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Protein

Annexin

Gene

ANXA1

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
OrganismiAiluropoda melanoleuca (Giant panda)Imported
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
Proteomesi
  • UP000008912 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000016422.

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiG1MAP8.
KOiK17091.
OMAiGTRHKTL.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
IPR002388. ANX1.
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 3 hits.

Sequencei

Sequence statusi: Complete.

G1MAP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVSEFLKQ AWFIENEEQE YIKTVKGSKG GPGSAVSPYP SFNPSSDVTA
60 70 80 90 100
LHNAITVKGV DEATIIDILT KRNNAQRQQI KAAYLQEKGK PLDEALKKAL
110 120 130 140 150
SGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLDEI LVSRTNKEIR
160 170 180 190 200
EINRVYREEL KRDLAKDITS DTSGDYRNAL LSLAKGDRSE DFGLNDDLAD
210 220 230 240 250
SDARALYEAG ERRKGTDVNV FITILTTRAY PHLRQVFQKY SKYSKHDMKK
260 270 280 290 300
VLDLEMKGDI EKCLTAIVKC ATSKPMFFAE KLHQAMKGSG TRHKTLIRIM
310 320 330 340
VSRSEIDMND IKACYQKLYG VSLCQAILDE TKGDYEKILV ALCGD
Length:345
Mass (Da):38,641
Last modified:October 19, 2011 - v1
Checksum:i45833D88353DC981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01076673 Genomic DNA. No translation available.
ACTA01084673 Genomic DNA. No translation available.
RefSeqiXP_011215457.1. XM_011217155.2.

Genome annotation databases

EnsembliENSAMET00000017101; ENSAMEP00000016422; ENSAMEG00000015540.
GeneIDi100469292.
KEGGiaml:100469292.

Similar proteinsi

Entry informationi

Entry nameiG1MAP8_AILME
AccessioniPrimary (citable) accession number: G1MAP8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 25, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported