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Protein

Glutamate decarboxylase

Gene

LMRG_00139

Organism
Listeria monocytogenes serotype 1/2a (strain 10403S)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:LMRG_00139Imported
OrganismiListeria monocytogenes serotype 1/2a (strain 10403S)Imported
Taxonomic identifieri393133 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000001288: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG2K3H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

G2K3H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKTNVEQNN VPVFGSFESG QDLPEKRMNK ESVDPRIAYQ LVKDQLIDEG
60 70 80 90 100
SARQNLATFC QTYMEPEAEQ IMAETMEKNA IDKSEYPQTA KLESSCVNML
110 120 130 140 150
ADLWNVDESE HYMGTSTVGS SEACMLGGMA MKFRWRSAAL KNGLDIHAKK
160 170 180 190 200
PNLVISSGYQ VCWEKFCVYW DIELREVPMS EEHLSINTDI IMDYVDEYTI
210 220 230 240 250
GIVGILGITY TGKFDDIMTL NDLVEDYNNT HDNEVVIHVD GASGAMFTPF
260 270 280 290 300
VEPGLEWDFR LPNVVSINTS GHKYGLVYPG VGWILWRDKE YLPEELVFDV
310 320 330 340 350
SYLGGHMPTM AINFSRSASQ IIGQYYNFLR FGYEGYRQIH MRTRDGALQL
360 370 380 390 400
SQAVAETGLF EIYNDGANLP IVCYKLKDDA NVAWTLYDLA DRLQMKGWQV
410 420 430 440 450
PAYPLPKEMG NTIIQRYVCR GDLGQNMVTA FKNDLSESIE ELNNAHILYH
460
DVNTSKTHGF TH
Length:462
Mass (Da):52,525
Last modified:November 16, 2011 - v1
Checksum:iD31D66FBCE101B6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002002 Genomic DNA. Translation: AEO05457.1.
RefSeqiYP_005961588.1. NC_017544.1.

Genome annotation databases

EnsemblBacteriaiAEO05457; AEO05457; LMRG_00139.
GeneIDi12552674.
KEGGilmt:LMRG_00139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002002 Genomic DNA. Translation: AEO05457.1.
RefSeqiYP_005961588.1. NC_017544.1.

3D structure databases

ProteinModelPortaliG2K3H9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEO05457; AEO05457; LMRG_00139.
GeneIDi12552674.
KEGGilmt:LMRG_00139.

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Listeria monocytogenes strain 10403S."
    The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease.
    Borowsky M., Borodovsky M., Young S.K., Zeng Q., Koehrsen M., Fitzgerald M., Wiedmann M., Swaminathan B., Lauer P., Portnoy D., Cossart P., Buchrieser C., Higgins D., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Borenstein D.
    , Brown A., Chapman S.B., Chen Z., Dunbar C.D., Engels R., Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L., Lui A., MacDonald J., Mehta T., Montmayeur A., Neiman D., Park D., Pearson M., Priest M., Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 10403SImported.

Entry informationi

Entry nameiG2K3H9_LISM4
AccessioniPrimary (citable) accession number: G2K3H9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.