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G2IAB2

- G2IAB2_9CLOT

UniProt

G2IAB2 - G2IAB2_9CLOT

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Protein

Alanine racemase

Gene

alr

Organism
Candidatus Arthromitus sp. SFB-mouse-Yit
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Active sitei250 – 2501Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei316 – 3161Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciASP1041809:GLAC-216-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:MOUSESFB_0199Imported
OrganismiCandidatus Arthromitus sp. SFB-mouse-YitImported
Taxonomic identifieri1041809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeCandidatus Arthromitus
ProteomesiUP000006136: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG2IAB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2IAB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLYLEVNL YNIDKNIGII RNILGNKKFI AVVKGDAYGL GIHKICDFIK
60 70 80 90 100
EKVDLFGVSD IDEAITLYNI GIENEILILT PIIMKEYFKN PLIEKFTVTI
110 120 130 140 150
DNREILDFIP KELNINAHIY VCTGMNRKGI KIEELNEFIR YVENNYNNIN
160 170 180 190 200
ITGIYTHLHN AKDEKYTLNQ IDMFKNAVLK YKGKYLIHVL NSKGFINKNI
210 220 230 240 250
RERADFCDGI RIGNLIYGYD GSSLGISKSF NYYSKVISSY MVKKGEYVGY
260 270 280 290 300
GNKVKLKDDT NVCILGIGNI HHIGFYREFK RNFIYDLLKF VYRYFVKPCE
310 320 330 340 350
IYKGNTRVKI LGSSNMNLTL VDGEGLEIGD YLKVCISPIL GDSSIHKKYI

IKE
Length:353
Mass (Da):40,731
Last modified:November 16, 2011 - v1
Checksum:i872F77D6842BB9FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012209 Genomic DNA. Translation: BAK79341.1.
RefSeqiYP_005667917.1. NC_017294.1.

Genome annotation databases

EnsemblBacteriaiBAK79341; BAK79341; MOUSESFB_0199.
GeneIDi12236639.
KEGGiasm:MOUSESFB_0199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012209 Genomic DNA. Translation: BAK79341.1 .
RefSeqi YP_005667917.1. NC_017294.1.

3D structure databases

ProteinModelPortali G2IAB2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK79341 ; BAK79341 ; MOUSESFB_0199 .
GeneIDi 12236639.
KEGGi asm:MOUSESFB_0199.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci ASP1041809:GLAC-216-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation."
    Prakash T., Oshima K., Morita H., Fukuda S., Imaoka A., Kumar N., Sharma V.K., Kim S.-W., Takahashi M., Saitou N., Taylor T.D., Ohno H., Umesaki Y., Hattori M.
    Cell Host Microbe 10:273-284(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiG2IAB2_9CLOT
AccessioniPrimary (citable) accession number: G2IAB2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3