UniProtKB - G2NEY8 (G2NEY8_STREK)
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Protein
Chromosomal replication initiator protein DnaA
Gene
dnaA
Organism
Streptomyces sp. (strain SirexAA-E / ActE)
Status
Functioni
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 278 – 285 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA replication origin binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication initiation Source: UniProtKB-UniRule
- regulation of DNA replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingUniRule annotationSAAS annotation |
Biological process | DNA replicationUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosomal replication initiator protein DnaAUniRule annotation |
Gene namesi | Name:dnaAUniRule annotation ORF Names:SACTE_3308Imported |
Organismi | Streptomyces sp. (strain SirexAA-E / ActE)Imported |
Taxonomic identifieri | 862751 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotationSAAS annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 270 – 398 | AAAInterPro annotationAdd BLAST | 129 | |
Domaini | 484 – 553 | Bac_DnaA_CInterPro annotationAdd BLAST | 70 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 553 – 573 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | ENOG4105CI4. Bacteria. COG0593. LUCA. |
KOi | K02313. |
OrthoDBi | POG091H02FF. |
Family and domain databases
CDDi | cd06571. Bac_DnaA_C. 1 hit. |
Gene3Di | 1.10.1750.10. 1 hit. 3.30.300.180. 1 hit. |
HAMAPi | MF_00377. DnaA_bact. 1 hit. |
InterProi | View protein in InterPro IPR003593. AAA+_ATPase. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013317. DnaA. IPR013159. DnaA_C. IPR038454. DnaA_N_sf. IPR027417. P-loop_NTPase. IPR010921. Trp_repressor/repl_initiator. |
PANTHERi | PTHR30050:SF2. PTHR30050:SF2. 1 hit. |
Pfami | View protein in Pfam PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. |
PRINTSi | PR00051. DNAA. |
SMARTi | View protein in SMART SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. |
SUPFAMi | SSF48295. SSF48295. 1 hit. SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR00362. DnaA. 1 hit. |
PROSITEi | View protein in PROSITE PS01008. DNAA. 1 hit. |
i Sequence
Sequence statusi: Complete.
G2NEY8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDQLLGEGQ QGIEPKDKQW IERCQPLALV ADTALLAVPN EWGKRVLEGR
60 70 80 90 100
LAPLISETLT RECGRPIRIA ITVDDSANEP PTPPAPPMHQ QHQSQGQQPH
110 120 130 140 150
HYQGPQRDEQ PRNDVYDGYG HRPSDDGMPT ARPAYPDYQQ QRPGAWPRSQ
160 170 180 190 200
EDLSWQPRHG GYQDMDPYAS TRPQQPQHDY RPQPPERQGY EPQRDGRDRH
210 220 230 240 250
DMQEQQPPHH QGGHGRAGGP PGSQSAPAPG TNEPHARLNP KYLFDTFVIG
260 270 280 290 300
ASNRFAHAAA VAVAEAPAKA YNPLFIYGES GLGKTHLLHA IGHYARSLYP
310 320 330 340 350
GTRVRYVSSE EFTNEFINSI RDGKGDTFRK RYRDVDILLV DDIQFLASKE
360 370 380 390 400
STQEEFFHTF NTLHNANKQI VLSSDRPPKQ LVTLEDRLRN RFEWGLTTDV
410 420 430 440 450
QPPELETRIA ILRKKAVQEQ LNAPPEVLEF IASRISRNIR ELEGALIRVT
460 470 480 490 500
AFASLNRQPV DLGLTEIVLK DLIPGGEDTA PEITAPAIMA STADYFGLTV
510 520 530 540 550
EDLCGSSRSR VLVTARQIAM YLCRELTDLS LPKIGAQFGG RDHTTVMHAD
560 570
RKIRALMAER RSIYNQVTEL TNRIKNG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP002993 Genomic DNA. Translation: AEN11174.1. |
Genome annotation databases
EnsemblBacteriai | AEN11174; AEN11174; SACTE_3308. |
KEGGi | ssx:SACTE_3308. |
PATRICi | fig|862751.12.peg.3442. |
Similar proteinsi
Entry informationi
Entry namei | G2NEY8_STREK | |
Accessioni | G2NEY8Primary (citable) accession number: G2NEY8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | March 28, 2018 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |