015945.1.

Genome annotation databases

EnsemblBacteriaiAEM70291; AEM70291; Murru_1248.
KEGGimrs:Murru_1248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002999 Genomic DNA. Translation: AEM70291.1.
RefSeqiWP_014032572.1. NC_015945.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi886377.Murru_1248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEM70291; AEM70291; Murru_1248.
KEGGimrs:Murru_1248.

Phylogenomic databases

KOiK00857.
OMAiVTKVHAI.

Enzyme and pathway databases

BioCyciMRUE886377:GI6V-1263-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13258 / LMG 19739 / B1Imported.

Entry informationi

Entry nameiG2PNV6_MURRD
AccessioniPrimary (citable) accession number: G2PNV6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 22, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.