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Protein

DNA ligase

Gene

LIG4

Organism
Meleagris gallopavo (Wild turkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG4Imported
OrganismiMeleagris gallopavo (Wild turkey)Imported
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000016474

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 494DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini659 – 748BRCTInterPro annotationAdd BLAST90
Domaini813 – 912BRCTInterPro annotationAdd BLAST100

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0966 Eukaryota
COG1793 LUCA
GeneTreeiENSGT00860000133881
InParanoidiG1NR93
KOiK10777
OMAiHMCPSTK
OrthoDBiEOG091G03K0
TreeFamiTF312980

Family and domain databases

CDDicd00027 BRCT, 2 hits
Gene3Di1.10.3260.10, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR021536 DNA_ligase_IV_dom
IPR036599 DNA_ligase_N_sf
IPR029710 LIG4
IPR012340 NA-bd_OB-fold
PANTHERiPTHR10459:SF7 PTHR10459:SF7, 1 hit
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF11411 DNA_ligase_IV, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 2 hits
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 2 hits
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 2 hits
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

G1NR93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAPASQLS PKRTVASHVP FADLCSTLER IQKCKSRPEK TKYFKDFLDS
60 70 80 90 100
WRKFHSALHQ KEKDVTDSFY PAMRLILPQL ERERMAYGIK ETMLAKLYIE
110 120 130 140 150
LLNLPKDGKD AVKLLNYRTP TGSRGDAGDF AMIAYFVLKP RSPKRGRLTV
160 170 180 190 200
EQVNELLDAI ANNNAAKNKG LVKKSLLQLI TQSTALEQKW LIRMIIKDLK
210 220 230 240 250
LGVSQQTIFS IFHPDAAELH NVTTDLEKVC RQLHDPSVSL SDVSIMLFSA
260 270 280 290 300
FKPMLAAIAD VQQIEKQMNN QVFYIETKLD GERMQMHKDG DVYKYFSRNG
310 320 330 340 350
FDYTQQFGAS PLDGSLTPFI HNVFKNDIQN CILDGEMMAY NPETQTFMQK
360 370 380 390 400
GNKFDIKRMV EDSDLQTCFC VFDVLMINDQ KLGHESLSKR YKILNNVFTP
410 420 430 440 450
VTGRIHVVHK KSARTRKEVI DALNEAIDNR EEGIMIKDPM STYKPDKRGE
460 470 480 490 500
GWLKIKPEYV NGLMDELDLL IVGGYWGKGS RGGMMSHFLC AIAETPAPNE
510 520 530 540 550
KPTAFHSICR VGSGYTMKEL YDLGLKLAKH WKPYNRKDPP CNILCGTEKP
560 570 580 590 600
EMYIEPCNSV IVQIKAAEIV DSDMYKTDCT LRFPRIEKIR EDKEWYECMT
610 620 630 640 650
LDMLEHLRSR AEGKLASKHL YIDEYDEPQE KKRRTVPKVK KVIGIAEQFK
660 670 680 690 700
APDLSNVNKV SSVFEDVEFC VMTGTGRYSK SELESKIAEC GGSVVQNPGP
710 720 730 740 750
DTYCVIVGAE NVRVKNIIAS NKYDVVKAEW LLQCFQSKML VPWQPAFMIH
760 770 780 790 800
MSPDTKEHFA REYDCYGDSY TADTDVAQLK EVFSRVKDNK RMPLDLIAEL
810 820 830 840 850
EERYSWNSCQ LCIFRGNTIY VDYYATINKP STKIHGTRLS VRALELRFYG
860 870 880 890 900
AKVVPLLEEG VSHVVIGEDH SRVKEVKALR RMFGKKFKIV SELWVTVSIK
910
EGAPKNENQF LI
Length:912
Mass (Da):104,286
Last modified:October 19, 2011 - v1
Checksum:i3C27F093A84A20D1
GO

Sequence databases

RefSeqiXP_003203267.1, XM_003203219.3
XP_010726898.1, XM_010728596.2
XP_010726899.1, XM_010728597.2

Genome annotation databases

EnsembliENSMGAT00000017448; ENSMGAP00000016474; ENSMGAG00000015532
GeneIDi100551140
KEGGimgp:100551140

Similar proteinsi

Entry informationi

Entry nameiG1NR93_MELGA
AccessioniPrimary (citable) accession number: G1NR93
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health