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G2MBN6

- G2MBN6_HELPX

UniProt

G2MBN6 - G2MBN6_HELPX

Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Helicobacter pylori SNT49
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

    Catalytic activityi

    ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei317 – 3171Coenzyme AUniRule annotation
    Binding sitei393 – 3931Substrate; via nitrogen amideUniRule annotation
    Binding sitei510 – 5101SubstrateUniRule annotation
    Binding sitei525 – 5251SubstrateUniRule annotation
    Active sitei527 – 5271UniRule annotation
    Binding sitei533 – 5331Coenzyme AUniRule annotation
    Binding sitei536 – 5361SubstrateUniRule annotation
    Metal bindingi549 – 5491Magnesium; via carbonyl oxygenUniRule annotation
    Metal bindingi552 – 5521Magnesium; via carbonyl oxygenUniRule annotation
    Binding sitei598 – 5981Coenzyme AUniRule annotation

    GO - Molecular functioni

    1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
    2. AMP binding Source: InterPro
    3. ATP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from acetate Source: InterPro

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL1055530:GLER-417-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
    Short name:
    AcCoA synthetaseUniRule annotation
    Short name:
    AcsUniRule annotation
    Alternative name(s):
    Acetate--CoA ligaseUniRule annotation
    Acyl-activating enzymeUniRule annotation
    Gene namesi
    Name:acsAUniRule annotation
    ORF Names:HPSNT_02160Imported
    OrganismiHelicobacter pylori SNT49Imported
    Taxonomic identifieri1055530 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008534: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei623 – 6231N6-acetyllysineUniRule annotation

    Post-translational modificationi

    Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

    Keywords - PTMi

    AcetylationUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG2MBN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni417 – 4226Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Phylogenomic databases

    KOiK01895.

    Family and domain databases

    HAMAPiMF_01123. Ac_CoA_synth.
    InterProiIPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2MBN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLDDDLEFA KKVFNPNKAF AKQARIKNMC EYKDLVHEAN EDYEHFWGEL    50
    ATQKLTWFKP FDKVLNNDNA PFFKWFENGK INVSYNCIDR HLKDKKNKVA 100
    IIFEGEMGDY NVITYRKLHS EVNKTANLLK NEFNVKKGDR VIIYMPMIVE 150
    SVYMMLACAR IGAIHSIVFA GFSPEALRDR INDTQAKLVI TADGTFRKGK 200
    PYMLKPALDK ALENNACPSV EKALIVIRNA KEIDYVRGRD FVYNEMVNYQ 250
    SDKCEPEMID SEDPLFLLYT SGSTGKPKGV QHSSAGYLLW AQMTMEWVFD 300
    IRDNDNFWCT ADIGWITGHT YVVYGPLACG ATTLILEGTM SYPDYGRWWR 350
    MIEEYRVDKF YTSPTAIRML HAKGENEPLK YNLDSLKVLG TVGEPINPTA 400
    WKWFYEKIGN SKCSIVDTWW QTETGGHIIS PLPGATPIRT SCATLPLPGI 450
    HAEVLNEDGT KTKPGEQGFL CITKPWPSMI RNIWGDEKRY IDSYFSQIKL 500
    NGEYVYLSGD GAIVDENGYI TIIGRTDDIV NVSGHRIGTA EVESAISKHE 550
    MVVECAVVGI PDTIKGEGLF AFVVLCDGAK CNLGESLELL KEMNHILSIE 600
    IGKIAKLDNV MYVPGLPKTR SGKIMRRLLK SIAKKEPITQ DLSTLEDVNV 650
    VKEIMSIVQM EE 662
    Length:662
    Mass (Da):75,016
    Last modified:November 16, 2011 - v1
    Checksum:iCA8F414A35DC6297
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002983 Genomic DNA. Translation: AEN16601.1.
    RefSeqiYP_005786582.1. NC_017376.1.

    Genome annotation databases

    EnsemblBacteriaiAEN16601; AEN16601; HPSNT_02160.
    GeneIDi12366847.
    KEGGihen:HPSNT_02160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002983 Genomic DNA. Translation: AEN16601.1 .
    RefSeqi YP_005786582.1. NC_017376.1.

    3D structure databases

    ProteinModelPortali G2MBN6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEN16601 ; AEN16601 ; HPSNT_02160 .
    GeneIDi 12366847.
    KEGGi hen:HPSNT_02160.

    Phylogenomic databases

    KOi K01895.

    Enzyme and pathway databases

    BioCyci HPYL1055530:GLER-417-MONOMER.

    Family and domain databases

    HAMAPi MF_01123. Ac_CoA_synth.
    InterProi IPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kersulyte D., Choudhury A., Mukhopadhyay A.K., Nair G.B., Berg D.E.
      Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Santal49Imported.

    Entry informationi

    Entry nameiG2MBN6_HELPX
    AccessioniPrimary (citable) accession number: G2MBN6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3