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G1NR93 (G1NR93_MELGA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMGAP00000016474

Ontologies

Keywords
   Biological processDNA damage
DNA recombination RuleBase RU000617
DNA repair RuleBase RU000617
DNA replication RuleBase RU000617
   LigandATP-binding RuleBase RU000617
Nucleotide-binding
   Molecular functionLigase RuleBase RU000617
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA ligation involved in DNA recombination

Inferred from electronic annotation. Source: Ensembl

DNA ligation involved in DNA repair

Inferred from electronic annotation. Source: Ensembl

DNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

T cell receptor V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Inferred from electronic annotation. Source: Ensembl

chromosome organization

Inferred from electronic annotation. Source: Ensembl

double-strand break repair via nonhomologous end joining

Inferred from electronic annotation. Source: Ensembl

immunoglobulin V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

isotype switching

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair, DNA gap filling

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

pro-B cell differentiation

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

single strand break repair

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentDNA ligase IV complex

Inferred from electronic annotation. Source: Ensembl

DNA-dependent protein kinase-DNA ligase 4 complex

Inferred from electronic annotation. Source: Ensembl

condensed chromosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

focal adhesion

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: Ensembl

DNA ligase (ATP) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
G1NR93 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 3C27F093A84A20D1

FASTA912104,286
        10         20         30         40         50         60 
MASAPASQLS PKRTVASHVP FADLCSTLER IQKCKSRPEK TKYFKDFLDS WRKFHSALHQ 

        70         80         90        100        110        120 
KEKDVTDSFY PAMRLILPQL ERERMAYGIK ETMLAKLYIE LLNLPKDGKD AVKLLNYRTP 

       130        140        150        160        170        180 
TGSRGDAGDF AMIAYFVLKP RSPKRGRLTV EQVNELLDAI ANNNAAKNKG LVKKSLLQLI 

       190        200        210        220        230        240 
TQSTALEQKW LIRMIIKDLK LGVSQQTIFS IFHPDAAELH NVTTDLEKVC RQLHDPSVSL 

       250        260        270        280        290        300 
SDVSIMLFSA FKPMLAAIAD VQQIEKQMNN QVFYIETKLD GERMQMHKDG DVYKYFSRNG 

       310        320        330        340        350        360 
FDYTQQFGAS PLDGSLTPFI HNVFKNDIQN CILDGEMMAY NPETQTFMQK GNKFDIKRMV 

       370        380        390        400        410        420 
EDSDLQTCFC VFDVLMINDQ KLGHESLSKR YKILNNVFTP VTGRIHVVHK KSARTRKEVI 

       430        440        450        460        470        480 
DALNEAIDNR EEGIMIKDPM STYKPDKRGE GWLKIKPEYV NGLMDELDLL IVGGYWGKGS 

       490        500        510        520        530        540 
RGGMMSHFLC AIAETPAPNE KPTAFHSICR VGSGYTMKEL YDLGLKLAKH WKPYNRKDPP 

       550        560        570        580        590        600 
CNILCGTEKP EMYIEPCNSV IVQIKAAEIV DSDMYKTDCT LRFPRIEKIR EDKEWYECMT 

       610        620        630        640        650        660 
LDMLEHLRSR AEGKLASKHL YIDEYDEPQE KKRRTVPKVK KVIGIAEQFK APDLSNVNKV 

       670        680        690        700        710        720 
SSVFEDVEFC VMTGTGRYSK SELESKIAEC GGSVVQNPGP DTYCVIVGAE NVRVKNIIAS 

       730        740        750        760        770        780 
NKYDVVKAEW LLQCFQSKML VPWQPAFMIH MSPDTKEHFA REYDCYGDSY TADTDVAQLK 

       790        800        810        820        830        840 
EVFSRVKDNK RMPLDLIAEL EERYSWNSCQ LCIFRGNTIY VDYYATINKP STKIHGTRLS 

       850        860        870        880        890        900 
VRALELRFYG AKVVPLLEEG VSHVVIGEDH SRVKEVKALR RMFGKKFKIV SELWVTVSIK 

       910 
EGAPKNENQF LI 

« Hide

Cross-references

Sequence databases

RefSeqXP_003203267.1. XM_003203219.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMGAT00000017448; ENSMGAP00000016474; ENSMGAG00000015532.
GeneID100551140.
KEGGmgp:100551140.

Phylogenomic databases

GeneTreeENSGT00750000117695.
KOK10777.
OMAHMCPSTK.
OrthoDBEOG7BKCT2.
TreeFamTF312980.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG1NR93_MELGA
AccessionPrimary (citable) accession number: G1NR93
Entry history
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)