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G2IAB2

- G2IAB2_9CLOT

UniProt

G2IAB2 - G2IAB2_9CLOT

Protein

Alanine racemase

Gene

alr

Organism
Candidatus Arthromitus sp. SFB-mouse-Yit
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei127 – 1271SubstrateUniRule annotation
    Active sitei250 – 2501Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei316 – 3161Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciASP1041809:GLAC-216-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    ORF Names:MOUSESFB_0199Imported
    OrganismiCandidatus Arthromitus sp. SFB-mouse-YitImported
    Taxonomic identifieri1041809 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeCandidatus Arthromitus
    ProteomesiUP000006136: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliG2IAB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2IAB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLYLEVNL YNIDKNIGII RNILGNKKFI AVVKGDAYGL GIHKICDFIK    50
    EKVDLFGVSD IDEAITLYNI GIENEILILT PIIMKEYFKN PLIEKFTVTI 100
    DNREILDFIP KELNINAHIY VCTGMNRKGI KIEELNEFIR YVENNYNNIN 150
    ITGIYTHLHN AKDEKYTLNQ IDMFKNAVLK YKGKYLIHVL NSKGFINKNI 200
    RERADFCDGI RIGNLIYGYD GSSLGISKSF NYYSKVISSY MVKKGEYVGY 250
    GNKVKLKDDT NVCILGIGNI HHIGFYREFK RNFIYDLLKF VYRYFVKPCE 300
    IYKGNTRVKI LGSSNMNLTL VDGEGLEIGD YLKVCISPIL GDSSIHKKYI 350
    IKE 353
    Length:353
    Mass (Da):40,731
    Last modified:November 16, 2011 - v1
    Checksum:i872F77D6842BB9FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012209 Genomic DNA. Translation: BAK79341.1.
    RefSeqiYP_005667917.1. NC_017294.1.

    Genome annotation databases

    EnsemblBacteriaiBAK79341; BAK79341; MOUSESFB_0199.
    GeneIDi12236639.
    KEGGiasm:MOUSESFB_0199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012209 Genomic DNA. Translation: BAK79341.1 .
    RefSeqi YP_005667917.1. NC_017294.1.

    3D structure databases

    ProteinModelPortali G2IAB2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK79341 ; BAK79341 ; MOUSESFB_0199 .
    GeneIDi 12236639.
    KEGGi asm:MOUSESFB_0199.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ASP1041809:GLAC-216-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation."
      Prakash T., Oshima K., Morita H., Fukuda S., Imaoka A., Kumar N., Sharma V.K., Kim S.-W., Takahashi M., Saitou N., Taylor T.D., Ohno H., Umesaki Y., Hattori M.
      Cell Host Microbe 10:273-284(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiG2IAB2_9CLOT
    AccessioniPrimary (citable) accession number: G2IAB2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3