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G2IAB2

- G2IAB2_9CLOT

UniProt

G2IAB2 - G2IAB2_9CLOT

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Protein
Alanine racemase
Gene
alr, MOUSESFB_0199
Organism
Candidatus Arthromitus sp. SFB-mouse-Yit
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei127 – 1271Substrate By similarityUniRule annotation
Active sitei250 – 2501Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei316 – 3161Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciASP1041809:GLAC-216-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:MOUSESFB_0199Imported
OrganismiCandidatus Arthromitus sp. SFB-mouse-YitImported
Taxonomic identifieri1041809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeCandidatus Arthromitus
ProteomesiUP000006136: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG2IAB2.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2IAB2-1 [UniParc]FASTAAdd to Basket

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MENLYLEVNL YNIDKNIGII RNILGNKKFI AVVKGDAYGL GIHKICDFIK    50
EKVDLFGVSD IDEAITLYNI GIENEILILT PIIMKEYFKN PLIEKFTVTI 100
DNREILDFIP KELNINAHIY VCTGMNRKGI KIEELNEFIR YVENNYNNIN 150
ITGIYTHLHN AKDEKYTLNQ IDMFKNAVLK YKGKYLIHVL NSKGFINKNI 200
RERADFCDGI RIGNLIYGYD GSSLGISKSF NYYSKVISSY MVKKGEYVGY 250
GNKVKLKDDT NVCILGIGNI HHIGFYREFK RNFIYDLLKF VYRYFVKPCE 300
IYKGNTRVKI LGSSNMNLTL VDGEGLEIGD YLKVCISPIL GDSSIHKKYI 350
IKE 353
Length:353
Mass (Da):40,731
Last modified:November 16, 2011 - v1
Checksum:i872F77D6842BB9FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012209 Genomic DNA. Translation: BAK79341.1.
RefSeqiYP_005667917.1. NC_017294.1.

Genome annotation databases

EnsemblBacteriaiBAK79341; BAK79341; MOUSESFB_0199.
GeneIDi12236639.
KEGGiasm:MOUSESFB_0199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012209 Genomic DNA. Translation: BAK79341.1 .
RefSeqi YP_005667917.1. NC_017294.1.

3D structure databases

ProteinModelPortali G2IAB2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK79341 ; BAK79341 ; MOUSESFB_0199 .
GeneIDi 12236639.
KEGGi asm:MOUSESFB_0199.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci ASP1041809:GLAC-216-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation."
    Prakash T., Oshima K., Morita H., Fukuda S., Imaoka A., Kumar N., Sharma V.K., Kim S.-W., Takahashi M., Saitou N., Taylor T.D., Ohno H., Umesaki Y., Hattori M.
    Cell Host Microbe 10:273-284(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiG2IAB2_9CLOT
AccessioniPrimary (citable) accession number: G2IAB2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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