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Protein
Submitted name:

Adhesion G protein-coupled receptor L2

Gene

ADGRL2

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor L2Imported
Gene namesi
Name:ADGRL2Imported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei832 – 857HelicalSequence analysisAdd BLAST26
Transmembranei869 – 887HelicalSequence analysisAdd BLAST19
Transmembranei893 – 917HelicalSequence analysisAdd BLAST25
Transmembranei938 – 958HelicalSequence analysisAdd BLAST21
Transmembranei978 – 1001HelicalSequence analysisAdd BLAST24
Transmembranei1022 – 1045HelicalSequence analysisAdd BLAST24
Transmembranei1051 – 1074HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501412440526 – 1403Sequence analysisAdd BLAST1378

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Interactioni

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000012007.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 130SUEL-type lectinInterPro annotationAdd BLAST90
Domaini135 – 394Olfactomedin-likeInterPro annotationAdd BLAST260
Domaini468 – 525G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST58
Domaini772 – 823GPSInterPro annotationAdd BLAST52
Domaini834 – 1075G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00900000140800.
InParanoidiG1RFK7.
OMAiYFNANCS.
OrthoDBiEOG091G00GJ.
TreeFamiTF351999.

Family and domain databases

Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR036445. GPCR_2_extracell_dom_sf.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR031240. Latrophilin-2.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
PANTHERiPTHR12011:SF61. PTHR12011:SF61. 1 hit.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 2 hits.
PF02191. OLF. 1 hit.
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiView protein in SMART
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

G1RFK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSGCRMRS LWFIIVISFL PNSEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCIVITGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY
160 170 180 190 200
EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT
210 220 230 240 250
YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY
260 270 280 290 300
HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA
310 320 330 340 350
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR
360 370 380 390 400
GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV
410 420 430 440 450
PTTAVTITSS AELFKTTVST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV
460 470 480 490 500
STTKIPPVTN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA
510 520 530 540 550
SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT
560 570 580 590 600
KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKAIVDTV
610 620 630 640 650
DNLLRPEALE SWKHMNSSEQ AHTATMLLDT LEEGAFVLAD NLLEPTRVSM
660 670 680 690 700
PTENIVLEVA VLSTEGQIQD FKFPLGIKGA GSSIQLSANT VKQNSRNGLA
710 720 730 740 750
KLVFIIYRSL GQFLSTENAT IKLGADFIGR NSTIAVNSHV ISVSINKESS
760 770 780 790 800
RVYLTDPVLF TLPHIDPDNY FNANCSFWNY SERTMMGYWS TQGCKLVDTN
810 820 830 840 850
KTRTTCACSH LTNFAILMAH REIAYKDGVH ELLLTVITWV GIVISLVCLA
860 870 880 890 900
ICIFTFCFFR GLQSDRNTIH KNLCINLFIA EFIFLIGIDK TKYAIACPIF
910 920 930 940 950
AGLLHFFFLA AFAWMCLEGV QLYLMLVEVF ESEYSRKKYY YVAGYLFPAT
960 970 980 990 1000
VVGVSAAIDY KSYGTEKACW LHVDNYFIWS FIGPVTFIIL LNIIFLVITL
1010 1020 1030 1040 1050
CKMVKHSNTL KPDSSRLENI KSWVLGAFAL LCLLGLTWSF GLLFINEETI
1060 1070 1080 1090 1100
VMAYLFTIFN AFQGVFIFIF HCALQKKVRK EYGKCFRHSY CCGGLPTESP
1110 1120 1130 1140 1150
HSSVKASTTR TSARYSSGTQ SRIRRMWNDT VRKQSESSFI SGDINSTSTL
1160 1170 1180 1190 1200
NQGHSLNNAR DTSAMDTLPL NGNFNNSYSL RKGDYNDSVQ VVDCGLSLND
1210 1220 1230 1240 1250
TAFEKMIISE LVHNNLRGSS KTHNLELTLP VKPVIGGSSS EDDAIVADAS
1260 1270 1280 1290 1300
SLMHSDNPGL ELHHKELKAP LIPQRTHSLL YQPQKKVKSE GTDSYVSQLT
1310 1320 1330 1340 1350
AEGEDHLQSP NRDSLYTSMP NLRDSPYPES SPDMEEDLSP SRRSENEDIY
1360 1370 1380 1390 1400
YKSMPNLGAG HQLQMCYQIS RGNSDGYIIP INKEGCIPEG DVREGQMQLV

TSL
Length:1,403
Mass (Da):157,142
Last modified:February 28, 2018 - v2
Checksum:iA7946B12F544D14C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01189289 Genomic DNA. No translation available.
ADFV01189290 Genomic DNA. No translation available.
ADFV01189291 Genomic DNA. No translation available.
ADFV01189292 Genomic DNA. No translation available.
ADFV01189293 Genomic DNA. No translation available.
ADFV01189294 Genomic DNA. No translation available.
RefSeqiXP_003260290.1. XM_003260242.2.

Genome annotation databases

EnsembliENSNLET00000012592; ENSNLEP00000012007; ENSNLEG00000009826.
GeneIDi100581898.

Similar proteinsi

Entry informationi

Entry nameiG1RFK7_NOMLE
AccessioniPrimary (citable) accession number: G1RFK7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: February 28, 2018
Last modified: March 28, 2018
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported