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G2MRX8

- G2MRX8_9THEO

UniProt

G2MRX8 - G2MRX8_9THEO

Protein

Xylose isomerase

Gene

xylA

Organism
Thermoanaerobacter wiegelii Rt8.B1
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001UniRule annotation
    Active sitei103 – 1031UniRule annotation
    Metal bindingi231 – 2311Magnesium 1UniRule annotation
    Metal bindingi267 – 2671Magnesium 1UniRule annotation
    Metal bindingi267 – 2671Magnesium 2UniRule annotation
    Metal bindingi270 – 2701Magnesium 2UniRule annotation
    Metal bindingi295 – 2951Magnesium 1UniRule annotation
    Metal bindingi306 – 3061Magnesium 2UniRule annotation
    Metal bindingi308 – 3081Magnesium 2UniRule annotation
    Metal bindingi338 – 3381Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTWIE697303:GH3A-234-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    ORF Names:Thewi_0220Imported
    OrganismiThermoanaerobacter wiegelii Rt8.B1Imported
    Taxonomic identifieri697303 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000008276: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG2MRX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    KOiK01805.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2MRX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYFKNVPQI KYEGPKSNNP YAFKFYNPDE IIDGKPLKEH LRFSVAYWHT    50
    FTWSGTDPFG APTMQRPWDH LSDPMDIAKA RVEAAFELFE KLDVPFFCFH 100
    DRDIAPEGET LRETNKNLDT IVVMIKDYLK TSKTKVLWGT ANLFSNPRFV 150
    HGAATSCNAD VFAYAAAQVK KALEITKELG GQNYVFWGGR EGYETLLNTD 200
    MELEFDNLAR FLHMAVEYAQ EIGFEGQFLI EPKPKEPTKH QYDFDAASVH 250
    AFLKKYDLDK YFKLNIEANH ATLAGHDFQH ELRYARINNM LGSIDANMGD 300
    MLLGWDTDQY PTDIRMTTLA MYEVIKMGGF NKGGLNFDAK VRRASFEPED 350
    LFLGHIAGMD AFAKGFKVAY KIVKDGVFDR FIEERYKSYR EGIGAEIVNG 400
    KANFKTLEEY ALNNPKIENK SGKQELLESI LNQYLFSE 438
    Length:438
    Mass (Da):50,287
    Last modified:November 16, 2011 - v1
    Checksum:i4AEC61D56B32C645
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002991 Genomic DNA. Translation: AEM77724.1.
    RefSeqiYP_004819008.1. NC_015958.1.

    Genome annotation databases

    EnsemblBacteriaiAEM77724; AEM77724; Thewi_0220.
    GeneIDi11082441.
    KEGGitwi:Thewi_0220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002991 Genomic DNA. Translation: AEM77724.1 .
    RefSeqi YP_004819008.1. NC_015958.1.

    3D structure databases

    ProteinModelPortali G2MRX8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEM77724 ; AEM77724 ; Thewi_0220 .
    GeneIDi 11082441.
    KEGGi twi:Thewi_0220.

    Phylogenomic databases

    KOi K01805.

    Enzyme and pathway databases

    BioCyci TWIE697303:GH3A-234-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Thermoanaerobacter wiegelii Rt8.B1."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Zeytun A., Daligault H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Hemme C., Woyke T.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Rt8.B1Imported.

    Entry informationi

    Entry nameiG2MRX8_9THEO
    AccessioniPrimary (citable) accession number: G2MRX8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3