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Protein

Xylose isomerase

Gene

xylA

Organism
Streptomyces sp. (strain SirexAA-E / ActE)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561UniRule annotation
Active sitei59 – 591UniRule annotation
Metal bindingi183 – 1831Magnesium 1UniRule annotation
Metal bindingi219 – 2191Magnesium 1UniRule annotation
Metal bindingi219 – 2191Magnesium 2UniRule annotation
Metal bindingi222 – 2221Magnesium 2UniRule annotation
Metal bindingi247 – 2471Magnesium 1UniRule annotation
Metal bindingi257 – 2571Magnesium 2UniRule annotation
Metal bindingi259 – 2591Magnesium 2UniRule annotation
Metal bindingi289 – 2891Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSSP862751:GHMW-5312-MONOMER.
SSP862751:GHMW-5911-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
ORF Names:SACTE_5230Imported, SACTE_5828Imported
OrganismiStreptomyces sp. (strain SirexAA-E / ActE)Imported
Taxonomic identifieri862751 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
ProteomesiUP000001397 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi862751.SACTE_5828.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

KOiK01805.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2NRI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERFTPTPE DKFTFGLWTV GWRGNDPFGE PTRPVLDPVE SVERLAELGA
60 70 80 90 100
HGVTFHDDDL IPFGSDDRER ARLVGRFREA LERTGLKVPM ATTNLFTHPV
110 120 130 140 150
FKDGGFTSND RDVRRFALRK VIRNIDLAVE LGAQTYVAWG GREGAESGAA
160 170 180 190 200
KDVRSALDRM KEAFDLLGDY VTEQGYDLRF AIEPKPNEPR GDILLPTIGH
210 220 230 240 250
ALAFIERLER PELVGVNPET GHEQMAGLNF PHGIAQALWA GKLFHIDLNG
260 270 280 290 300
QSGIKYDQDF RFGAGDLRQA FWLVDLLETA GWDGSRHFDF KPVRTDGIDG
310 320 330 340 350
VWESAKNCMR NYLILKERAA AFRADPAVQE ALTASRLDEL ARPTADDGLK
360 370 380
ALLADRTAYE DFDATAAAER SMAFEALDQL AMDHLLNVR
Length:389
Mass (Da):43,444
Last modified:November 16, 2011 - v1
Checksum:i4AD0522DB812E433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002993 Genomic DNA. Translation: AEN13046.1.
CP002993 Genomic DNA. Translation: AEN13613.1.
RefSeqiWP_014048996.1. NC_015953.1.
YP_004805586.1. NC_015953.1.
YP_004806153.1. NC_015953.1.

Genome annotation databases

EnsemblBacteriaiAEN13046; AEN13046; SACTE_5230.
AEN13613; AEN13613; SACTE_5828.
KEGGissx:SACTE_5230.
ssx:SACTE_5828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002993 Genomic DNA. Translation: AEN13046.1.
CP002993 Genomic DNA. Translation: AEN13613.1.
RefSeqiWP_014048996.1. NC_015953.1.
YP_004805586.1. NC_015953.1.
YP_004806153.1. NC_015953.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi862751.SACTE_5828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEN13046; AEN13046; SACTE_5230.
AEN13613; AEN13613; SACTE_5828.
KEGGissx:SACTE_5230.
ssx:SACTE_5828.

Phylogenomic databases

KOiK01805.

Enzyme and pathway databases

BioCyciSSP862751:GHMW-5312-MONOMER.
SSP862751:GHMW-5911-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SirexAA-EImported and SirexAA-E / ActEImported.
  2. "Biochemical Properties and Atomic Resolution Structure of a Proteolytically Processed beta-Mannanase from Cellulolytic Streptomyces sp. SirexAA-E."
    Takasuka T.E., Acheson J.F., Bianchetti C.M., Prom B.M., Bergeman L.F., Book A.J., Currie C.R., Fox B.G.
    PLoS ONE 9:E94166-E94166(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SirexAA-EImported.

Entry informationi

Entry nameiG2NRI0_STREK
AccessioniPrimary (citable) accession number: G2NRI0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 24, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.