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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Streptomyces sp. (strain SirexAA-E / ActE)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi278 – 285ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
ORF Names:SACTE_3308Imported
OrganismiStreptomyces sp. (strain SirexAA-E / ActE)Imported
Taxonomic identifieri862751 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001397 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi862751.SACTE_3308.

Structurei

3D structure databases

ProteinModelPortaliG2NEY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 398AAAInterPro annotationAdd BLAST129
Domaini484 – 553Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
KOiK02313.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF2. PTHR30050:SF2. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiView protein in PROSITE
PS01008. DNAA. 1 hit.

Sequencei

Sequence statusi: Complete.

G2NEY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDQLLGEGQ QGIEPKDKQW IERCQPLALV ADTALLAVPN EWGKRVLEGR
60 70 80 90 100
LAPLISETLT RECGRPIRIA ITVDDSANEP PTPPAPPMHQ QHQSQGQQPH
110 120 130 140 150
HYQGPQRDEQ PRNDVYDGYG HRPSDDGMPT ARPAYPDYQQ QRPGAWPRSQ
160 170 180 190 200
EDLSWQPRHG GYQDMDPYAS TRPQQPQHDY RPQPPERQGY EPQRDGRDRH
210 220 230 240 250
DMQEQQPPHH QGGHGRAGGP PGSQSAPAPG TNEPHARLNP KYLFDTFVIG
260 270 280 290 300
ASNRFAHAAA VAVAEAPAKA YNPLFIYGES GLGKTHLLHA IGHYARSLYP
310 320 330 340 350
GTRVRYVSSE EFTNEFINSI RDGKGDTFRK RYRDVDILLV DDIQFLASKE
360 370 380 390 400
STQEEFFHTF NTLHNANKQI VLSSDRPPKQ LVTLEDRLRN RFEWGLTTDV
410 420 430 440 450
QPPELETRIA ILRKKAVQEQ LNAPPEVLEF IASRISRNIR ELEGALIRVT
460 470 480 490 500
AFASLNRQPV DLGLTEIVLK DLIPGGEDTA PEITAPAIMA STADYFGLTV
510 520 530 540 550
EDLCGSSRSR VLVTARQIAM YLCRELTDLS LPKIGAQFGG RDHTTVMHAD
560 570
RKIRALMAER RSIYNQVTEL TNRIKNG
Length:577
Mass (Da):64,857
Last modified:November 16, 2011 - v1
Checksum:i7765D1F621E699E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002993 Genomic DNA. Translation: AEN11174.1.

Genome annotation databases

EnsemblBacteriaiAEN11174; AEN11174; SACTE_3308.
KEGGissx:SACTE_3308.
PATRICifig|862751.12.peg.3442.

Similar proteinsi

Entry informationi

Entry nameiG2NEY8_STREK
AccessioniPrimary (citable) accession number: G2NEY8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 25, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported