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G1NR93

- G1NR93_MELGA

UniProt

G1NR93 - G1NR93_MELGA

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Protein
DNA ligase
Gene
LIG4
Organism
Meleagris gallopavo (Common turkey)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA recombination Source: Ensembl
  2. DNA ligation involved in DNA repair Source: Ensembl
  3. DNA replication Source: UniProtKB-KW
  4. T cell differentiation in thymus Source: Ensembl
  5. T cell receptor V(D)J recombination Source: Ensembl
  6. cell proliferation Source: Ensembl
  7. central nervous system development Source: Ensembl
  8. chromosome organization Source: Ensembl
  9. double-strand break repair via nonhomologous end joining Source: Ensembl
  10. immunoglobulin V(D)J recombination Source: Ensembl
  11. in utero embryonic development Source: Ensembl
  12. isotype switching Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. neuron apoptotic process Source: Ensembl
  15. nucleotide-excision repair, DNA gap filling Source: Ensembl
  16. positive regulation of fibroblast proliferation Source: Ensembl
  17. positive regulation of neurogenesis Source: Ensembl
  18. pro-B cell differentiation Source: Ensembl
  19. response to X-ray Source: Ensembl
  20. response to gamma radiation Source: Ensembl
  21. single strand break repair Source: Ensembl
  22. somatic stem cell maintenance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG4Imported
OrganismiMeleagris gallopavo (Common turkey)Imported
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaeMeleagridinaeMeleagris
ProteomesiUP000001645: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. DNA ligase IV complex Source: Ensembl
  2. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
  3. condensed chromosome Source: Ensembl
  4. cytoplasm Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00750000117695.
KOiK10777.
OMAiHMCPSTK.
OrthoDBiEOG7BKCT2.
TreeFamiTF312980.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G1NR93-1 [UniParc]FASTAAdd to Basket

« Hide

MASAPASQLS PKRTVASHVP FADLCSTLER IQKCKSRPEK TKYFKDFLDS    50
WRKFHSALHQ KEKDVTDSFY PAMRLILPQL ERERMAYGIK ETMLAKLYIE 100
LLNLPKDGKD AVKLLNYRTP TGSRGDAGDF AMIAYFVLKP RSPKRGRLTV 150
EQVNELLDAI ANNNAAKNKG LVKKSLLQLI TQSTALEQKW LIRMIIKDLK 200
LGVSQQTIFS IFHPDAAELH NVTTDLEKVC RQLHDPSVSL SDVSIMLFSA 250
FKPMLAAIAD VQQIEKQMNN QVFYIETKLD GERMQMHKDG DVYKYFSRNG 300
FDYTQQFGAS PLDGSLTPFI HNVFKNDIQN CILDGEMMAY NPETQTFMQK 350
GNKFDIKRMV EDSDLQTCFC VFDVLMINDQ KLGHESLSKR YKILNNVFTP 400
VTGRIHVVHK KSARTRKEVI DALNEAIDNR EEGIMIKDPM STYKPDKRGE 450
GWLKIKPEYV NGLMDELDLL IVGGYWGKGS RGGMMSHFLC AIAETPAPNE 500
KPTAFHSICR VGSGYTMKEL YDLGLKLAKH WKPYNRKDPP CNILCGTEKP 550
EMYIEPCNSV IVQIKAAEIV DSDMYKTDCT LRFPRIEKIR EDKEWYECMT 600
LDMLEHLRSR AEGKLASKHL YIDEYDEPQE KKRRTVPKVK KVIGIAEQFK 650
APDLSNVNKV SSVFEDVEFC VMTGTGRYSK SELESKIAEC GGSVVQNPGP 700
DTYCVIVGAE NVRVKNIIAS NKYDVVKAEW LLQCFQSKML VPWQPAFMIH 750
MSPDTKEHFA REYDCYGDSY TADTDVAQLK EVFSRVKDNK RMPLDLIAEL 800
EERYSWNSCQ LCIFRGNTIY VDYYATINKP STKIHGTRLS VRALELRFYG 850
AKVVPLLEEG VSHVVIGEDH SRVKEVKALR RMFGKKFKIV SELWVTVSIK 900
EGAPKNENQF LI 912
Length:912
Mass (Da):104,286
Last modified:October 19, 2011 - v1
Checksum:i3C27F093A84A20D1
GO

Sequence databases

RefSeqiXP_003203267.1. XM_003203219.1.

Genome annotation databases

EnsembliENSMGAT00000017448; ENSMGAP00000016474; ENSMGAG00000015532.
GeneIDi100551140.
KEGGimgp:100551140.

Cross-referencesi

Sequence databases

RefSeqi XP_003203267.1. XM_003203219.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMGAT00000017448 ; ENSMGAP00000016474 ; ENSMGAG00000015532 .
GeneIDi 100551140.
KEGGi mgp:100551140.

Phylogenomic databases

GeneTreei ENSGT00750000117695.
KOi K10777.
OMAi HMCPSTK.
OrthoDBi EOG7BKCT2.
TreeFami TF312980.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis."
    Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., Frederickson K.M.
    , Flicek P., Florea L., Folkerts O., Groenen M.A., Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.
    PLoS Biol. 8:E1000475-E1000475(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG1NR93_MELGA
AccessioniPrimary (citable) accession number: G1NR93
Entry historyi
Integrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: September 3, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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