Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mast/stem cell growth factor receptor

Gene

KIT

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi569MagnesiumUniRule annotation1
Binding sitei624ATPUniRule annotation1
Binding sitei789ATPUniRule annotation1
Metal bindingi790MagnesiumUniRule annotation1
Metal bindingi803MagnesiumUniRule annotation1
Sitei929Important for interaction with phosphotyrosine-binding proteinsUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi597 – 604ATPUniRule annotation8
Nucleotide bindingi672 – 678ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mast/stem cell growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:KITImported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei522 – 544HelicalUniRule annotationAdd BLAST23
Transmembranei708 – 729HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501398917026 – 969Mast/stem cell growth factor receptorUniRule annotationAdd BLAST944

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000010174

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 108Ig-likeInterPro annotationAdd BLAST72
Domaini212 – 309Ig-likeInterPro annotationAdd BLAST98
Domaini590 – 930Protein kinaseInterPro annotationAdd BLAST341

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
InParanoidiG1RAC7
KOiK05091
OMAiPTFKQIV
OrthoDBiEOG091G01TL
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR027263 SCGF_receptor
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF500951 SCGF_recepter, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequencei

Sequence statusi: Complete.

G1RAC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PAKSELIVRV
60 70 80 90 100
GDEIRLLCTD PGFVKWTFEI LDETNENKQN EWIREKAEAT NTGKYTCTNK
110 120 130 140 150
HGLSSSIYVF VRDPAKLFLV DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG
160 170 180 190 200
CQGKPLPKDL RFVPDPKAGI MIKSVKRTYH RLCLHCSVDQ EGKSVLSEKF
210 220 230 240 250
ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS SVYSTWKREN
260 270 280 290 300
SQQTKLQEKY NSWHHGDFNY ERQATLTISS ARVNDSGVFM CYANNTFGSA
310 320 330 340 350
NVTTALEVVD KGFINIFPMI NTTVFVNDGE NVDLIVEYEA FPKPEHQQWI
360 370 380 390 400
YMNRTFTDKW EDYPKSENES NIRYVSELHL TRLKGTEGGT YTFLVSNSDV
410 420 430 440 450
SASIAFNVYV NTKPEILTYD RLVNGMLQCV AAGFPEPTID WYFCPGTEQR
460 470 480 490 500
CSASVLPVDV QTLNSSGPPF GKLVVQSSID SSAFKHNGTV ECKAYNDVGK
510 520 530 540 550
TSAYFNFAFK GNNKEQIHPH TLFTPLLIGF VIVAGMMCII VMILTYKYLQ
560 570 580 590 600
KPMYEVQWKV VEEINGNNYV YIDPTQLPYD HKWEFPRNRL SFGKTLGAGA
610 620 630 640 650
FGKVVEATAY GLIKSDAAMT VAVKMLKPSA HLTEREALMS ELKVLSYLGN
660 670 680 690 700
HMNIVNLLGA CTIGGPTLVI TEYCCYGDLL NFLRRKRDSF ICSKQEDHAE
710 720 730 740 750
AFTLLHSLPA FCMSLPLSFP FLTFMVFIAK KNPLFLTGSY IERDVTPAIM
760 770 780 790 800
EDDELALDLE DLLSFSYQVA KGMAFLASKN CIHRDLAARN ILLTHGRITK
810 820 830 840 850
ICDFGLARDI KNDSNYVVKG NARLPVKWMA PESIFNCVYT FESDVWSYGI
860 870 880 890 900
FLWELFSLGS SPYPGMPVDS KFYKMIKEGF RMLSPEHAPA EMYDIMKTCW
910 920 930 940 950
DADPLKRPTF KQIVQLIEKQ ISESTNHIYS NLANCSPNRQ KPVVDHSVRI
960
NSVGSTASSS QPLLVHDDV
Length:969
Mass (Da):109,152
Last modified:February 28, 2018 - v3
Checksum:iDC8C38EACE3E6245
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01043589 Genomic DNA No translation available.
ADFV01043590 Genomic DNA No translation available.
ADFV01043591 Genomic DNA No translation available.
ADFV01043592 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSNLET00000010675; ENSNLEP00000010174; ENSNLEG00000008295
KEGGinle:100603893

Similar proteinsi

Entry informationi

Entry nameiG1RAC7_NOMLE
AccessioniPrimary (citable) accession number: G1RAC7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 57 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health