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Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces violaceusniger Tu 4113
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei208ATPUniRule annotation1
Active sitei210N6-AMP-lysine intermediateUniRule annotation1
Binding sitei215ATPUniRule annotation1
Binding sitei230ATPUniRule annotation1
Binding sitei259ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei377ATPUniRule annotation1
Binding sitei383ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
ORF Names:Strvi_0343Imported
OrganismiStreptomyces violaceusniger Tu 4113Imported
Taxonomic identifieri653045 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000008703 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi653045.Strvi_0343

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini299 – 417DNA_LIGASE_A3InterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
KOiK10747
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

G2PB79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLADVALTS RQVAATSARS EKIAALARLF RRTEPAEAAV VITYLAGKLP
60 70 80 90 100
QRRTGVGWST LRHRQEPAAE PTLAVLDVDE ALTRVAAVSG TGATAARKRL
110 120 130 140 150
VGELLAAATK EEQGFLLGLI GGELRQGALE GLAVEGLAQA VGAPAAEVRR
160 170 180 190 200
AVMVGGSLGT VAEALLARGP EALAGFRLEV GRPVLPMLAQ SAKDLDEAID
210 220 230 240 250
RLGPCAVEEK LDGIRVQVHR DGEDVRIYTR TLDEITDRLP EVVTAARELA
260 270 280 290 300
VDRAILDGEV ILLDGEGRPR PFQETSARVG SRLDVAGASA ALPLSPVFFD
310 320 330 340 350
LLVVDDRDLL DLPARERHAE LARIAPGPRR VRRLVTDDPA DPETRRAARE
360 370 380 390 400
FAADVLARGH EGVLVKALEA PYGAGRRGAS WLKVKPVHTL DLVVLAAEWG
410 420 430 440 450
HGRRTGKLSN LHLGARAADG TYLMLGKTFK GLTDAMLEWQ TQALLGIAVS
460 470 480 490 500
DDGWVVRVRP ELVVEVAFDG LQRSSRYPAG VTLRFARVLR YREDKPADQA
510
DTVEAVLALR GE
Length:512
Mass (Da):54,947
Last modified:November 16, 2011 - v1
Checksum:iED101FB05D7D9559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002994 Genomic DNA Translation: AEM80131.1
RefSeqiWP_014053655.1, NC_015957.1

Genome annotation databases

EnsemblBacteriaiAEM80131; AEM80131; Strvi_0343
GeneIDi32487816
KEGGisvl:Strvi_0343

Similar proteinsi

Entry informationi

Entry nameiG2PB79_STRVO
AccessioniPrimary (citable) accession number: G2PB79
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health