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G2MME4

- G2MME4_9ARCH

UniProt

G2MME4 - G2MME4_9ARCH

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
halophilic archaeon DL31
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHARC756883:GJDQ-2011-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:lysSUniRule annotation
    ORF Names:Halar_2699Imported
    Organismihalophilic archaeon DL31Imported
    Taxonomic identifieri756883 [NCBI]
    Taxonomic lineageiArchaea
    ProteomesiUP000010096: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499"HIGH" regionUniRule annotation
    Motifi307 – 3115"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    KOiK04566.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00177. Lys_tRNA_synth_class1.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01921. tRNA-synt_1f. 1 hit.
    [Graphical view]
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2MME4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDDRHGDR SFHAFWADTV ADEIEASEPE EPIVIKGGVS PSGIPHLGHF    50
    NEILRGHFVA EVLRERGHEV RQVFMSDDRD PLRKLPRRLA DADWNVVELG 100
    DVDAGALGKN LGKPYTDIPD PFGECHDSYG EHFADLLSQA ADMVDVPVEV 150
    LSNTEMYESG EFEPQIRTIL ENVETAREVL AGYQNSVDES YSPFRVVCQE 200
    CGIVTTDVTV TDLGEGIVSY ACTGMTAGGR DIEGCGHEGE ATLRDGKLSW 250
    RFEWPAQWSL LGVDFEPFGK DHAEGSWPSG EEIMREVLGE EPPVPMTYEW 300
    FTLNGEPLSS SEGNVVTVPE VLELLEPEVL RYFFALDPNK ARDFDVSRLD 350
    QLVDDFDRFE RAHFGDVDDE ELTRVAERAY PFVVDEVRAD RVRLPYTFAA 400
    VLGMVDDRHL RLQMAQNEGH IPEDAPEWVV DDALARVEKA RAWAERCDNA 450
    YNYRLQPDLP DAAFDDAVAA ALDELAAFVE AGNDGEAIQG EIYETAKRHD 500
    IEVGDLFAAG YRLFFDQTQG PRLGEFMGEL DREFVVQRLR RDG 543
    Length:543
    Mass (Da):60,899
    Last modified:November 16, 2011 - v1
    Checksum:i020D9BB14C6A1BDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002988 Genomic DNA. Translation: AEN06343.1.
    RefSeqiWP_014052114.1. NC_015954.1.
    YP_004808716.1. NC_015954.1.

    Genome annotation databases

    EnsemblBacteriaiAEN06343; AEN06343; Halar_2699.
    GeneIDi11096068.
    KEGGihah:Halar_2699.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002988 Genomic DNA. Translation: AEN06343.1 .
    RefSeqi WP_014052114.1. NC_015954.1.
    YP_004808716.1. NC_015954.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN06343 ; AEN06343 ; Halar_2699 .
    GeneIDi 11096068.
    KEGGi hah:Halar_2699.

    Phylogenomic databases

    KOi K04566.

    Enzyme and pathway databases

    BioCyci HARC756883:GJDQ-2011-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00177. Lys_tRNA_synth_class1.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01921. tRNA-synt_1f. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of halophilic archaeon DL31."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Dyall-Smith M., Cavicchioli R., Woyke T.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DL31Imported.

    Entry informationi

    Entry nameiG2MME4_9ARCH
    AccessioniPrimary (citable) accession number: G2MME4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3