ID   G1U2Z9_RABIT            Unreviewed;       218 AA.
AC   G1U2Z9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=Small ribosomal subunit protein uS5 {ECO:0000256|ARBA:ARBA00035255};
DE   AltName: Full=40S ribosomal protein S2 {ECO:0000256|ARBA:ARBA00035407};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023756.3, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000023756.3, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0007829|PDB:4KZX, ECO:0007829|PDB:4KZY}
RP   X-RAY CRYSTALLOGRAPHY (7.01 ANGSTROMS) OF 1-227.
RX   PubMed=23873042; DOI=10.1038/nature12355;
RA   Lomakin I.B., Steitz T.A.;
RT   "The initiation of mammalian protein synthesis and mRNA scanning
RT   mechanism.";
RL   Nature 500:307-311(2013).
RN   [3] {ECO:0000313|Ensembl:ENSOCUP00000023756.3}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023756.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS5 family.
CC       {ECO:0000256|ARBA:ARBA00008945, ECO:0000256|RuleBase:RU003823}.
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DR   PDB; 4KZX; X-ray; 7.81 A; C=1-217.
DR   PDB; 4KZY; X-ray; 7.01 A; C=1-217.
DR   PDB; 4KZZ; X-ray; 7.03 A; C=1-217.
DR   PDBsum; 4KZX; -.
DR   PDBsum; 4KZY; -.
DR   PDBsum; 4KZZ; -.
DR   AlphaFoldDB; G1U2Z9; -.
DR   SMR; G1U2Z9; -.
DR   STRING; 9986.ENSOCUP00000023756; -.
DR   Ensembl; ENSOCUT00000024894.3; ENSOCUP00000023756.3; ENSOCUG00000026627.3.
DR   eggNOG; KOG0877; Eukaryota.
DR   GeneTree; ENSGT00940000154326; -.
DR   HOGENOM; CLU_065898_0_3_1; -.
DR   InParanoid; G1U2Z9; -.
DR   TreeFam; TF300806; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000026627; Expressed in uterus and 16 other cell types or tissues.
DR   GO; GO:0022626; C:cytosolic ribosome; IEA:UniProt.
DR   GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:UniProtKB-UniRule.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 3.30.160.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR000851; Ribosomal_uS5.
DR   InterPro; IPR005324; Ribosomal_uS5_C.
DR   InterPro; IPR005711; Ribosomal_uS5_euk/arc.
DR   InterPro; IPR013810; Ribosomal_uS5_N.
DR   InterPro; IPR018192; Ribosomal_uS5_N_CS.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR01020; uS5_euk_arch; 1.
DR   PANTHER; PTHR13718:SF4; 40S RIBOSOMAL PROTEIN S2; 1.
DR   PANTHER; PTHR13718; RIBOSOMAL S SUBUNIT; 1.
DR   Pfam; PF00333; Ribosomal_S5; 1.
DR   Pfam; PF03719; Ribosomal_S5_C; 1.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00585; RIBOSOMAL_S5; 1.
DR   PROSITE; PS50881; S5_DSRBD; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4KZX, ECO:0007829|PDB:4KZY};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, ECO:0000256|PROSITE-
KW   ProRule:PRU00268};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980, ECO:0000256|PROSITE-
KW   ProRule:PRU00268}.
FT   DOMAIN          44..90
FT                   /note="S5 DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50881"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   218 AA;  23166 MW;  4CE011AA008759BA CRC64;
     MADDAGAAGG PGGPGGPGMG GKAEDKEWLP GTKLGRLIID FFLGARTRFK AFMAIGDYNG
     HVSLGVKCSK EVATAIRGAI ILAKLSIVPV RRGYWGNKIG KPHTVPCKVT GRCGSVLVRL
     IPAPRGTRIV SAPVPKKLLM MAGIDDCYTS ARGCTATLGN LAKATFDAIS KTYSYLTPDL
     WKETVFTKSP YQEFTDHLVK THTRVSMQRT QAPAVATA
//