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Protein

40S ribosomal protein SA

Gene

RPSA

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation, Ribonucleoprotein, Ribosomal proteinUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein SAUniRule annotation
Alternative name(s):
37 kDa laminin receptor precursorUniRule annotation
37/67 kDa laminin receptorUniRule annotation
67 kDa laminin receptorUniRule annotation
Laminin receptor 1UniRule annotation
Laminin-binding protein precursor p40UniRule annotation
Gene namesi
Name:RPSAUniRule annotation
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 8

Subcellular locationi

  • Cell membrane UniRule annotation
  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

  • Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.UniRule annotation
  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, CytoplasmUniRule annotationSAAS annotation, Membrane, NucleusUniRule annotation

PTM / Processingi

Post-translational modificationi

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.UniRule annotation
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117 – 118Cleavage; by ST3; site 1UniRule annotation2
Sitei135 – 136Cleavage; by ST3; site 2UniRule annotation2

Interactioni

Subunit structurei

Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.UniRule annotation

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016036.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KZXX-ray7.81A14-297[»]
4KZYX-ray7.01A14-297[»]
4KZZX-ray7.03A14-297[»]
SMRiG1TGI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 29740S_SA_CInterPro annotationAdd BLAST94
Repeati232 – 234[DE]-W-[ST] 1UniRule annotation3
Repeati249 – 251[DE]-W-[ST] 2UniRule annotation3
Repeati268 – 270[DE]-W-[ST] 3UniRule annotation3
Repeati277 – 279[DE]-W-[ST] 4UniRule annotation3
Repeati295 – 297[DE]-W-[ST] 5UniRule annotation3

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 115Interaction with PPP1R16BUniRule annotationAdd BLAST60
Regioni163 – 182Laminin-bindingUniRule annotationAdd BLAST20
Regioni207 – 231Laminin-bindingUniRule annotationAdd BLAST25
Regioni244 – 297Laminin-bindingUniRule annotationAdd BLAST54

Sequence similaritiesi

Belongs to the ribosomal protein S2P family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0830. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000015036.
InParanoidiG1TGI6.
OMAiVISFCNT.
OrthoDBiEOG091G0J0Q.
TreeFamiTF300100.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_03015. Ribosomal_S2_euk. 1 hit.
MF_03016. Ribosomal_S2_laminin_receptor. 1 hit.
InterProiIPR027504. 40S_ribosomal_SA.
IPR032281. 40S_SA_C.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiPF16122. 40S_SA_C. 1 hit.
PF00318. Ribosomal_S2. 2 hits.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. uS2_euk_arch. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G1TGI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HNPGLPAQIR SKLEEDVLKF LAAGTHLGGT NLDFQMEQYI YKRKSDGIYI
60 70 80 90 100
INLKRTWEKL LLAARAIVAI ENPADVSVIS SRNTGQRAVL KFAAATGATP
110 120 130 140 150
IAGRFTPGTF TNQIQAAFRE PRLLVVTDPR ADHQPLTEAS YVNLPTIALC
160 170 180 190 200
NTDSPLRYVD IAIPCNNKGA HSVGLMWWML AREVLRMRGT ISREHPWEVM
210 220 230 240 250
PDLYFYRDPE EIEKEEQAAA EKAVTKEEFQ GEWTAPAPEF TATQPEVADW
260 270 280 290
SEGVQVPSVP IQQFPTEDWS AQPATEDWSA APTAQATEWV GTTTEWS
Length:297
Mass (Da):33,136
Last modified:October 19, 2011 - v1
Checksum:iEF920874A51CE435
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02051613 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSOCUT00000027846; ENSOCUP00000016036; ENSOCUG00000022961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02051613 Genomic DNA. No translation available.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KZXX-ray7.81A14-297[»]
4KZYX-ray7.01A14-297[»]
4KZZX-ray7.03A14-297[»]
SMRiG1TGI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000027846; ENSOCUP00000016036; ENSOCUG00000022961.

Phylogenomic databases

eggNOGiKOG0830. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000015036.
InParanoidiG1TGI6.
OMAiVISFCNT.
OrthoDBiEOG091G0J0Q.
TreeFamiTF300100.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_03015. Ribosomal_S2_euk. 1 hit.
MF_03016. Ribosomal_S2_laminin_receptor. 1 hit.
InterProiIPR027504. 40S_ribosomal_SA.
IPR032281. 40S_SA_C.
IPR001865. Ribosomal_S2.
IPR018130. Ribosomal_S2_CS.
IPR027498. Ribosomal_S2_euk.
IPR005707. Ribosomal_S2_euk/arc.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR11489. PTHR11489. 1 hit.
PfamiPF16122. 40S_SA_C. 1 hit.
PF00318. Ribosomal_S2. 2 hits.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01012. uS2_euk_arch. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG1TGI6_RABIT
AccessioniPrimary (citable) accession number: G1TGI6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 30, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.UniRule annotation

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.