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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Candidatus Arthromitus sp. SFB-rat-Yit
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:RATSFB_0757Imported
OrganismiCandidatus Arthromitus sp. SFB-rat-YitImported
Taxonomic identifieri1041504 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeCandidatus Arthromitus
Proteomesi
  • UP000001273 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 30HelicalUniRule annotationAdd BLAST25
Transmembranei51 – 72HelicalUniRule annotationAdd BLAST22
Transmembranei84 – 103HelicalUniRule annotationAdd BLAST20
Transmembranei115 – 133HelicalUniRule annotationAdd BLAST19
Transmembranei153 – 174HelicalUniRule annotationAdd BLAST22
Transmembranei181 – 199HelicalUniRule annotationAdd BLAST19
Transmembranei205 – 222HelicalUniRule annotationAdd BLAST18
Transmembranei229 – 250HelicalUniRule annotationAdd BLAST22
Transmembranei256 – 277HelicalUniRule annotationAdd BLAST22
Transmembranei304 – 322HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi1041504.RATSFB_0757.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
KOiK01000.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

G2IDU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLLLLVLP LICSFVLAYI LGKGLIPILH RMKYGQSIRE EGPQSHFKKQ
60 70 80 90 100
GTPTMGGLIF ILATTVVTIL YSVFFAETSD GEEFIALSIF LAFGFIGFLD
110 120 130 140 150
DYLKILRKNN LGLRAYQKMF FLILITLGIY LVTKDYEDLK VIYIPFLNGY
160 170 180 190 200
INLSYFYVPF LFIYFTGVTN AVNLTDGLDG LATTVTIIVL LFLFVIGFMF
210 220 230 240 250
GKIHLSVFAF ILVGALMAFL IFNINPAKVF MGDTGSLALG GAVAAIAFIL
260 270 280 290 300
KIEFVLVFVG IIYVIETLSV IIQVLVYKCT KKRVFKMAPI HHHFEHLGWS
310 320
ENKIVCVFGA ITLIACILSW IVL
Length:323
Mass (Da):36,187
Last modified:November 16, 2011 - v1
Checksum:i3E19425813AFD278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012210 Genomic DNA. Translation: BAK81319.1.
RefSeqiWP_014094779.1. NC_016012.1.

Genome annotation databases

EnsemblBacteriaiBAK81319; BAK81319; RATSFB_0757.
KEGGiasb:RATSFB_0757.

Similar proteinsi

Entry informationi

Entry nameiG2IDU5_9CLOT
AccessioniPrimary (citable) accession number: G2IDU5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 27, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported