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Protein

Histone-lysine N-methyltransferase

Gene

ASH1L

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:ASH1LImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSOCUG00000014986.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000012882.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2131 – 2182AWSInterPro annotationAdd BLAST52
Domaini2185 – 2301SETInterPro annotationAdd BLAST117
Domaini2309 – 2325Post-SETInterPro annotationAdd BLAST17
Domaini2503 – 2573BromoInterPro annotationAdd BLAST71
Domaini2701 – 2838BAHInterPro annotationAdd BLAST138

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1083. Eukaryota.
COG2940. LUCA.
COG5076. LUCA.
GeneTreeiENSGT00780000121845.
InParanoidiG1T8I1.
OMAiHSEMTDY.
OrthoDBiEOG091G02U7.
TreeFamiTF106416.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00384. AT_hook. 4 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.

Sequencei

Sequence statusi: Complete.

G1T8I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDTQQRQKP NGRAASPLGP SSATPSPRES PPGGAPFTGL TPHPNSELRC
60 70 80 90 100
FPVPARRLTV NRGPACLLRG PAHTVSYHRL QSASPATAKR LRWYGRKLLN
110 120 130 140 150
AQPPRPPPAG QQRGAGWPET RSARPAGGER KRAVAPRRRA QGVRLAAGRL
160 170 180 190 200
LTSGRDPLWT KGSRGAWRPP PLPHFPALSS LSASASDTDP SKLYKKAGDV
210 220 230 240 250
AAIECQSEES IHLHSQGEST PLSKKLSPVH SEMADFVNAS PSTLVGSRDP
260 270 280 290 300
DLKDRALLNG GTSVTEKLAQ LIATCPPSKS SKTKPKKLGT GTTAGLVSKD
310 320 330 340 350
LIRKAGIGSV AGIIHKDLIK KPTISTAVGL VTKDAGKKPM FNPAVGLVNK
360 370 380 390 400
DSVKKLGTGT TAVFINKDLG KKPGTITTVG LLSKDSGKKL GIGIVPGLMN
410 420 430 440 450
KESGKKLGLG TVVGLVNKDL GRKLSSTVGL VAKDCAKKIV ASSAMGLVNK
460 470 480 490 500
DIGKKLVTCP VAGLVSKDAI NLKAEALLPT QDPLKASCSA NISNHESEEL
510 520 530 540 550
SESLKDSATS RTFEKNVIRQ NKESALEKFS ARKEIINLEK EIFNEGSCIQ
560 570 580 590 600
QDSFSSSERG SYETSKHEKQ PPVYCTSPDF QMGGGSDAST AKSPFSAVGE
610 620 630 640 650
SNLPSPSPTV SVNPLTRSPP ETSSPLAPNP LLLSPTTELM EEISESVGKN
660 670 680 690 700
QFNSESTHLN VGHRSMGHSI SIECKGIDKE LNDSKTTHID IPRISSSLGK
710 720 730 740 750
KPNFTSESSI HTITPSVVNF TSLFSNKPFL KLGAVSAPDK HCQVAESLST
760 770 780 790 800
SLQSKPLKKR KGRKPRWTKV VARSTCRSPK GLELERSELF KNVSCGSLSN
810 820 830 840 850
SSSESAKFMK NIGSTSFVDH DFLKRRLPKL SKSTSPSLAL LTDGEKPSHK
860 870 880 890 900
SFATHKLSSS MCVSSDLLSD IYKPKRGRPK SKEMPQLEGP PKRTLKIPAS
910 920 930 940 950
KVFSLQSKEE QEPPILQPEI EIPSFKQSLS VSPFPKKRGR PKRQMRSPVK
960 970 980 990 1000
MKPPVLSVAP FVATESPSKL ESESENHRSS SDFFESEDQL QDPDDLDDSH
1010 1020 1030 1040 1050
RPSVCSMSDL EMEPDKKITK RNNGQLMKTI IRKINKMKTL KRKKLLNQIL
1060 1070 1080 1090 1100
SSSVESSNKG KVQSKLHNTV SSLAATFGSK LGQQINVSKK GTIYIGKRRG
1110 1120 1130 1140 1150
RKPKTVLNGI LSGSPTSLAV LEQTAQQAAG SALGQILPPL LPSSASSSEI
1160 1170 1180 1190 1200
LPSPICSQSS GTSGGQSPVS SDAGFVEPSS VPYLHLHSRQ GMIQTLAMKK
1210 1220 1230 1240 1250
ASKGRRRLSP PTLLPNSPSH LSELTSLKEA TPSPISESHS DETIPSDSGI
1260 1270 1280 1290 1300
GTDNNSTSDR AEKFCGQKKR RHSFEHVSLI PPESSTVLSG LKEKHKHKCK
1310 1320 1330 1340 1350
RRNHDYLSYD KMKRQKRKRK KKYPQLRNRQ DPDFIAELEE LISRLSEIRI
1360 1370 1380 1390 1400
THRSHHFIPR DLLPTIFRIN FNSFYTHPSF PLDPLHYIRK PDLKKKRGRP
1410 1420 1430 1440 1450
PKMREAMAEM PFMHSLSFPL SSTGFYPSYG MPYSPSPLTA APIGLGYYGR
1460 1470 1480 1490 1500
YPPTLYPPPP SPSFTTPLPP PSYMHAGHLL LNPTKYHKKK HKLLRQEAFL
1510 1520 1530 1540 1550
TTSRTPLLSM STYPSVPPEM AYGWMVEHKH RHRHKHREHR SEQPQVSMDA
1560 1570 1580 1590 1600
GSSRSVLESL KRYRFGKDTL GERYKHKEKH RCHMSCPHLS PSKSLINREE
1610 1620 1630 1640 1650
QWVHREPSES SSLALGLQTP LQIDCSESSP GLSLGGFTPN SEPASSDEHT
1660 1670 1680 1690 1700
NLFTSAIGSC RVSNPNSSGR KKLTDSPGLF AQDTTLNRPH RKEPLPSSER
1710 1720 1730 1740 1750
AVHTLTGSQS TSDKPSQRSS ESTNCSPARK RSSSESTSST VNGVPSRSPR
1760 1770 1780 1790 1800
LVASGDDSVD SLLQRMVQNE DQEPMEKNID AVIATASAAP SSSPGRSHSK
1810 1820 1830 1840 1850
ERTLGKPDSL LVPAVPIDPC SNSISLLSEK LTSSCSPHHI KRSVMEAMQR
1860 1870 1880 1890 1900
QARKMCNYDK ILATKKNLDH VNKILKAKKL QRQARTGNNF VKRRPGRPRK
1910 1920 1930 1940 1950
CPLQAVVSMQ AFQAAQFVNP ELNEGEEAAA LHLNPDTVTD VIEAVVQSVN
1960 1970 1980 1990 2000
LNPEHKKGLK RKSWFLNEQA RKKQKSLPEE EEQENNKSFT EAPVEIPSPS
2010 2020 2030 2040 2050
DTPAKPPEPE SNLQPVLSLI PREKKAPRPP KKKYQKAGLY SDVYKTTDPK
2060 2070 2080 2090 2100
SRLIQLKKEK LEYTPGEHEY GLFPAPIHVG KYLRQKRIDF QLPYDILWQW
2110 2120 2130 2140 2150
KHNQLYKKPD VPLYKKIRSN VYVDVKPLSG YEATTCNCKK PDDDTRKGCV
2160 2170 2180 2190 2200
DDCLNRMIFA ECSPNTCPCG DQCCNQRIQR HEWVQCLERF RAEEKGWGIR
2210 2220 2230 2240 2250
TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID
2260 2270 2280 2290 2300
SYRMGNEARF INHSCDPNCE MQKWSVNGVY RIGLYALKDM PAGTELTYDY
2310 2320 2330 2340 2350
NFHSFNVEKQ QLCKCGFEKC RGIIGGKSQR MNGLASGKSN QPITTHKKSG
2360 2370 2380 2390 2400
RSKEKRKSKH KLKKRKGHFS EETNENINTP TRLTPQLQMK PMSNRERNFV
2410 2420 2430 2440 2450
LKHHVFLVRN WEKIRQKQEE VKHTSDNIHS ASLYTRWNGI CRDDGNIKSD
2460 2470 2480 2490 2500
VFMTQFSALQ TARSVRTRRL AAAEENIEVA RAARLAQIFK EICDGIISYK
2510 2520 2530 2540 2550
DSSRQALAAP LLNLPPKKKN ADYYEKISDP LDLITIEKQI LTGYYKTVEA
2560 2570 2580 2590 2600
FDADMLKVFR NAEKYYGRKS PIGRDVCRLR KAYYNARHEA SAQIDEIVGE
2610 2620 2630 2640 2650
TASEADSSET SVSEKENGHE KDDDVIRCIC GLYKDEGLMI QCDKCMVWQH
2660 2670 2680 2690 2700
CDCMGVNSDV EHYLCEQCDP RPVDREVPMI PRPHYAQPGC VYFICLLRDD
2710 2720 2730 2740 2750
LLLRQGDCVY LMRDSRRTPD GHPVRQSYRL LSHINRDKLD IFRIEKLWKN
2760 2770 2780 2790 2800
EKDERFAFGH HYFRPHETHH SPSRRFYHNE LFRVPLYEII PLEAVVGTCC
2810 2820 2830 2840 2850
VLDLYTYCKG RPKGVKEQDV YICDYRLDKS AHLFYKIHRN RYPVCTKPYA
2860 2870 2880 2890 2900
FDHFPKKLTP KRDFSPHYVP DNYKRNGGRS SWKSERSKPP LKDLGQEDDA
2910 2920 2930 2940 2950
LPLIEEVLAS QEQAANEMHS MEEPEQEGAT AQVSEGEKNT EESSQEPQPA
2960 2970 2980 2990 3000
CTPEERRHNQ RERLNQILLN LLEKIPGKNA IDVTYLLEEG SGRKLRRRTL

FIPENSFRK
Length:3,009
Mass (Da):336,111
Last modified:November 13, 2013 - v2
Checksum:i16BAC2B6809BA3F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02000434 Genomic DNA. No translation available.
AAGW02000435 Genomic DNA. No translation available.
AAGW02000436 Genomic DNA. No translation available.
AAGW02000437 Genomic DNA. No translation available.
AAGW02000438 Genomic DNA. No translation available.
AAGW02000439 Genomic DNA. No translation available.
AAGW02000440 Genomic DNA. No translation available.
AAGW02000441 Genomic DNA. No translation available.
AAGW02000442 Genomic DNA. No translation available.
AAGW02000443 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSOCUT00000014991; ENSOCUP00000012882; ENSOCUG00000014986.

Similar proteinsi

Entry informationi

Entry nameiG1T8I1_RABIT
AccessioniPrimary (citable) accession number: G1T8I1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: October 25, 2017
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported