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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Candidatus Arthromitus sp. SFB-rat-Yit
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

BioCyciCART1041504:G1H7S-817-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:RATSFB_0757Imported
OrganismiCandidatus Arthromitus sp. SFB-rat-YitImported
Taxonomic identifieri1041504 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeCandidatus Arthromitus
Proteomesi
  • UP000001273 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 30HelicalUniRule annotationAdd BLAST25
Transmembranei51 – 72HelicalUniRule annotationAdd BLAST22
Transmembranei84 – 103HelicalUniRule annotationAdd BLAST20
Transmembranei115 – 133HelicalUniRule annotationAdd BLAST19
Transmembranei153 – 174HelicalUniRule annotationAdd BLAST22
Transmembranei181 – 199HelicalUniRule annotationAdd BLAST19
Transmembranei205 – 222HelicalUniRule annotationAdd BLAST18
Transmembranei229 – 250HelicalUniRule annotationAdd BLAST22
Transmembranei256 – 277HelicalUniRule annotationAdd BLAST22
Transmembranei304 – 322HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi1041504.RATSFB_0757

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
KOiK01000
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

G2IDU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLLLLVLP LICSFVLAYI LGKGLIPILH RMKYGQSIRE EGPQSHFKKQ
60 70 80 90 100
GTPTMGGLIF ILATTVVTIL YSVFFAETSD GEEFIALSIF LAFGFIGFLD
110 120 130 140 150
DYLKILRKNN LGLRAYQKMF FLILITLGIY LVTKDYEDLK VIYIPFLNGY
160 170 180 190 200
INLSYFYVPF LFIYFTGVTN AVNLTDGLDG LATTVTIIVL LFLFVIGFMF
210 220 230 240 250
GKIHLSVFAF ILVGALMAFL IFNINPAKVF MGDTGSLALG GAVAAIAFIL
260 270 280 290 300
KIEFVLVFVG IIYVIETLSV IIQVLVYKCT KKRVFKMAPI HHHFEHLGWS
310 320
ENKIVCVFGA ITLIACILSW IVL
Length:323
Mass (Da):36,187
Last modified:November 16, 2011 - v1
Checksum:i3E19425813AFD278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012210 Genomic DNA Translation: BAK81319.1
RefSeqiWP_014094779.1, NC_016012.1

Genome annotation databases

EnsemblBacteriaiBAK81319; BAK81319; RATSFB_0757
KEGGiasb:RATSFB_0757

Similar proteinsi

Entry informationi

Entry nameiG2IDU5_9CLOT
AccessioniPrimary (citable) accession number: G2IDU5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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