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G2PB79

- G2PB79_STRVO

UniProt

G2PB79 - G2PB79_STRVO

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Protein

Probable DNA ligase

Gene
lig, Strvi_0343
Organism
Streptomyces violaceusniger Tu 4113
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATP By similarityUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei215 – 2151ATP By similarityUniRule annotation
Binding sitei230 – 2301ATP By similarityUniRule annotation
Binding sitei259 – 2591ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei377 – 3771ATP By similarityUniRule annotation
Binding sitei383 – 3831ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSVIO653045:GHK6-96-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
ORF Names:Strvi_0343Imported
OrganismiStreptomyces violaceusniger Tu 4113Imported
Taxonomic identifieri653045 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000008703: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2PB79-1 [UniParc]FASTAAdd to Basket

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MLLADVALTS RQVAATSARS EKIAALARLF RRTEPAEAAV VITYLAGKLP    50
QRRTGVGWST LRHRQEPAAE PTLAVLDVDE ALTRVAAVSG TGATAARKRL 100
VGELLAAATK EEQGFLLGLI GGELRQGALE GLAVEGLAQA VGAPAAEVRR 150
AVMVGGSLGT VAEALLARGP EALAGFRLEV GRPVLPMLAQ SAKDLDEAID 200
RLGPCAVEEK LDGIRVQVHR DGEDVRIYTR TLDEITDRLP EVVTAARELA 250
VDRAILDGEV ILLDGEGRPR PFQETSARVG SRLDVAGASA ALPLSPVFFD 300
LLVVDDRDLL DLPARERHAE LARIAPGPRR VRRLVTDDPA DPETRRAARE 350
FAADVLARGH EGVLVKALEA PYGAGRRGAS WLKVKPVHTL DLVVLAAEWG 400
HGRRTGKLSN LHLGARAADG TYLMLGKTFK GLTDAMLEWQ TQALLGIAVS 450
DDGWVVRVRP ELVVEVAFDG LQRSSRYPAG VTLRFARVLR YREDKPADQA 500
DTVEAVLALR GE 512
Length:512
Mass (Da):54,947
Last modified:November 16, 2011 - v1
Checksum:iED101FB05D7D9559
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002994 Genomic DNA. Translation: AEM80131.1.
RefSeqiWP_014053655.1. NC_015957.1.
YP_004810411.1. NC_015957.1.

Genome annotation databases

EnsemblBacteriaiAEM80131; AEM80131; Strvi_0343.
GeneIDi11088841.
KEGGisvl:Strvi_0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002994 Genomic DNA. Translation: AEM80131.1 .
RefSeqi WP_014053655.1. NC_015957.1.
YP_004810411.1. NC_015957.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEM80131 ; AEM80131 ; Strvi_0343 .
GeneIDi 11088841.
KEGGi svl:Strvi_0343.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci SVIO653045:GHK6-96-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces violaceusniger Tu 4113."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ivanova N., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Hagen A.
    , Katz L., Fiedler H.-P., Keasling J., Fortman J., Woyke T.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Tu 4113Imported.

Entry informationi

Entry nameiG2PB79_STRVO
AccessioniPrimary (citable) accession number: G2PB79
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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