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G2MBN6

- G2MBN6_HELPX

UniProt

G2MBN6 - G2MBN6_HELPX

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Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Helicobacter pylori SNT49
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei317 – 3171Coenzyme AUniRule annotation
Binding sitei510 – 5101ATPUniRule annotation
Binding sitei525 – 5251ATPUniRule annotation
Binding sitei533 – 5331Coenzyme A; via carbonyl oxygenUniRule annotation
Binding sitei536 – 5361ATPUniRule annotation
Metal bindingi549 – 5491Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi552 – 5521Magnesium; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi393 – 3953ATPUniRule annotation
Nucleotide bindingi417 – 4226ATPUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL1055530:GLER-417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligaseUniRule annotation
Acyl-activating enzymeUniRule annotation
Gene namesi
Name:acsAUniRule annotation
ORF Names:HPSNT_02160Imported
OrganismiHelicobacter pylori SNT49Imported
Taxonomic identifieri1055530 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008534: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei623 – 6231N6-acetyllysineUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG2MBN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni197 – 2004Coenzyme A bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

KOiK01895.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2MBN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLDDDLEFA KKVFNPNKAF AKQARIKNMC EYKDLVHEAN EDYEHFWGEL
60 70 80 90 100
ATQKLTWFKP FDKVLNNDNA PFFKWFENGK INVSYNCIDR HLKDKKNKVA
110 120 130 140 150
IIFEGEMGDY NVITYRKLHS EVNKTANLLK NEFNVKKGDR VIIYMPMIVE
160 170 180 190 200
SVYMMLACAR IGAIHSIVFA GFSPEALRDR INDTQAKLVI TADGTFRKGK
210 220 230 240 250
PYMLKPALDK ALENNACPSV EKALIVIRNA KEIDYVRGRD FVYNEMVNYQ
260 270 280 290 300
SDKCEPEMID SEDPLFLLYT SGSTGKPKGV QHSSAGYLLW AQMTMEWVFD
310 320 330 340 350
IRDNDNFWCT ADIGWITGHT YVVYGPLACG ATTLILEGTM SYPDYGRWWR
360 370 380 390 400
MIEEYRVDKF YTSPTAIRML HAKGENEPLK YNLDSLKVLG TVGEPINPTA
410 420 430 440 450
WKWFYEKIGN SKCSIVDTWW QTETGGHIIS PLPGATPIRT SCATLPLPGI
460 470 480 490 500
HAEVLNEDGT KTKPGEQGFL CITKPWPSMI RNIWGDEKRY IDSYFSQIKL
510 520 530 540 550
NGEYVYLSGD GAIVDENGYI TIIGRTDDIV NVSGHRIGTA EVESAISKHE
560 570 580 590 600
MVVECAVVGI PDTIKGEGLF AFVVLCDGAK CNLGESLELL KEMNHILSIE
610 620 630 640 650
IGKIAKLDNV MYVPGLPKTR SGKIMRRLLK SIAKKEPITQ DLSTLEDVNV
660
VKEIMSIVQM EE
Length:662
Mass (Da):75,016
Last modified:November 16, 2011 - v1
Checksum:iCA8F414A35DC6297
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002983 Genomic DNA. Translation: AEN16601.1.
RefSeqiWP_001175392.1. NC_017376.1.
YP_005786582.1. NC_017376.1.

Genome annotation databases

EnsemblBacteriaiAEN16601; AEN16601; HPSNT_02160.
GeneIDi12366847.
KEGGihen:HPSNT_02160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002983 Genomic DNA. Translation: AEN16601.1 .
RefSeqi WP_001175392.1. NC_017376.1.
YP_005786582.1. NC_017376.1.

3D structure databases

ProteinModelPortali G2MBN6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEN16601 ; AEN16601 ; HPSNT_02160 .
GeneIDi 12366847.
KEGGi hen:HPSNT_02160.

Phylogenomic databases

KOi K01895.

Enzyme and pathway databases

BioCyci HPYL1055530:GLER-417-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kersulyte D., Choudhury A., Mukhopadhyay A.K., Nair G.B., Berg D.E.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Santal49Imported.

Entry informationi

Entry nameiG2MBN6_HELPX
AccessioniPrimary (citable) accession number: G2MBN6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3