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Protein

Dihydrofolate reductase

Gene

folA

Organism
Buchnera aphidicola str. Ua (Uroleucon ambrosiae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (folA)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

BioCyciBAPH1005057:G1H04-132-MONOMER
UniPathwayiUPA00077; UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
Name:folAImported
ORF Names:BUAMB_131Imported
OrganismiBuchnera aphidicola str. Ua (Uroleucon ambrosiae)Imported
Taxonomic identifieri1005057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000006139 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1005057.BUAMB_131

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 168DHFRInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YYV Bacteria
COG0262 LUCA
KOiK00287
OrthoDBiPOG091H01KY

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.101 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

G2LP19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISLIAAIS KNLIIGYQNK IPWYIPNDLK WFKKNTIHKN IIMGRVTWES
60 70 80 90 100
IAQPLSHRRN IVISKTEIKN KNVIWCHSIS DAISNAVSNI IVSKKYQQEI
110 120 130 140 150
MVIGGEKIYK QMLFYANKLY LTNIDIDIIG DSYFPQYMLY PSWKILFKQN
160
NIKNKFNPYN YSFQILSR
Length:168
Mass (Da):19,826
Last modified:November 16, 2011 - v1
Checksum:iF2DD5D07E6A5EC06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002648 Genomic DNA Translation: AEO07956.1
RefSeqiWP_014499860.1, NC_017259.1

Genome annotation databases

EnsemblBacteriaiAEO07956; AEO07956; BUAMB_131
KEGGibuh:BUAMB_131
PATRICifig|1005057.4.peg.123

Similar proteinsi

Entry informationi

Entry nameiG2LP19_BUCUM
AccessioniPrimary (citable) accession number: G2LP19
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported