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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA1

Organism
Lactobacillus sanfranciscensis (strain TMW 1.1304)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA1), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA2)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Active sitei97Proton donor/acceptorUniRule annotation1
Binding sitei108SubstrateUniRule annotation1
Sitei186Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmA1Imported
Synonyms:gpmAUniRule annotation
Ordered Locus Names:LSA_04440Imported
OrganismiLactobacillus sanfranciscensis (strain TMW 1.1304)Imported
Taxonomic identifieri714313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001285 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi714313.LSA_04440

Structurei

3D structure databases

ProteinModelPortaliG2KV03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 25Substrate bindingUniRule annotation8
Regioni31 – 32Substrate bindingUniRule annotation2
Regioni97 – 100Substrate bindingUniRule annotation4
Regioni124 – 125Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108K79 Bacteria
COG0588 LUCA
KOiK01834
OMAiNLHAVGP
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

G2KV03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKRVSEVDY MSKLVLMRHG ESVANYNHTF TGWSDVSLTD EGRREAHEAG
60 70 80 90 100
RKLNELQIKF DDAHTSYLKR AIISENIVLS EINQLWIPQH KTWRLNERHY
110 120 130 140 150
GALRGQNKQK VRAEVGDEQF MMWRRSFEAV PPRLEVVPDL RRYHDAGIDE
160 170 180 190 200
PRAESLKMAY QRLVPYWIDE IAPRLMNNHN QLVIAHGSSL RALIKYLENI
210 220 230
DDLGIDGVEV GNAEPIIYTL DHDLRILKKE ILN
Length:233
Mass (Da):27,196
Last modified:November 16, 2011 - v1
Checksum:i95CAF36FC1E1B45E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002461 Genomic DNA Translation: AEN98892.1

Genome annotation databases

EnsemblBacteriaiAEN98892; AEN98892; LSA_04440
KEGGilsn:LSA_04440

Similar proteinsi

Entry informationi

Entry nameiG2KV03_LACSM
AccessioniPrimary (citable) accession number: G2KV03
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health