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Protein
Submitted name:

Estrogen receptor 2

Gene

ESR2

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 221Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor 2Imported
Gene namesi
Name:ESR2Imported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Chromosome 1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000017213

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 221Nuclear receptorInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
InParanoidiG1RVD6
KOiK08551
OMAiEPQKSPW
OrthoDBiEOG091G03V4
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR028355 ER-beta/gamma
IPR021064 Estrogen_rcpt_beta_N
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12497 ERbeta_N, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500102 ER-b, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

G1RVD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVESH HEYPAITFYS
60 70 80 90 100
PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PAPGHLSPLA VHRQLSHLYA
110 120 130 140 150
EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCTSPVTGP SSKRDAHFCA
160 170 180 190 200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS
210 220 230 240 250
CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKTKRSGG
260 270 280 290 300
HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK
310 320 330 340 350
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWLEVLM VGLMWRSIDH
360 370 380 390 400
PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV
410 420 430 440 450
KAMILLNSSM YPLVAATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ
460 470 480 490 500
QSMRLANLLM LLSHVRHASN KGMEHLLSMK CKNVVPVYEL LLEMLNAHVL
510 520 530
RGCKSSITGS ECSLAEDSKS KEGSQNPQSQ
Length:530
Mass (Da):59,167
Last modified:October 19, 2011 - v1
Checksum:i4DA0508CDED4B2BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01040835 Genomic DNA No translation available.
ADFV01040836 Genomic DNA No translation available.
ADFV01040837 Genomic DNA No translation available.
ADFV01040838 Genomic DNA No translation available.
ADFV01040839 Genomic DNA No translation available.
ADFV01040840 Genomic DNA No translation available.
ADFV01040841 Genomic DNA No translation available.
ADFV01040842 Genomic DNA No translation available.
ADFV01040843 Genomic DNA No translation available.
ADFV01040844 Genomic DNA No translation available.
RefSeqiXP_003267842.1, XM_003267794.1
XP_012359897.1, XM_012504443.1

Genome annotation databases

EnsembliENSNLET00000018076; ENSNLEP00000017213; ENSNLEG00000014123
GeneIDi100595169
KEGGinle:100595169

Similar proteinsi

Entry informationi

Entry nameiG1RVD6_NOMLE
AccessioniPrimary (citable) accession number: G1RVD6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health