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G2MJ45

- G2MJ45_9ARCH

UniProt

G2MJ45 - G2MJ45_9ARCH

Protein

Thymidine kinase

Gene

tdk

Organism
halophilic archaeon DL31
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921Proton acceptorUniRule annotation
    Metal bindingi148 – 1481ZincUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation
    Metal bindingi189 – 1891ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPUniRule annotation
    Nucleotide bindingi91 – 944ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciHARC756883:GJDQ-835-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    ORF Names:Halar_1545Imported
    Organismihalophilic archaeon DL31Imported
    Taxonomic identifieri756883 [NCBI]
    Taxonomic lineageiArchaea
    ProteomesiUP000010096: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2MJ45-1 [UniParc]FASTAAdd to Basket

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    MHKITGSGWV EVVTGSMFSG KTEELLRRLR RAEIAGQDVI AFTPAIDDRY    50
    GDTTIGSHEG RQWDAQVVDN EGAGVWDIED HLNGQEVVAI DEANFFDNDL 100
    VDVCEKLAAD GRRVVVSGTD ITFRGEPFTP LPAVMATAEY VDKLRAICSV 150
    CGEPATRNQR LVDGEPAHID DPTIVVGAEE SYEARCRNCH TLRSD 195
    Length:195
    Mass (Da):21,406
    Last modified:November 16, 2011 - v1
    Checksum:iAC18615DB583E9C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002988 Genomic DNA. Translation: AEN05277.1.
    RefSeqiWP_014051056.1. NC_015954.1.
    YP_004807650.1. NC_015954.1.

    Genome annotation databases

    EnsemblBacteriaiAEN05277; AEN05277; Halar_1545.
    GeneIDi11094892.
    KEGGihah:Halar_1545.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002988 Genomic DNA. Translation: AEN05277.1 .
    RefSeqi WP_014051056.1. NC_015954.1.
    YP_004807650.1. NC_015954.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN05277 ; AEN05277 ; Halar_1545 .
    GeneIDi 11094892.
    KEGGi hah:Halar_1545.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci HARC756883:GJDQ-835-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of halophilic archaeon DL31."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Dyall-Smith M., Cavicchioli R., Woyke T.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DL31Imported.

    Entry informationi

    Entry nameiG2MJ45_9ARCH
    AccessioniPrimary (citable) accession number: G2MJ45
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3