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G2NRI0

- G2NRI0_9ACTO

UniProt

G2NRI0 - G2NRI0_9ACTO

Protein

Xylose isomerase

Gene

xylA

Organism
Streptomyces sp. SirexAA-E
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561UniRule annotation
    Active sitei59 – 591UniRule annotation
    Metal bindingi183 – 1831Magnesium 1UniRule annotation
    Metal bindingi219 – 2191Magnesium 1UniRule annotation
    Metal bindingi219 – 2191Magnesium 2UniRule annotation
    Metal bindingi222 – 2221Magnesium 2UniRule annotation
    Metal bindingi247 – 2471Magnesium 1UniRule annotation
    Metal bindingi257 – 2571Magnesium 2UniRule annotation
    Metal bindingi259 – 2591Magnesium 2UniRule annotation
    Metal bindingi289 – 2891Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSSP862751:GHMW-5312-MONOMER.
    SSP862751:GHMW-5911-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    ORF Names:SACTE_5230Imported, SACTE_5828Imported
    OrganismiStreptomyces sp. SirexAA-EImported
    Taxonomic identifieri862751 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001397: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    KOiK01805.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2NRI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPERFTPTPE DKFTFGLWTV GWRGNDPFGE PTRPVLDPVE SVERLAELGA    50
    HGVTFHDDDL IPFGSDDRER ARLVGRFREA LERTGLKVPM ATTNLFTHPV 100
    FKDGGFTSND RDVRRFALRK VIRNIDLAVE LGAQTYVAWG GREGAESGAA 150
    KDVRSALDRM KEAFDLLGDY VTEQGYDLRF AIEPKPNEPR GDILLPTIGH 200
    ALAFIERLER PELVGVNPET GHEQMAGLNF PHGIAQALWA GKLFHIDLNG 250
    QSGIKYDQDF RFGAGDLRQA FWLVDLLETA GWDGSRHFDF KPVRTDGIDG 300
    VWESAKNCMR NYLILKERAA AFRADPAVQE ALTASRLDEL ARPTADDGLK 350
    ALLADRTAYE DFDATAAAER SMAFEALDQL AMDHLLNVR 389
    Length:389
    Mass (Da):43,444
    Last modified:November 16, 2011 - v1
    Checksum:i4AD0522DB812E433
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002993 Genomic DNA. Translation: AEN13046.1.
    CP002993 Genomic DNA. Translation: AEN13613.1.
    RefSeqiYP_004805586.1. NC_015953.1.
    YP_004806153.1. NC_015953.1.

    Genome annotation databases

    EnsemblBacteriaiAEN13046; AEN13046; SACTE_5230.
    AEN13613; AEN13613; SACTE_5828.
    GeneIDi11098352.
    11099842.
    KEGGissx:SACTE_5230.
    ssx:SACTE_5828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002993 Genomic DNA. Translation: AEN13046.1 .
    CP002993 Genomic DNA. Translation: AEN13613.1 .
    RefSeqi YP_004805586.1. NC_015953.1.
    YP_004806153.1. NC_015953.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN13046 ; AEN13046 ; SACTE_5230 .
    AEN13613 ; AEN13613 ; SACTE_5828 .
    GeneIDi 11098352.
    11099842.
    KEGGi ssx:SACTE_5230.
    ssx:SACTE_5828.

    Phylogenomic databases

    KOi K01805.

    Enzyme and pathway databases

    BioCyci SSP862751:GHMW-5312-MONOMER.
    SSP862751:GHMW-5911-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SirexAA-EImported.
    2. "Biochemical Properties and Atomic Resolution Structure of a Proteolytically Processed beta-Mannanase from Cellulolytic Streptomyces sp. SirexAA-E."
      Takasuka T.E., Acheson J.F., Bianchetti C.M., Prom B.M., Bergeman L.F., Book A.J., Currie C.R., Fox B.G.
      PLoS ONE 9:E94166-E94166(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SirexAA-EImported.

    Entry informationi

    Entry nameiG2NRI0_9ACTO
    AccessioniPrimary (citable) accession number: G2NRI0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3