Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G1NR93

- G1NR93_MELGA

UniProt

G1NR93 - G1NR93_MELGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA ligase

Gene

LIG4

Organism
Meleagris gallopavo (Common turkey)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. central nervous system development Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA biosynthetic process Source: InterPro
  5. DNA ligation involved in DNA recombination Source: Ensembl
  6. DNA ligation involved in DNA repair Source: Ensembl
  7. DNA replication Source: UniProtKB-KW
  8. double-strand break repair via nonhomologous end joining Source: Ensembl
  9. immunoglobulin V(D)J recombination Source: Ensembl
  10. isotype switching Source: Ensembl
  11. negative regulation of neuron apoptotic process Source: Ensembl
  12. neuron apoptotic process Source: Ensembl
  13. nucleotide-excision repair, DNA gap filling Source: Ensembl
  14. positive regulation of fibroblast proliferation Source: Ensembl
  15. positive regulation of neurogenesis Source: Ensembl
  16. pro-B cell differentiation Source: Ensembl
  17. response to gamma radiation Source: Ensembl
  18. response to X-ray Source: Ensembl
  19. single strand break repair Source: Ensembl
  20. somatic stem cell maintenance Source: Ensembl
  21. T cell differentiation in thymus Source: Ensembl
  22. T cell receptor V(D)J recombination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG4Imported
OrganismiMeleagris gallopavo (Common turkey)Imported
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaeMeleagridinaeMeleagris
ProteomesiUP000001645: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. condensed chromosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
  4. DNA ligase IV complex Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117695.
InParanoidiG1NR93.
KOiK10777.
OMAiHMCPSTK.
OrthoDBiEOG7BKCT2.
TreeFamiTF312980.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G1NR93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASAPASQLS PKRTVASHVP FADLCSTLER IQKCKSRPEK TKYFKDFLDS
60 70 80 90 100
WRKFHSALHQ KEKDVTDSFY PAMRLILPQL ERERMAYGIK ETMLAKLYIE
110 120 130 140 150
LLNLPKDGKD AVKLLNYRTP TGSRGDAGDF AMIAYFVLKP RSPKRGRLTV
160 170 180 190 200
EQVNELLDAI ANNNAAKNKG LVKKSLLQLI TQSTALEQKW LIRMIIKDLK
210 220 230 240 250
LGVSQQTIFS IFHPDAAELH NVTTDLEKVC RQLHDPSVSL SDVSIMLFSA
260 270 280 290 300
FKPMLAAIAD VQQIEKQMNN QVFYIETKLD GERMQMHKDG DVYKYFSRNG
310 320 330 340 350
FDYTQQFGAS PLDGSLTPFI HNVFKNDIQN CILDGEMMAY NPETQTFMQK
360 370 380 390 400
GNKFDIKRMV EDSDLQTCFC VFDVLMINDQ KLGHESLSKR YKILNNVFTP
410 420 430 440 450
VTGRIHVVHK KSARTRKEVI DALNEAIDNR EEGIMIKDPM STYKPDKRGE
460 470 480 490 500
GWLKIKPEYV NGLMDELDLL IVGGYWGKGS RGGMMSHFLC AIAETPAPNE
510 520 530 540 550
KPTAFHSICR VGSGYTMKEL YDLGLKLAKH WKPYNRKDPP CNILCGTEKP
560 570 580 590 600
EMYIEPCNSV IVQIKAAEIV DSDMYKTDCT LRFPRIEKIR EDKEWYECMT
610 620 630 640 650
LDMLEHLRSR AEGKLASKHL YIDEYDEPQE KKRRTVPKVK KVIGIAEQFK
660 670 680 690 700
APDLSNVNKV SSVFEDVEFC VMTGTGRYSK SELESKIAEC GGSVVQNPGP
710 720 730 740 750
DTYCVIVGAE NVRVKNIIAS NKYDVVKAEW LLQCFQSKML VPWQPAFMIH
760 770 780 790 800
MSPDTKEHFA REYDCYGDSY TADTDVAQLK EVFSRVKDNK RMPLDLIAEL
810 820 830 840 850
EERYSWNSCQ LCIFRGNTIY VDYYATINKP STKIHGTRLS VRALELRFYG
860 870 880 890 900
AKVVPLLEEG VSHVVIGEDH SRVKEVKALR RMFGKKFKIV SELWVTVSIK
910
EGAPKNENQF LI
Length:912
Mass (Da):104,286
Last modified:October 19, 2011 - v1
Checksum:i3C27F093A84A20D1
GO

Sequence databases

RefSeqiXP_003203267.1. XM_003203219.1.

Genome annotation databases

EnsembliENSMGAT00000017448; ENSMGAP00000016474; ENSMGAG00000015532.
GeneIDi100551140.
KEGGimgp:100551140.

Cross-referencesi

Sequence databases

RefSeqi XP_003203267.1. XM_003203219.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMGAT00000017448 ; ENSMGAP00000016474 ; ENSMGAG00000015532 .
GeneIDi 100551140.
KEGGi mgp:100551140.

Phylogenomic databases

GeneTreei ENSGT00750000117695.
InParanoidi G1NR93.
KOi K10777.
OMAi HMCPSTK.
OrthoDBi EOG7BKCT2.
TreeFami TF312980.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis."
    Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., Frederickson K.M.
    , Flicek P., Florea L., Folkerts O., Groenen M.A., Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.
    PLoS Biol. 8:E1000475-E1000475(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG1NR93_MELGA
AccessioniPrimary (citable) accession number: G1NR93
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3