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Protein
Submitted name:

Glucagon like peptide 1 receptor

Gene

GLP1R

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Glucagon like peptide 1 receptorImported
Gene namesi
Name:GLP1RImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 167HelicalSequence analysisAdd BLAST23
Transmembranei179 – 196HelicalSequence analysisAdd BLAST18
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei268 – 287HelicalSequence analysisAdd BLAST20
Transmembranei307 – 332HelicalSequence analysisAdd BLAST26
Transmembranei353 – 371HelicalSequence analysisAdd BLAST19
Transmembranei391 – 409HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500342206024 – 462Sequence analysisAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71Combined sources
Disulfide bondi62 ↔ 104Combined sources
Disulfide bondi85 ↔ 126Combined sources
Disulfide bondi226 ↔ 296Combined sources

Expressioni

Gene expression databases

BgeeiENSOCUG00000001898.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001636.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VAIelectron microscopy4.10R24-422[»]
ProteinModelPortaliG1SGD4.
SMRiG1SGD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 130G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST86
Domaini144 – 406G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST263

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
InParanoidiG1SGD4.
KOiK04581.
OMAiRNSNMNY.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Family and domain databases

CDDicd15268. 7tmB1_GLP1R. 1 hit.
Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR036445. GPCR_2_extracell_dom_sf.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PANTHERiPTHR12011:SF245. PTHR12011:SF245. 1 hit.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

G1SGD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAPSPLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRRQCQHFL
60 70 80 90 100
TEAPPLATGL FCNRTFDDYA CWPDGAPGSF VNVSCPWYLP WASNVLQGHV
110 120 130 140 150
YRFCTTEGHW LHKDNSSLPW RDLSECEESR RGEKSSPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGAY
260 270 280 290 300
LYTLLAFAVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ MEFRKSWERW RLEHLRVQRD SSMKPLKCPT SSLSSGATGG
460
SSVYAATSQA CS
Length:462
Mass (Da):52,599
Last modified:November 13, 2013 - v2
Checksum:i2F578AC6ECF78A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02017893 Genomic DNA. No translation available.
AAGW02017894 Genomic DNA. No translation available.
RefSeqiXP_002714738.1. XM_002714692.3.

Genome annotation databases

EnsembliENSOCUT00000001897; ENSOCUP00000001636; ENSOCUG00000001898.
GeneIDi100356720.
KEGGiocu:100356720.

Similar proteinsi

Entry informationi

Entry nameiG1SGD4_RABIT
AccessioniPrimary (citable) accession number: G1SGD4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: November 13, 2013
Last modified: November 22, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported