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Protein

Alanine racemase

Gene

SACTE_4016

Organism
Streptomyces sp. (strain SirexAA-E / ActE)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (SACTE_4016)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei319Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSSP862751:G1GPM-4079-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:SACTE_4016Imported
OrganismiStreptomyces sp. (strain SirexAA-E / ActE)Imported
Taxonomic identifieri862751 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001397 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi862751.SACTE_4016

Structurei

3D structure databases

ProteinModelPortaliG2NF88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 377Ala_racemase_CInterPro annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 28Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.102 hits
3.20.20.101 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

G2NF88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNETASLRAR AEIDLAALRA NVRVLRARAS GAQLMAVVKS DAYGHGALPC
60 70 80 90 100
ARAALEAGAT WLGTATPQEA LALREAGVGG RVMCWLWTPG GPWREAIEAD
110 120 130 140 150
IDVSVSGMWA LREVVEAATA AGRPARVQLK ADTGLGRNGC QPADWPELVS
160 170 180 190 200
AARGAEEAGT LRVTGLWSHF ACADEPGHPS IAAQLTAFRD MVAYAEKEGV
210 220 230 240 250
RPEVRHIANS PATLTLPESH FDLVRTGIAM YGLSPSPALG TPADFGLRPV
260 270 280 290 300
MTLSASVALV KEVPPGHGIS YGHHYTTSAE TTLALVPLGY ADGIPRHASG
310 320 330 340 350
RGPVLIDGAV RTVAGRVAMD QFVVDLGGDT PRPGARAVLF GPGDQGEPGA
360 370 380
EDWAVAADTI GYEIVTRISG RVPRVHLHAS PERG
Length:384
Mass (Da):40,150
Last modified:November 16, 2011 - v1
Checksum:i9D4E024DBF3DEE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002993 Genomic DNA Translation: AEN11859.1
RefSeqiWP_014047820.1, NC_015953.1

Genome annotation databases

EnsemblBacteriaiAEN11859; AEN11859; SACTE_4016
KEGGissx:SACTE_4016
PATRICifig|862751.12.peg.4167

Similar proteinsi

Entry informationi

Entry nameiG2NF88_STREK
AccessioniPrimary (citable) accession number: G2NF88
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported