Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G1NR93

- G1NR93_MELGA

UniProt

G1NR93 - G1NR93_MELGA

Protein

DNA ligase

Gene

LIG4

Organism
Meleagris gallopavo (Common turkey)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: Ensembl
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. central nervous system development Source: Ensembl
    3. chromosome organization Source: Ensembl
    4. DNA ligation involved in DNA recombination Source: Ensembl
    5. DNA ligation involved in DNA repair Source: Ensembl
    6. DNA replication Source: UniProtKB-KW
    7. double-strand break repair via nonhomologous end joining Source: Ensembl
    8. immunoglobulin V(D)J recombination Source: Ensembl
    9. in utero embryonic development Source: Ensembl
    10. isotype switching Source: Ensembl
    11. negative regulation of neuron apoptotic process Source: Ensembl
    12. neuron apoptotic process Source: Ensembl
    13. nucleotide-excision repair, DNA gap filling Source: Ensembl
    14. positive regulation of fibroblast proliferation Source: Ensembl
    15. positive regulation of neurogenesis Source: Ensembl
    16. pro-B cell differentiation Source: Ensembl
    17. response to gamma radiation Source: Ensembl
    18. response to X-ray Source: Ensembl
    19. single strand break repair Source: Ensembl
    20. somatic stem cell maintenance Source: Ensembl
    21. T cell differentiation in thymus Source: Ensembl
    22. T cell receptor V(D)J recombination Source: Ensembl

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:LIG4Imported
    OrganismiMeleagris gallopavo (Common turkey)Imported
    Taxonomic identifieri9103 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaeMeleagridinaeMeleagris
    ProteomesiUP000001645: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. condensed chromosome Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
    4. DNA ligase IV complex Source: Ensembl
    5. focal adhesion Source: Ensembl
    6. plasma membrane Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00750000117695.
    KOiK10777.
    OMAiHMCPSTK.
    OrthoDBiEOG7BKCT2.
    TreeFamiTF312980.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 2 hits.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF00533. BRCT. 1 hit.
    PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 2 hits.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 2 hits.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G1NR93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAPASQLS PKRTVASHVP FADLCSTLER IQKCKSRPEK TKYFKDFLDS    50
    WRKFHSALHQ KEKDVTDSFY PAMRLILPQL ERERMAYGIK ETMLAKLYIE 100
    LLNLPKDGKD AVKLLNYRTP TGSRGDAGDF AMIAYFVLKP RSPKRGRLTV 150
    EQVNELLDAI ANNNAAKNKG LVKKSLLQLI TQSTALEQKW LIRMIIKDLK 200
    LGVSQQTIFS IFHPDAAELH NVTTDLEKVC RQLHDPSVSL SDVSIMLFSA 250
    FKPMLAAIAD VQQIEKQMNN QVFYIETKLD GERMQMHKDG DVYKYFSRNG 300
    FDYTQQFGAS PLDGSLTPFI HNVFKNDIQN CILDGEMMAY NPETQTFMQK 350
    GNKFDIKRMV EDSDLQTCFC VFDVLMINDQ KLGHESLSKR YKILNNVFTP 400
    VTGRIHVVHK KSARTRKEVI DALNEAIDNR EEGIMIKDPM STYKPDKRGE 450
    GWLKIKPEYV NGLMDELDLL IVGGYWGKGS RGGMMSHFLC AIAETPAPNE 500
    KPTAFHSICR VGSGYTMKEL YDLGLKLAKH WKPYNRKDPP CNILCGTEKP 550
    EMYIEPCNSV IVQIKAAEIV DSDMYKTDCT LRFPRIEKIR EDKEWYECMT 600
    LDMLEHLRSR AEGKLASKHL YIDEYDEPQE KKRRTVPKVK KVIGIAEQFK 650
    APDLSNVNKV SSVFEDVEFC VMTGTGRYSK SELESKIAEC GGSVVQNPGP 700
    DTYCVIVGAE NVRVKNIIAS NKYDVVKAEW LLQCFQSKML VPWQPAFMIH 750
    MSPDTKEHFA REYDCYGDSY TADTDVAQLK EVFSRVKDNK RMPLDLIAEL 800
    EERYSWNSCQ LCIFRGNTIY VDYYATINKP STKIHGTRLS VRALELRFYG 850
    AKVVPLLEEG VSHVVIGEDH SRVKEVKALR RMFGKKFKIV SELWVTVSIK 900
    EGAPKNENQF LI 912
    Length:912
    Mass (Da):104,286
    Last modified:October 19, 2011 - v1
    Checksum:i3C27F093A84A20D1
    GO

    Sequence databases

    RefSeqiXP_003203267.1. XM_003203219.1.

    Genome annotation databases

    EnsembliENSMGAT00000017448; ENSMGAP00000016474; ENSMGAG00000015532.
    GeneIDi100551140.
    KEGGimgp:100551140.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_003203267.1. XM_003203219.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMGAT00000017448 ; ENSMGAP00000016474 ; ENSMGAG00000015532 .
    GeneIDi 100551140.
    KEGGi mgp:100551140.

    Phylogenomic databases

    GeneTreei ENSGT00750000117695.
    KOi K10777.
    OMAi HMCPSTK.
    OrthoDBi EOG7BKCT2.
    TreeFami TF312980.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 2 hits.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF00533. BRCT. 1 hit.
    PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 2 hits.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 2 hits.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis."
      Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., Frederickson K.M.
      , Flicek P., Florea L., Folkerts O., Groenen M.A., Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.
      PLoS Biol. 8:E1000475-E1000475(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiG1NR93_MELGA
    AccessioniPrimary (citable) accession number: G1NR93
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3