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G2N5T8 (G2N5T8_MYCTX) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407

EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:ligB EMBL AEN01529.1
Synonyms:lig HAMAP-Rule MF_00407
ORF Names:MTCTRI2_3125 EMBL AEN01529.1
OrganismMycobacterium tuberculosis CTRI-2 [Complete proteome] EMBL AEN01529.1
Taxonomic identifier707235 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196 HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2111N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2091ATP By similarity HAMAP-Rule MF_00407
Binding site2161ATP By similarity HAMAP-Rule MF_00407
Binding site2311ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site3001ATP By similarity HAMAP-Rule MF_00407
Binding site3721ATP By similarity HAMAP-Rule MF_00407
Binding site3781ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
G2N5T8 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 8D73EB4C08C7149D

FASTA50753,727
        10         20         30         40         50         60 
MLLHDVAITS MDVAATSSRL TKVARIAALL HRAAPDTQLV TIIVSWLSGE LPQRHIGVGW 

        70         80         90        100        110        120 
AALRSLPPPA PQPALTVTGV DATLSKIGTL SGKGSQAQRA ALVAELFSAA TEAEQTFLLR 

       130        140        150        160        170        180 
LLGGELRQGA KGGIMADAVA QAAGLPAATV QRAAMLGGDL AAAAAAGLSG AALDTFTLRV 

       190        200        210        220        230        240 
GRPIGPMLAQ TATSVHDALE RHGGTTIFEA KLDGARVQIH RANDQVRIYT RSLDDVTARL 

       250        260        270        280        290        300 
PEVVEATLAL PVRDLVADGE AIALCPDNRP QRFQVTASRF GRSVDVAAAR ATQPLSVFFF 

       310        320        330        340        350        360 
DILHRDGTDL LEAPTTERLA ALDALVPARH RVDRLITSDP TDAANFLDAT LAAGHEGVMA 

       370        380        390        400        410        420 
KAPAARYLAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRR GKLSNIHLGA RDPATGGFVM 

       430        440        450        460        470        480 
VGKTFKGMTD AMLDWQTTRF HEIAVGPTDG YVVQLRPEQV VEVALDGVQR SSRYPGGLAL 

       490        500 
RFARVVRYRA DKDPAEADTI DAVRALY 

« Hide

References

[1]"The Complete Genome Sequence of Mycobacterium tuberculosis CTRI2."
Shitikov E., Ilina E., Ikryannikova L., Malakhova M., Parfenova T., Afanas'ev M., Kamashev D., Bazaleev N., Ischenko D., Aliper A., Alekseev D., Smirnova T., Chernousova L., Larionova E., Beletsky A., Mardanov A., Ravin N., Skryabin K., Govorun V.
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CTRI-2 EMBL AEN01529.1.
[2]"Comparative Genomic Analysis of Mycobacterium tuberculosis Drug Resistant Strains from Russia."
Ilina E.N., Shitikov E.A., Ikryannikova L.N., Alekseev D.G., Kamashev D.E., Malakhova M.V., Parfenova T.V., Afanas'ev M.V., Ischenko D.S., Bazaleev N.A., Smirnova T.G., Larionova E.E., Chernousova L.N., Beletsky A.V., Mardanov A.V., Ravin N.V., Skryabin K.G., Govorun V.M.
PLoS ONE 8:E56577-E56577(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CTRI-2 EMBL AEN01529.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002992 Genomic DNA. Translation: AEN01529.1.
RefSeqYP_005918150.1. NC_017524.1.

3D structure databases

ProteinModelPortalG2N5T8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEN01529; AEN01529; MTCTRI2_3125.
GeneID12508293.
KEGGmto:MTCTRI2_3125.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01971.

Enzyme and pathway databases

BioCycMTUB707235:GLGU-3124-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG2N5T8_MYCTX
AccessionPrimary (citable) accession number: G2N5T8
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)