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Protein

Xylose isomerase

Gene

xylA

Organism
Thermoanaerobacter wiegelii Rt8.B1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100UniRule annotation1
Active sitei103UniRule annotation1
Metal bindingi231Magnesium 1UniRule annotation1
Metal bindingi267Magnesium 1UniRule annotation1
Metal bindingi267Magnesium 2UniRule annotation1
Metal bindingi270Magnesium 2UniRule annotation1
Metal bindingi295Magnesium 1UniRule annotation1
Metal bindingi306Magnesium 2UniRule annotation1
Metal bindingi308Magnesium 2UniRule annotation1
Metal bindingi338Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.5UniRule annotationSAAS annotation)
Gene namesi
Name:xylAUniRule annotation
ORF Names:Thewi_0220Imported
OrganismiThermoanaerobacter wiegelii Rt8.B1Imported
Taxonomic identifieri697303 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000008276 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi697303.Thewi_0220.

Structurei

3D structure databases

ProteinModelPortaliG2MRX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 284AP_endonuc_2InterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
KOiK01805.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2MRX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYFKNVPQI KYEGPKSNNP YAFKFYNPDE IIDGKPLKEH LRFSVAYWHT
60 70 80 90 100
FTWSGTDPFG APTMQRPWDH LSDPMDIAKA RVEAAFELFE KLDVPFFCFH
110 120 130 140 150
DRDIAPEGET LRETNKNLDT IVVMIKDYLK TSKTKVLWGT ANLFSNPRFV
160 170 180 190 200
HGAATSCNAD VFAYAAAQVK KALEITKELG GQNYVFWGGR EGYETLLNTD
210 220 230 240 250
MELEFDNLAR FLHMAVEYAQ EIGFEGQFLI EPKPKEPTKH QYDFDAASVH
260 270 280 290 300
AFLKKYDLDK YFKLNIEANH ATLAGHDFQH ELRYARINNM LGSIDANMGD
310 320 330 340 350
MLLGWDTDQY PTDIRMTTLA MYEVIKMGGF NKGGLNFDAK VRRASFEPED
360 370 380 390 400
LFLGHIAGMD AFAKGFKVAY KIVKDGVFDR FIEERYKSYR EGIGAEIVNG
410 420 430
KANFKTLEEY ALNNPKIENK SGKQELLESI LNQYLFSE
Length:438
Mass (Da):50,287
Last modified:November 16, 2011 - v1
Checksum:i4AEC61D56B32C645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002991 Genomic DNA. Translation: AEM77724.1.
RefSeqiWP_014062099.1. NC_015958.1.

Genome annotation databases

EnsemblBacteriaiAEM77724; AEM77724; Thewi_0220.
GeneIDi11082441.
KEGGitwi:Thewi_0220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002991 Genomic DNA. Translation: AEM77724.1.
RefSeqiWP_014062099.1. NC_015958.1.

3D structure databases

ProteinModelPortaliG2MRX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi697303.Thewi_0220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEM77724; AEM77724; Thewi_0220.
GeneIDi11082441.
KEGGitwi:Thewi_0220.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
KOiK01805.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG2MRX8_9THEO
AccessioniPrimary (citable) accession number: G2MRX8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.