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G2JN22 (G2JN22_ACIBA) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit I HAMAP-Rule MF_01351
EC=1.6.99.5 HAMAP-Rule MF_01351
Alternative name(s):
NADH dehydrogenase I subunit I HAMAP-Rule MF_01351
NDH-1 subunit I HAMAP-Rule MF_01351
Gene names
Name:nuoI HAMAP-Rule MF_01351
ORF Names:ABZJ_00757 EMBL AEP05217.1
OrganismAcinetobacter baumannii MDR-ZJ06 EMBL AEP05217.1
Taxonomic identifier497978 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex ›

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01351

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01351

Cofactor

Binds 2 4Fe-4S clusters per subunit By similarity. HAMAP-Rule MF_01351 SAAS SAAS012285

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity. HAMAP-Rule MF_01351

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01351.

Sequence similarities

Belongs to the complex I 23 kDa subunit family. HAMAP-Rule MF_01351

Contains 2 4Fe-4S ferredoxin-type domains. HAMAP-Rule MF_01351

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain50 – 80314Fe-4S ferredoxin-type 1 By similarity HAMAP-Rule MF_01351
Domain90 – 119304Fe-4S ferredoxin-type 2 By similarity HAMAP-Rule MF_01351

Sites

Metal binding601Iron-sulfur 1 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding631Iron-sulfur 1 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding661Iron-sulfur 1 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding701Iron-sulfur 2 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding991Iron-sulfur 2 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding1021Iron-sulfur 2 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding1051Iron-sulfur 2 (4Fe-4S) By similarity HAMAP-Rule MF_01351
Metal binding1091Iron-sulfur 1 (4Fe-4S) By similarity HAMAP-Rule MF_01351

Sequences

Sequence LengthMass (Da)Tools
G2JN22 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: EDD9891B14A68EC6

FASTA18020,432
        10         20         30         40         50         60 
MYKILAGVGS IVRTLFMVFT HGFRKRDTIL YPEVPAEEIV PPRYRGRIIL TRDPDGEERC 

        70         80         90        100        110        120 
VACNLCAVAC PVGCISLQKA EKEDGRWYPE FFRINFSRCI FCGMCEEACP TTAIQLTPDF 

       130        140        150        160        170        180 
ELGEYVRQDL VYEKENLLIS GPGKYPDYNF YRVTGMAING KEKGQAQKES APIDVRSLLP

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References

[1]"Genomic Analysis of the Multidrug-Resistant Acinetobacter baumannii Strain MDR-ZJ06 Widely Spread in China."
Zhou H., Zhang T., Yu D., Pi B., Yang Q., Zhou J., Hu S., Yu Y.
Antimicrob. Agents Chemother. 55:4506-4512(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MDR-ZJ06 EMBL AEP05217.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001937 Genomic DNA. Translation: AEP05217.1.
RefSeqYP_005524713.1. NC_017171.1.

3D structure databases

ProteinModelPortalG2JN22.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEP05217; AEP05217; ABZJ_00757.
GeneID12116508.
KEGGabz:ABZJ_00757.

Phylogenomic databases

KOK00338.

Enzyme and pathway databases

BioCycABAU497978:GL7S-787-MONOMER.

Family and domain databases

Gene3D1.10.1060.10. 1 hit.
HAMAPMF_01351. NDH1_NuoI.
InterProIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012285. Fum_reductase_C.
IPR010226. NADH_quinone_OxRdtase_chainI.
[Graphical view]
PfamPF12838. Fer4_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR01971. NuoI. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG2JN22_ACIBA
AccessionPrimary (citable) accession number: G2JN22
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 29, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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