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Protein

Cytochrome P450

Gene

CYP1A2

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:CYP1A2Imported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, MicrosomeUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000017767.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00900000140831.
InParanoidiG1RWZ0.
OMAiYTNGLNM.
OrthoDBiEOG091G0BT8.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

G1RWZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NPANLEHLPL QLVQMALSQS VPFSATELLL ASAIFCLVFW VLKGSRPRVP
60 70 80 90 100
KGLKSPPEPW GWPLLGHVLT LRKNPHLALS KMSQRYGDVL QIRIGSTPVL
110 120 130 140 150
VLSGLDTIRQ ALVRQGDDFK GRPDLYSSTF ITDGHSMSFS PDSGPVWAAR
160 170 180 190 200
RRLAQNALNA FSIASDPASS SSCYLEEHVS KEAEALISRL QELMAGPGHF
210 220 230 240 250
DPYNQVVVSV ANVIGAMCFG QHFPESSDEM LSLVKNTHEF VEVASSGNPV
260 270 280 290 300
DFFPILRYLP NPALQRFKAF NQRFLRFLQK TVQEHYQDFD KNSVQDITGA
310 320 330 340 350
LFKYSKKGPR ASGDLIPQEK IVNLVNDIFG AGFDTVTTAI SWSLMYLVTK
360 370 380 390 400
PEIQRKIQKE LDTVIGRGRR PRLSDRPQLP YLEAFILETF RHSSFLPFTI
410 420 430 440 450
PHSTTRDTTL NGFYIPKECC VFVNQWQVNH DPELWEDPSE FRPERFLTAD
460 470 480 490 500
GTAIYKPLSE KMMLFGMGKR RCIGEVLAKW EVFLFLAILL QQLEFSVPPG
510 520 530
VKVDLTPIYG LTMKHARCEH VQARLRFSIK
Length:530
Mass (Da):59,852
Last modified:May 1, 2013 - v2
Checksum:i7F6B7AC8CEB21490
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01036521 Genomic DNA. No translation available.
ADFV01036522 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSNLET00000018654; ENSNLEP00000017767; ENSNLEG00000014596.

Similar proteinsi

Entry informationi

Entry nameiG1RWZ0_NOMLE
AccessioniPrimary (citable) accession number: G1RWZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: May 1, 2013
Last modified: October 25, 2017
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported