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G2NNB6

- G2NNB6_9ACTO

UniProt

G2NNB6 - G2NNB6_9ACTO

Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces sp. SirexAA-E
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei208 – 2081ATPUniRule annotation
    Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
    Binding sitei215 – 2151ATPUniRule annotation
    Binding sitei230 – 2301ATPUniRule annotation
    Binding sitei259 – 2591ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei377 – 3771ATPUniRule annotation
    Binding sitei383 – 3831ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP862751:GHMW-611-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    ORF Names:SACTE_0610Imported
    OrganismiStreptomyces sp. SirexAA-EImported
    Taxonomic identifieri862751 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000001397: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK01971.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2NNB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLARLAHVS LEVAATSARN RKVALLAGLF RETGPDDVPT VIPYLAGRLP    50
    QGRLGIGWSA LSDPPRPADT PVLTVAEAHA ELTAVGALSG PGSQAARKER 100
    LRRLFAAATA DEQHFLRGLL TGELRQGALE ALAADALAAA TGAPPADVRR 150
    AVMLAGSLQS VARALLADGP EALAAFRLTV GRPVLPMLAH TAGSVTEAVD 200
    KLGPCAVEEK LDGIRVQVHR DGAGVRIYTR TLDDITDRLP EPATAVARFP 250
    GERFVLDGEV IALGPDGRPR PFQETAARVG SRRDVATAAA AVPVVAVFFD 300
    VLALDGRELI DLPFTERHTA LDTLVPEPMR VRRVTVTDPR DPAARRAAEE 350
    FFEAALGRGH EGVVAKGASA PYSAGRRGAS WLKVKPVHTL DLVVLAAEWG 400
    HGRRTGKLSN LHLGARRPDG TFAMLGKTFK GLTDTMLAWQ TERLLELSTG 450
    DDGHVVTVRP ELVVEIAYDG LQDSTRYPAG VTLRFARVLG YREDKPPEEA 500
    DTVDTVLSRR A 511
    Length:511
    Mass (Da):54,502
    Last modified:November 16, 2011 - v1
    Checksum:i4362F0B5505FDDB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002993 Genomic DNA. Translation: AEN08547.1.
    RefSeqiYP_004801087.1. NC_015953.1.

    Genome annotation databases

    EnsemblBacteriaiAEN08547; AEN08547; SACTE_0610.
    GeneIDi11102866.
    KEGGissx:SACTE_0610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002993 Genomic DNA. Translation: AEN08547.1 .
    RefSeqi YP_004801087.1. NC_015953.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN08547 ; AEN08547 ; SACTE_0610 .
    GeneIDi 11102866.
    KEGGi ssx:SACTE_0610.

    Phylogenomic databases

    KOi K01971.

    Enzyme and pathway databases

    BioCyci SSP862751:GHMW-611-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical Properties and Atomic Resolution Structure of a Proteolytically Processed beta-Mannanase from Cellulolytic Streptomyces sp. SirexAA-E."
      Takasuka T.E., Acheson J.F., Bianchetti C.M., Prom B.M., Bergeman L.F., Book A.J., Currie C.R., Fox B.G.
      PLoS ONE 9:E94166-E94166(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SirexAA-EImported.

    Entry informationi

    Entry nameiG2NNB6_9ACTO
    AccessioniPrimary (citable) accession number: G2NNB6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3