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G2K4Q7 (ALR_LISM4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Synonyms:dal
Ordered Locus Names:LMRG_02310
OrganismListeria monocytogenes serotype 1/2a (strain 10403S) [Complete proteome] [HAMAP]
Taxonomic identifier393133 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Alanine racemase HAMAP-Rule MF_01201
PRO_0000418517

Sites

Active site401Proton acceptor; specific for D-alanine By similarity
Active site2631Proton acceptor; specific for L-alanine By similarity
Binding site1341Substrate By similarity
Binding site3101Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
G2K4Q7 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: E3D66B1952DC2959

FASTA36841,029
        10         20         30         40         50         60 
MVTGWHRPTW IEIDRAAIRE NIKNEQNKLP ESVDLWAVVK ANAYGHGIIE VARTAKEAGA 

        70         80         90        100        110        120 
KGFCVAILDE ALALREAGFQ DDFILVLGAT RKEDANLAAK NHISLTVFRE DWLENLTLEA 

       130        140        150        160        170        180 
TLRIHLKVDS GMGRLGIRTT EEARRIEATS TNDHQLQLEG IYTHFATADQ LETSYFEQQL 

       190        200        210        220        230        240 
AKFQTILTSL KKRPTYVHTA NSAASLLQPQ IGFDAIRFGI SMYGLTPSTE IKTSLPFELK 

       250        260        270        280        290        300 
PALALYTEMV HVKELAPGDS VSYGATYTAT EREWVATLPI GYADGLIRHY SGFHVLVDGE 

       310        320        330        340        350        360 
PAPIIGRVCM DQTIIKLPRE FQTGSKVTII GKDHGNTVTA DDAAQYLDTI NYEVTCLLNE 


RIPRKYIH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038438 Genomic DNA. Translation: AAC31362.1.
CP002002 Genomic DNA. Translation: AEO05885.1.
RefSeqYP_005962016.1. NC_017544.1.
YP_008297201.1. NC_021837.1.

3D structure databases

ProteinModelPortalG2K4Q7.
SMRG2K4Q7. Positions 4-367.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEO05885; AEO05885; LMRG_02310.
GeneID12553107.
16334349.
KEGGlmt:LMRG_02310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.

Enzyme and pathway databases

UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_LISM4
AccessionPrimary (citable) accession number: G2K4Q7
Secondary accession number(s): O85045
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 16, 2011
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways