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Protein

Thymidine kinase

Gene

tdk

Organism
halophilic archaeon DL31
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1
Metal bindingi189ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi91 – 94ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:Halar_1545Imported
Organismihalophilic archaeon DL31Imported
Taxonomic identifieri756883 [NCBI]
Taxonomic lineageiArchaea
Proteomesi
  • UP000010096 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi756883.Halar_1545.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04798. Archaea.
COG1435. LUCA.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2MJ45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKITGSGWV EVVTGSMFSG KTEELLRRLR RAEIAGQDVI AFTPAIDDRY
60 70 80 90 100
GDTTIGSHEG RQWDAQVVDN EGAGVWDIED HLNGQEVVAI DEANFFDNDL
110 120 130 140 150
VDVCEKLAAD GRRVVVSGTD ITFRGEPFTP LPAVMATAEY VDKLRAICSV
160 170 180 190
CGEPATRNQR LVDGEPAHID DPTIVVGAEE SYEARCRNCH TLRSD
Length:195
Mass (Da):21,406
Last modified:November 16, 2011 - v1
Checksum:iAC18615DB583E9C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002988 Genomic DNA. Translation: AEN05277.1.
RefSeqiWP_014051056.1. NC_015954.1.

Genome annotation databases

EnsemblBacteriaiAEN05277; AEN05277; Halar_1545.
KEGGihah:Halar_1545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002988 Genomic DNA. Translation: AEN05277.1.
RefSeqiWP_014051056.1. NC_015954.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi756883.Halar_1545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEN05277; AEN05277; Halar_1545.
KEGGihah:Halar_1545.

Phylogenomic databases

eggNOGiarCOG04798. Archaea.
COG1435. LUCA.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG2MJ45_9ARCH
AccessioniPrimary (citable) accession number: G2MJ45
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 2, 2016
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.