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Protein
Submitted name:

Egl nine homolog 2

Gene

EGLN2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. L-ascorbic acid binding Source: InterPro
  3. oxygen sensor activity Source: Ensembl
  4. peptidyl-proline 4-dioxygenase activity Source: Ensembl

GO - Biological processi

  1. cell redox homeostasis Source: Ensembl
  2. peptidyl-proline hydroxylation to 4-hydroxy-L-proline Source: Ensembl
  3. positive regulation of protein catabolic process Source: Ensembl
  4. regulation of neuron apoptotic process Source: Ensembl
  5. response to hypoxia Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Egl nine homolog 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EGLN2Imported
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiG2HG38.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliG2HG38.
SMRiG2HG38. Positions 176-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000001936.
InParanoidiG2HG38.
KOiK09592.
OMAiQDGGELW.
OrthoDBiEOG7TBC2W.
TreeFamiTF314595.

Family and domain databases

InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
[Graphical view]
PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
[Graphical view]
SMARTiSM00702. P4Hc. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2HG38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPCQPQPL SQALPQLPGS SSEPLEPEPG RARMGVESYL PCPLLPSYHC
60 70 80 90 100
PGVPSEASAG SGTPRATATS TTASPLRDGF GGQDGGELRP LQSEGAAALV
110 120 130 140 150
TKGCQRLAAQ GARPEAPKRK WAEDGGDAPS PSKRPWARQE NQEAEREGGM
160 170 180 190 200
SCSCSSGSGE ASAGLMEEAL PSAPERLALD YIVPCMRYYG ICVKDSFLGA
210 220 230 240 250
ALGGRVLAEV EALKRGGRLR DGQLVSQRAI PPRSIRGDQI AWVEGHEPGC
260 270 280 290 300
RSIGALMAHV DAVIRHCAGR LGSYVINGRT KAMVACYPGN GLGYVRHVDN
310 320 330 340 350
PHGDGRCITC IYYLNQNWDV KVHGGLLQIF PEGRPVVANI EPLFDRLLIF
360 370 380 390 400
WSDRRNPHEV KPAYATRYAI TVWYFDAKER AAAKDKYQLA SGQKGVQVPV

SQPPTPT
Length:407
Mass (Da):43,650
Last modified:November 15, 2011 - v1
Checksum:iF172E9B0482C9CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03119300 Genomic DNA. No translation available.
AACZ03119301 Genomic DNA. No translation available.
AK305702 mRNA. Translation: BAK62696.1.
GABC01008794 mRNA. Translation: JAA02544.1.
GABE01004764 mRNA. Translation: JAA39975.1.
RefSeqiNP_001233442.1. NM_001246513.1.

Genome annotation databases

EnsembliENSPTRT00000020431; ENSPTRP00000044177; ENSPTRG00000011010.
GeneIDi456049.
KEGGiptr:456049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03119300 Genomic DNA. No translation available.
AACZ03119301 Genomic DNA. No translation available.
AK305702 mRNA. Translation: BAK62696.1.
GABC01008794 mRNA. Translation: JAA02544.1.
GABE01004764 mRNA. Translation: JAA39975.1.
RefSeqiNP_001233442.1. NM_001246513.1.

3D structure databases

ProteinModelPortaliG2HG38.
SMRiG2HG38. Positions 176-387.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiG2HG38.

Proteomic databases

PRIDEiG2HG38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000020431; ENSPTRP00000044177; ENSPTRG00000011010.
GeneIDi456049.
KEGGiptr:456049.

Organism-specific databases

CTDi112398.

Phylogenomic databases

GeneTreeiENSGT00390000001936.
InParanoidiG2HG38.
KOiK09592.
OMAiQDGGELW.
OrthoDBiEOG7TBC2W.
TreeFamiTF314595.

Miscellaneous databases

NextBioi20837257.

Family and domain databases

InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
[Graphical view]
PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
[Graphical view]
SMARTiSM00702. P4Hc. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  3. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported and Skeletal muscleImported.

Entry informationi

Entry nameiG2HG38_PANTR
AccessioniPrimary (citable) accession number: G2HG38
Entry historyi
Integrated into UniProtKB/TrEMBL: November 15, 2011
Last sequence update: November 15, 2011
Last modified: March 31, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.