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G2K4Q7

- ALR_LISM4

UniProt

G2K4Q7 - ALR_LISM4

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Protein

Alanine racemase

Gene

alr

Organism
Listeria monocytogenes serotype 1/2a (strain 10403S)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Synonyms:dal
Ordered Locus Names:LMRG_02310
OrganismiListeria monocytogenes serotype 1/2a (strain 10403S)
Taxonomic identifieri393133 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000001288: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Alanine racemasePRO_0000418517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG2K4Q7.
SMRiG2K4Q7. Positions 4-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2K4Q7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTGWHRPTW IEIDRAAIRE NIKNEQNKLP ESVDLWAVVK ANAYGHGIIE
60 70 80 90 100
VARTAKEAGA KGFCVAILDE ALALREAGFQ DDFILVLGAT RKEDANLAAK
110 120 130 140 150
NHISLTVFRE DWLENLTLEA TLRIHLKVDS GMGRLGIRTT EEARRIEATS
160 170 180 190 200
TNDHQLQLEG IYTHFATADQ LETSYFEQQL AKFQTILTSL KKRPTYVHTA
210 220 230 240 250
NSAASLLQPQ IGFDAIRFGI SMYGLTPSTE IKTSLPFELK PALALYTEMV
260 270 280 290 300
HVKELAPGDS VSYGATYTAT EREWVATLPI GYADGLIRHY SGFHVLVDGE
310 320 330 340 350
PAPIIGRVCM DQTIIKLPRE FQTGSKVTII GKDHGNTVTA DDAAQYLDTI
360
NYEVTCLLNE RIPRKYIH
Length:368
Mass (Da):41,029
Last modified:November 16, 2011 - v1
Checksum:iE3D66B1952DC2959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038438 Genomic DNA. Translation: AAC31362.1.
CP002002 Genomic DNA. Translation: AEO05885.1.
RefSeqiWP_014600669.1. NC_017544.1.
YP_005962016.1. NC_017544.1.
YP_008297201.1. NC_021837.1.

Genome annotation databases

EnsemblBacteriaiAEO05885; AEO05885; LMRG_02310.
GeneIDi12553107.
16334349.
KEGGilmt:LMRG_02310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038438 Genomic DNA. Translation: AAC31362.1 .
CP002002 Genomic DNA. Translation: AEO05885.1 .
RefSeqi WP_014600669.1. NC_017544.1.
YP_005962016.1. NC_017544.1.
YP_008297201.1. NC_021837.1.

3D structure databases

ProteinModelPortali G2K4Q7.
SMRi G2K4Q7. Positions 4-367.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEO05885 ; AEO05885 ; LMRG_02310 .
GeneIDi 12553107.
16334349.
KEGGi lmt:LMRG_02310.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth."
    Thompson R.J., Bouwer H.G.A., Portnoy D.A., Frankel F.R.
    Infect. Immun. 66:3552-3561(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 10403S.
  2. "The genome sequence of Listeria monocytogenes strain 10403S."
    The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
    Borowsky M., Borodovsky M., Young S.K., Zeng Q., Koehrsen M., Fitzgerald M., Wiedmann M., Swaminathan B., Lauer P., Portnoy D., Cossart P., Buchrieser C., Higgins D., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Borenstein D.
    , Brown A., Chapman S.B., Chen Z., Dunbar C.D., Engels R., Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L., Lui A., MacDonald J., Mehta T., Montmayeur A., Neiman D., Park D., Pearson M., Priest M., Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 10403S.

Entry informationi

Entry nameiALR_LISM4
AccessioniPrimary (citable) accession number: G2K4Q7
Secondary accession number(s): O85045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 16, 2011
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3