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Protein

Glucosylceramidase

Gene

GBA

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
Biological processLipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
Gene namesi
Name:GBAImported
OrganismiOryctolagus cuniculus (Rabbit)Imported
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_500342170540 – 537GlucosylceramidaseSequence analysisAdd BLAST498

Expressioni

Gene expression databases

BgeeiENSOCUG00000000356

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000316

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 466Glyco_hydro_30InterPro annotationAdd BLAST350
Domaini470 – 532Glyco_hydro_30CInterPro annotationAdd BLAST63

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2566 Eukaryota
COG5520 LUCA
GeneTreeiENSGT00390000009464
InParanoidiG1SD48
OMAiTYCDSLD
OrthoDBiEOG091G06I4
TreeFamiTF314254

Family and domain databases

Gene3Di2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR033452 GH30_C
IPR001139 Glyco_hydro_30
IPR033453 Glyco_hydro_30_TIM-barrel
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11069 PTHR11069, 1 hit
PfamiView protein in Pfam
PF02055 Glyco_hydro_30, 1 hit
PF17189 Glyco_hydro_30C, 1 hit
PRINTSiPR00843 GLHYDRLASE30
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

G1SD48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPRHSGEE CSKHQGRVAM MAASLTGLLL LQAVSWASGA RPCIAKSFGY
60 70 80 90 100
SSVVCVCNAT YCDSLDPLTL PALGTFSRYE STRSGRRMEL STGTFQANRT
110 120 130 140 150
GTGLLLTLQP EEKFQKIKGF GGAMTDAAAL NILALSPAAQ DLLLKSYFSK
160 170 180 190 200
EGIEYNIIRV PMASCDFSIR VYTYADTPDD FLLQNFSLPE EDTKLKIPLI
210 220 230 240 250
HRALQMAQRP VSLFASPWTS PTWLKTNGAV NGKGSIKGQP GDLYHQIWAR
260 270 280 290 300
YFVKFLDAYA EHKLQFWAVT AENEPSAGLI SGYPFQCLGF TPEHQRDFIA
310 320 330 340 350
RDLGPALANS THRDVRLLIL DDQRLLLPYW AQVVLTDPEA AKYVHGIAVH
360 370 380 390 400
WYLDFLAPAK ATLGATHRLF PNTTLFASEA CVGSKFWEQS VRLGSWDRGT
410 420 430 440 450
QYSHSIITNL LYHVVGWTDW NLALNPEGGP NWVRNFVDSP IIVDIAKDTF
460 470 480 490 500
YKQPMFYHLG HFSSKFIPEG SQRVGLLASA KNNLDTVALM RPDGSAVVVV
510 520 530
LNRSSKDVPL TIEDPAMGFL ETISPGYSIH TYLWRRQ
Length:537
Mass (Da):59,756
Last modified:October 19, 2011 - v1
Checksum:i60B2518E3B1EEDC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02000452 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSOCUT00000000357; ENSOCUP00000000316; ENSOCUG00000000356

Similar proteinsi

Entry informationi

Entry nameiG1SD48_RABIT
AccessioniPrimary (citable) accession number: G1SD48
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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