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Protein

Tyrosine-protein kinase receptor

Gene

NTRK2

Organism
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:NTRK2Imported
OrganismiNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)Imported
Taxonomic identifieri61853 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeNomascus
Proteomesi
  • UP000001073 Componenti: Chromosome 1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei431 – 454HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_500341897832 – 838Tyrosine-protein kinase receptorSequence analysisAdd BLAST807

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi61853.ENSNLEP00000004512

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 282Ig-likeInterPro annotationAdd BLAST86
Domaini554 – 823Protein kinaseInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
InParanoidiG1QU92
KOiK04360
OMAiCSCEIMW
OrthoDBiEOG091G01JY
TreeFamiTF106465

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

G1QU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSWIRWHGP AMARLWGFCW LAVGFWRAAF ACPTSCKCSA SRIWCIDPSP
60 70 80 90 100
GIVAFPRLEP NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD
110 120 130 140 150
SGLKFVAHKA FLKNSNLQHI NFTRNKLTSL SRKHFRHLDL SELILVGNPF
160 170 180 190 200
TCSCDIMWIK TLQEAKSSPD TQDLYCLNES SKNIPLANLQ IPNCGLPSAN
210 220 230 240 250
LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM NETSHTQGSL
260 270 280 290 300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
310 320 330 340 350
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN
360 370 380 390 400
PTHMNNGDYT LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY
410 420 430 440 450
GTAANDIGDT TNRSNEIPST DVTDKTGREH LSVYAVVVIA SVVGFCLLVM
460 470 480 490 500
LFLLKLARHS KFGMKDFSWF GFGKVKSRQG VGPASVISND DDSASPLHHI
510 520 530 540 550
SNGSNTPSSS EGGPDAVIIG MTKIPVIENP QYFGITNSQL KPDTFVQHIK
560 570 580 590 600
RHNIVLKREL GEGAFGKVFL AECYNLCPEQ DKILVAVKTL KDASDNARKD
610 620 630 640 650
FHREAELLTN LQHEHIVKFY GVCVEGDPLI MVFEYMKHGD LNKFLRAHGP
660 670 680 690 700
DAVLMAEGNP PTELTQSQML HIAQQIAAGM VYLASQHFVH RDLATRNCLV
710 720 730 740 750
GENLLVKIGD FGMSRDVYST DYYRVGGHTM LPIRWMPPES IMYRKFTTES
760 770 780 790 800
DVWSLGVVLW EIFTYGKQPW YQLSNNEVIE CITQGRVLQR PRTCPQEVYE
810 820 830
LMLGCWQREP HMRKNIKGIH TLLQNLAKAS PVYLDILG
Length:838
Mass (Da):93,824
Last modified:October 19, 2011 - v1
Checksum:i38AC728BB706D427
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADFV01038526 Genomic DNA No translation available.
ADFV01038527 Genomic DNA No translation available.
ADFV01038528 Genomic DNA No translation available.
ADFV01038529 Genomic DNA No translation available.
ADFV01038530 Genomic DNA No translation available.
ADFV01038531 Genomic DNA No translation available.
ADFV01038532 Genomic DNA No translation available.
ADFV01038533 Genomic DNA No translation available.
ADFV01038534 Genomic DNA No translation available.
ADFV01038535 Genomic DNA No translation available.
RefSeqiXP_003267526.1, XM_003267478.3

Genome annotation databases

EnsembliENSNLET00000004749; ENSNLEP00000004512; ENSNLEG00000003678
GeneIDi100605330
KEGGinle:100605330

Similar proteinsi

Entry informationi

Entry nameiG1QU92_NOMLE
AccessioniPrimary (citable) accession number: G1QU92
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health