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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
halophilic archaeon DL31
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHARC756883:GJDQ-2011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:lysSUniRule annotation
ORF Names:Halar_2699Imported
Organismihalophilic archaeon DL31Imported
Taxonomic identifieri756883 [NCBI]
Taxonomic lineageiArchaea
ProteomesiUP000010096 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499"HIGH" regionUniRule annotation
Motifi307 – 3115"KMSKS" regionUniRule annotation

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK04566.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2MME4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDDRHGDR SFHAFWADTV ADEIEASEPE EPIVIKGGVS PSGIPHLGHF
60 70 80 90 100
NEILRGHFVA EVLRERGHEV RQVFMSDDRD PLRKLPRRLA DADWNVVELG
110 120 130 140 150
DVDAGALGKN LGKPYTDIPD PFGECHDSYG EHFADLLSQA ADMVDVPVEV
160 170 180 190 200
LSNTEMYESG EFEPQIRTIL ENVETAREVL AGYQNSVDES YSPFRVVCQE
210 220 230 240 250
CGIVTTDVTV TDLGEGIVSY ACTGMTAGGR DIEGCGHEGE ATLRDGKLSW
260 270 280 290 300
RFEWPAQWSL LGVDFEPFGK DHAEGSWPSG EEIMREVLGE EPPVPMTYEW
310 320 330 340 350
FTLNGEPLSS SEGNVVTVPE VLELLEPEVL RYFFALDPNK ARDFDVSRLD
360 370 380 390 400
QLVDDFDRFE RAHFGDVDDE ELTRVAERAY PFVVDEVRAD RVRLPYTFAA
410 420 430 440 450
VLGMVDDRHL RLQMAQNEGH IPEDAPEWVV DDALARVEKA RAWAERCDNA
460 470 480 490 500
YNYRLQPDLP DAAFDDAVAA ALDELAAFVE AGNDGEAIQG EIYETAKRHD
510 520 530 540
IEVGDLFAAG YRLFFDQTQG PRLGEFMGEL DREFVVQRLR RDG
Length:543
Mass (Da):60,899
Last modified:November 16, 2011 - v1
Checksum:i020D9BB14C6A1BDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002988 Genomic DNA. Translation: AEN06343.1.
RefSeqiWP_014052114.1. NC_015954.1.
YP_004808716.1. NC_015954.1.

Genome annotation databases

EnsemblBacteriaiAEN06343; AEN06343; Halar_2699.
GeneIDi11096068.
KEGGihah:Halar_2699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002988 Genomic DNA. Translation: AEN06343.1.
RefSeqiWP_014052114.1. NC_015954.1.
YP_004808716.1. NC_015954.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEN06343; AEN06343; Halar_2699.
GeneIDi11096068.
KEGGihah:Halar_2699.

Phylogenomic databases

KOiK04566.

Enzyme and pathway databases

BioCyciHARC756883:GJDQ-2011-MONOMER.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of halophilic archaeon DL31."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Dyall-Smith M., Cavicchioli R., Woyke T.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DL31Imported.

Entry informationi

Entry nameiG2MME4_9ARCH
AccessioniPrimary (citable) accession number: G2MME4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: January 7, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.