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Protein

Phospholipase A(2)

Gene

PLA2G2E

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.UniRule annotation

Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processLipid metabolismUniRule annotation
LigandCalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A(2)UniRule annotation (EC:3.1.1.4UniRule annotation)
Gene namesi
Name:PLA2G2EImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_500139050220 – 142Phospholipase A(2)UniRule annotationAdd BLAST123

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005681

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 136PA2cInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the phospholipase A2 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
InParanoidiG1SR98
KOiK01047
OMAiLQYNDYG
OrthoDBiEOG091G0UZ3
TreeFamiTF319283

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

G1SR98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPPVLTRL CLLVALVGGN LVQFGVMIER VTGKSALQYN DYGCYCGIGG
60 70 80 90 100
SHWPVDPTDW CCHAHDCCYG RVEKLGCEPK LEKYFFSASK HGVFCAGRTT
110 120 130 140
CQRETCECDK RAALCFRHNL GSYDRKYANY PNRLCTGPTP PC
Length:142
Mass (Da):15,837
Last modified:November 13, 2013 - v2
Checksum:i76A936F622480EDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02059958 Genomic DNA No translation available.
RefSeqiXP_002716050.1, XM_002716004.3

Genome annotation databases

EnsembliENSOCUT00000006573; ENSOCUP00000005681; ENSOCUG00000006574
GeneIDi100351928
KEGGiocu:100351928

Similar proteinsi

Entry informationi

Entry nameiG1SR98_RABIT
AccessioniPrimary (citable) accession number: G1SR98
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: March 28, 2018
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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